Effects of creatine monohydrate supplementation on muscle mass and physical performance in trained young adults: a systematic review
DOI:
https://doi.org/10.47197/retos.v62.110771Keywords:
Physical exercise, Muscle power, Muscle hypertrophy, Muscle atrophyAbstract
The aim of this review was to analyze the effects of creatine monohydrate (CrM) supplementation on muscle mass (MM) and physical performance in trained young adults, using the available evidence. The systematic review was conducted, based on the PRISMA 2020 protocol, using the PubMed and Google Scholar databases. Clinical trials published during 2010-2023 in Spanish, English or Portuguese were included. 87 studies were found and 7 approved of the inclusion criteria. Significant effects of CrM intake on MM, muscle strength (FM) and muscle power in trained young adults were reported, in the short and medium term. We conclude that CrM supplementation is effective in improving muscle composition and physical performance in trained young adults. In addition, the moment of intake is important, with better results when ingested after training. Also, the suggested amounts correspond to 0.1g x kg x day or 5g daily, with significant effects with both doses.
References
Alvarez-Rayón, G., García-Rodríguez, J., Martínez-Quintero, F., León, C. E. P. de, & Ortega-Luyando, M. (2022). Uso de sustancias ergogénicas entre hombres mexicanos practicantes de musculación: Un estudio transversal (Use of er-gogenic substances among in Mexican men that engage in weight training: a cross-sectional study). Retos, 46, 801-808. https://doi.org/10.47197/retos.v46.89712
Antonio, J., & Ciccone, V. (2013). The effects of pre versus post workout supplementation of creatine monohydrate on body composition and strength. Journal of the International Society of Sports Nutrition, 10(1), 36. https://doi.org/10.1186/1550-2783-10-36
Anugrah, S. M., Kusnanik, N. W., Wahjuni, E. S., Zubaida, I., Triprayogo, R., Dhani, D. P., Resmana, D., Ayubi, N., Sari, E., & Mulyawan, R. (2024). Investigating the Impact of Varied Dosages of Royal Jelly Consumption on Creatine Kinase and Interleukin-6 Levels Post High-Intensity Resistance Training. Retos, 55, 428-435. https://doi.org/10.47197/retos.v55.103569
Araujo, S., Ibiapina, J. S., & de Carvalho, L. M. F. (2022). Evidência sobre o uso de creatina em homens ou mulheres praticantes de atividade física. Research, Society and Development, 11(17), e156111739063-e156111739063. https://doi.org/10.33448/rsd-v11i17.39063
Ataídes, K. C., Neto, M., & dos Santos, J. (2022). Benefícios e malefícios da suplementação com creatina. Scientific Electronic Archives, 15(10). DOI: https://doi.org/10.36560/151020221611
Avelino, J. M. G. ., & Ferreira, J. C. de S. (2022). Benefits of creatine in performance and muscle strength develop-ment. Research, Society and Development, 11(8), e0711830491. https://doi.org/10.33448/rsd-v11i8.30491
Backx, E. M. P., Hangelbroek, R., Snijders, T., Verscheijden, M. L., Verdijk, L. B., de Groot, L. C. P. G. M., & van Loon, L. J. C. (2017). Creatine Loading Does Not Preserve Muscle Mass or Strength During Leg Immobilization in Healthy, Young Males: A Randomized Controlled Trial. Sports Medicine, 47(8), 1661–1671. https://doi.org/10.1007/s40279-016-0670-2
Bonilla, D. A., Kreider, R. B., Petro, J. L., Romance, R., García-Sillero, M., Benítez-Porres, J., & Vargas-Molina, S. (2021). Creatine enhances the effects of cluster-set resistance training on lower-limb body composition and strength in resistance-trained men: a pilot study. Nutrients, 13(7), 2303. https://doi.org/10.3390/nu13072303
Burgos, M. P. (2017). Efectos ergogénicos en la suplementación con monohidrato de creatina en entrenamiento funcio-nal de alta intensidad. Rev of Sports Training, 31(3), 12-20. Disponible en: https://g-se.com/efectos-ergogenicos-en-la-suplementacion-con-monohidrato-de-creatina-en-entrenamiento-funcional-de-alta-intensidad-2335-sa-B5a050c3d35098
Burke, R., Piñero, A., Coleman, M., Mohan, A., Sapuppo, M., Augustin, F., ... & Schoenfeld, B. J. (2023). The effects of creatine supplementation combined with resistance training on regional measures of muscle hypertrophy: a sys-tematic review with meta-analysis. Nutrients, 15(9), 2116. https://doi.org/10.3390/nu15092116
