Physical exercise post-treatment in breast cancer: a longitudinal study

Authors

  • Nur Azis Rohmansyah Universitas Negeri Yogyakarta
  • Faza Annasai Universitas Negeri Yogyakarta
  • Abiyyu Amajida Universitas Negeri Yogyakarta
  • Sunaryo Sunaryo Universitas Negeri Yogyakarta
  • Rian Ka Praja Universitas Palangka Raya
  • Yanyong Phanpheng Loei Rajabhat University
  • Neranoch Bumrung Khon Kaen University
  • Ashira Hiruntrakul Khon Kaen University

DOI:

https://doi.org/10.47197/retos.v60.109318

Keywords:

breast cancer; physical exercise; anxiety; post-traumatic stress disorder; quality of life

Abstract

The prevalence of breast cancer has been progressively rising as a result of advancements in anti-cancer therapies, however, these patients also experience a variety of long-term adverse effects from their illness and treatments. The current study sought to determine how an exercise training intervention influenced physical and mental health indices in breast cancer patients. A total of 30 female breast cancer patients (aged 42.81 ± 3.31 years, body mass index (BMI) 26.87 ± 0.59 kg/m2, and waist circumference 97.61 ± 1.94 cm) engaged in 12 weekly exercise regimens twice weekly that comprised aerobic, resistance, and flexibility activities. The exercise intervention improved participants' cardiorespiratory fitness, BMI, waist circumference, and muscle function, including sitting to standing, sit-ups, and push-ups. It also showed positive results for post-traumatic stress disorder (PTSD) symptoms, self-reported fatigue, quality of life, and physical, cognitive, and emotional functioning (p < 0.001). In conclusion, our results imply that the advantages of an exercise training program may help breast cancer patients lessen the negative impacts of treatment-related factors on physical performance, overall quality of life, and mental health.

Keywords: breast cancer; physical exercise; anxiety; post-traumatic stress disorder; quality of life

References

Kementerian Kesehatan Republik Indonesia. Laporan Nasional Riskesdas 2018. Published online 2018.

Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality World-wide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-249. doi:10.3322/caac.21660

Giaquinto AN, Sung H, Miller KD, et al. Breast Cancer Statistics, 2022. CA Cancer J Clin. 2022;72(6):524-541. doi:10.3322/caac.21754

Papaoiconomou E, Lymperi M, Petraki C, et al. Kiss-1/GPR54 protein expression in breast cancer. Anticancer Res. 2014;34(3):1401-1407.

Islami F, Goding Sauer A, Miller KD, et al. Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States. CA Cancer J Clin. 2018;68(1):31-54. doi:10.3322/caac.21440

Yfantis A, Sarafis P, Moisoglou I, et al. How breast cancer treatments affect the quality of life of women with non-metastatic breast cancer one year after surgical treatment: a cross-sectional study in Greece. BMC Surg. 2020;20(1):210. doi:10.1186/s12893-020-00871-z

Lovelace DL, McDaniel LR, Golden D. Long-Term Effects of Breast Cancer Surgery, Treatment, and Survivor Care. J Mid-wifery Womens Health. 2019;64(6):713-724. doi:10.1111/jmwh.13012

Schmidt ME, Scherer S, Wiskemann J, Steindorf K. Return to work after breast cancer: The role of treatment-related side effects and potential impact on quality of life. Eur J Cancer Care (Engl). 2019;28(4):e13051. doi:10.1111/ecc.13051

Boscher C, Joly F, Clarisse B, et al. Perceived Cognitive Impairment in Breast Cancer Survivors and Its Relationships with Psychological Factors. Cancers (Basel). 2020;12(10):3000. doi:10.3390/cancers12103000

Yi JC, Syrjala KL. Anxiety and Depression in Cancer Survivors. Med Clin North Am. 2017;101(6):1099-1113. doi:10.1016/j.mcna.2017.06.005

Natalucci V, Marini CF, Flori M, et al. Effects of a Home-Based Lifestyle Intervention Program on Cardiometabolic Health in Breast Cancer Survivors during the COVID-19 Lockdown. J Clin Med. 2021;10(12):2678. doi:10.3390/jcm10122678

Kelly DL, Yang GS, Starkweather AR, Siangphoe U, Alexander-Delpech P, Lyon DE. Relationships Among Fatigue, Anxiety, Depression, and Pain and Health-Promoting Lifestyle Behaviors in Women With Early-Stage Breast Cancer. Cancer Nurs. 2020;43(2):134-146. doi:10.1097/NCC.0000000000000676

Papadopetraki A, Maridaki M, Zagouri F, Dimopoulos MA, Koutsilieris M, Philippou A. Physical Exercise Restrains Cancer Progression through Muscle-Derived Factors. Cancers (Basel). 2022;14(8):1892. doi:10.3390/cancers14081892

Adraskela K, Veisaki E, Koutsilieris M, Philippou A. Physical Exercise Positively Influences Breast Cancer Evolution. Clin Breast Cancer. 2017;17(6):408-417. doi:10.1016/j.clbc.2017.05.003

Ntanasis-Stathopoulos J, Tzanninis JG, Philippou A, Koutsilieris M. Epigenetic regulation on gene expression induced by physical exercise. J Musculoskelet Neuronal Interact. 2013;13(2):133-146.

D’Ascenzi F, Anselmi F, Fiorentini C, Mannucci R, Bonifazi M, Mondillo S. The benefits of exercise in cancer patients and the criteria for exercise prescription in cardio-oncology. Eur J Prev Cardiol. 2021;28(7):725-735. doi:10.1177/2047487319874900

Köse E, Aydin M, Köse O, Aksu MG, Sekban G. The efficiency of a mixed exercise program on quality of life and fatigue levels in patients with breast cancer. Rev Assoc Med Bras (1992). 2021;67(9):1279-1285. doi:10.1590/1806-9282.20210539

Salchow JL, Strunk MA, Niels T, Steck J, Minto CA, Baumann FT. A Randomized Controlled Pilot Trial About the Influence of Kyusho Jitsu Exercise on Self-efficacy, Fear, Depression, and Distress of Breast Cancer Patients within Follow-up Care. Integr Cancer Ther. 2021;20:15347354211037955. doi:10.1177/15347354211037955

Maridaki M, Papadopetraki A, Karagianni H, Koutsilieris M, Philippou A. The Assessment and Relationship Between Quality of Life and Physical Activity Levels in Greek Breast Cancer Female Patients under Chemotherapy. Sports (Basel). 2020;8(3):32. doi:10.3390/sports8030032

Anderson E, Shivakumar G. Effects of Exercise and Physical Activity on Anxiety. Front Psychiatry. 2013;4:27. doi:10.3389/fpsyt.2013.00027

Smith-Turchyn J, Allen L, Dart J, et al. Characterizing the Exercise Behaviour, Preferences, Barriers, and Facilitators of Cancer Survivors in a Rural Canadian Community: A Cross-Sectional Survey. Curr Oncol. 2021;28(4):3172-3187. doi:10.3390/curroncol28040276

Galiano-Castillo N, Cantarero-Villanueva I, Fernández-Lao C, et al. Telehealth system: A randomized controlled trial evalu-ating the impact of an internet-based exercise intervention on quality of life, pain, muscle strength, and fatigue in breast cancer survivors. Cancer. 2016;122(20):3166-3174. doi:10.1002/cncr.30172

Sagarra-Romero L, Butragueño J, Gomez-Bruton A, Lozano-Berges G, Vicente-