Chigachiaraguti Santi, M., Martínez Galán, B. S., Morhy Terrazas, S. I., Giolo De Carvalho, F., Sambrano Vieira, T., Cerizza Silveira, G., … Cristini de Freitas, E. (2020). Effect of creatine supplementation on muscle damage markers and physical performance in volleyball athletes (Efecto de la suplementación de creatina sobre marcadores de daño muscular y desempeño físico en atletas de voleibol). Cultura, Ciencia Y Deporte, 15(45), 377–385. DOI: https://doi.org/10.12800/ccd.v15i45.1515
De Faria, D. P. B. (2018). Suplementação de creatina no ganho de força e hipertrofia muscular em praticantes de treinamento de força: uma breve revisão narrativa. Revista Eletrônica Acervo Saúde/Electronic Journal Collection Health, 16(3), 2091. Disponible en: https://www.scielo.br/j/rbme/a/mmQrVRgg9cqRxGwVC54kR6D
Delpino, F. M., Figueiredo, L. M., Forbes, S. C., Candow, D. G., & Santos, H. O. (2022). Influence of age, sex, and type of exercise on the efficacy of creatine supplementation on lean body mass: A systematic review and meta-analysis of randomized clinical trials. Nutrition, 103, 111791. https://doi.org/10.1016/j.nut.2022.111791
Fernández-Landa, J., Calleja-González, J., León-Guereño, P., Caballero-García, A., Córdova, A., & Mielgo-Ayuso, J. (2019). Effect of the combination of creatine monohydrate plus HMB supplementation on sports performance, body composition, markers of muscle damage and hormone status: A systematic review. Nutrients, 11(10), 2528. https://doi.org/10.3390/nu11102528
Fernández-Landa, J., Fernández-Lázaro, D., Calleja-González, J., Caballero-García, A., Cordova Martinez, A., León-Guereño, P., & Mielgo-Ayuso, J. (2020). Effect of ten weeks of creatine monohydrate plus HMB supplementation on athletic performance tests in elite male endurance athletes. Nutrients, 12(1), 193. https://doi.org/10.3390/nu12010193
Forbes, S. C., Cordingley, D. M., Cornish, S. M., Gualano, B., Roschel, H., Ostojic, S. M., ... & Candow, D. G. (2022). Effects of creatine supplementation on brain function and health. Nutrients, 14(5), 921. https://doi.org/10.3390/nu14050921
Gómez-Álvarez, N., Jofré-Hermosilla, N., Matus-Castillo, C., & Pavez-Adasme, G. (2019). Efectos del entrenamiento de fuerza muscular en mujeres post- menopáusicas con síndrome metabólico. Revisión sistemática. (Effects of muscle strength training in postmenopausal women with metabolic syndrome. Systematic review). Cultura, Ciencia Y De-porte, 14(42), 213–224. https://doi.org/10.12800/ccd.v14i42.1334
Guevara, V. M., Montalva-Valenzuela, F., Andrades-Ramírez, O., Vargas, J. J. N., Flores, I., & Castillo-Paredes, A. (2024). Futbol y creatina, una revisión sistemática (Soccer and creatine, a systematic review). Retos, 51, 763-770. https://doi.org/10.47197/retos.v51.97367
Hall, M., Manetta, E., & Tupper, K. (2021). Creatine supplementation: an update. Current Sports Medicine Reports, 20(7), 338-344. https://doi.org/10.1249/JSR.0000000000000863
Higgins, J. P., & Green, S. (2011). Manual Cochrane de revisiones sistemáticas de intervenciones. The Cochrane Colla-boration, 1-639. Disponible en: https://es.cochrane.org/sites/es.cochrane.org/files/uploads/Manual_Cochrane_510_reduit.pdf
Jurado-Castro, J. M., Navarrete-Pérez, A., Ranchal-Sánchez, A., & Ordóñez, F. M. (2021). Optimum timing in creatine supplementation for improved sporting performance. Archivos de Medicina del Deporte, 38(1), 48-53. https://doi.org/10.18176/archmeddeporte.00026
Kreider, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., ... & Lopez, H. L. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14(1), 18. https://doi.org/10.1186/s12970-017-0173-z
Kreider, R. B., Jäger, R., & Purpura, M. (2022). Bioavailability, efficacy, safety, and regulatory status of creatine and related compounds: A critical review. Nutrients, 14(5), 1035. https://doi.org/10.3390/nu14051035
Mielgo-Ayuso, J., Calleja-Gonzalez, J., Marqués-Jiménez, D., Caballero-García, A., Córdova, A., & Fernández-Lázaro, D. (2019). Effects of creatine supplementation on athletic performance in soccer players: a systematic review and meta-analysis. Nutrients, 11(4), 757. https://doi.org/10.3390/nu11040757
Mills, S., Candow, D. G., Forbes, S. C., Neary, J. P., Ormsbee, M. J., & Antonio, J. (2020). Effects of creatine supple-mentation during resistance training sessions in physically active young adults. Nutrients, 12(6), 1880. https://doi.org/10.3390/nu12061880
Miranda Oliveira, L., De Oliveira Azevedo, M., & De Souza Cardoso, C. K. (2017). Efeitos da suplementação de creatina sobre a composição corporal de praticantes de exercí¬cios fí-sicos: uma revisão de literatura. RBNE - Revista Brasileira De Nutrição Esportiva, 11(61), 10-15. Disponible en: https://www.rbne.com.br/index.php/rbne/article/view/618
Moreira, O. C., de Oliveira, C. E., Candia-Luján, R., Romero-Pérez, E. M., & de Paz Fernandez, J. A. (2015). Methods of evaluation of muscle mass: a systematic review of randomized controlled trials. Nutricion Hospitalaria, 32(3), 977–985. https://doi.org/10.3305/nh.2015.32.3.9322
Naclerio, F. (2023). Suplementación con preparados de ingredientes múltiples en personas activas. Revista Iberoameri-cana de Ciencias de la Actividad Física y el Deporte, 12(3), 42–51. https://doi.org/10.24310/riccafd.12.3.2023.17761
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., ... & Alonso-Fernández, S. (2021). Declaración PRISMA 2020: una guía actualizada para la publicación de revisiones sistemáticas. Revista Espa-ñola de Cardiología, 74(9), 790-799. https://doi.org/10.1016/j.recesp.2021.06.016
Pierard, S. M. C., Baquero, J. F. Z., Jiménez, S. O. I., Dos Santos, S. P. L., & Proaño, A. C. E. (2020). Composición corporal en relación con la ingesta calórica y de macronutrientes. Polo del Conocimiento: Revista Científico-Profesional, 5(10), 937-947. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=7659411
Rebolledo-Cobos, R., Correa, C. S., Juliao-Castillo, J., Gallardo, R. P., & Landazabal, O. S. (2017). Implicaciones fun-cionales del entrenamiento de la fuerza en el adulto mayor: una revisión de literatura. Arch. Méd. Deporte, 34, 31-39. Disponible en: https://archivosdemedicinadeldeporte.com/articulos/upload/rev01_rebolledo-1.pdf
Sestili, P., Martinelli, C., Colombo, E., Barbieri, E., Potenza, L., Sartini, S., & Fimognari, C. (2011). Creatine as an antioxidant. Amino Acids, 40, 1385-1396. DOI: https://doi.org/10.1007/s00726-011-0875-5
Wyss, M., & Kaddurah-Daouk, R. (2000). Creatine and creatinine metabolism. Physiological Reviews, 80(3), 1107-1213. https://doi.org/10.1152/physrev.2000.80.3.1107
Zanelli, J.C., Cordeiro, B.A., Beserra, B.T., & Trindade, E.B. (2015). Creatine and resistance training: effect on hydra-tion and lean body mass. Revista Brasileira De Medicina Do Esporte, 21, 27-31. https://doi.org/10.1590/1517-86922015210101932
Zuniga, J. M., Housh, T. J., Camic, C. L., Hendrix, C. R., Mielke, M., Johnson, G. O., ... & Schmidt, R. J. (2012). The effects of creatine monohydrate loading on anaerobic performance and one-repetition maximum strength. The Journal of Strength & Conditioning Research, 26(6), 1651-1656. https://doi.org/10.1519/JSC.0b013e318234eba1
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Bastián Parada-Flores , Luis Valenzuela Contreras , Scarlet Aldana-Lara , Valentina Salgado-Abasolo, Cristian Martínez Salazar, Jorge Flández Valderrama , Carol Flores-Rivera, Pablo Felipe Luna-Villouta, Rodrigo Vargas Vitoria
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and ensure the magazine the right to be the first publication of the work as licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of authorship of the work and the initial publication in this magazine.
- Authors can establish separate additional agreements for non-exclusive distribution of the version of the work published in the journal (eg, to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Is allowed and authors are encouraged to disseminate their work electronically (eg, in institutional repositories or on their own website) prior to and during the submission process, as it can lead to productive exchanges, as well as to a subpoena more Early and more of published work (See The Effect of Open Access) (in English).
This journal provides immediate open access to its content (BOAI, http://legacy.earlham.edu/~peters/fos/boaifaq.htm#openaccess) on the principle that making research freely available to the public supports a greater global exchange of knowledge. The authors may download the papers from the journal website, or will be provided with the PDF version of the article via e-mail.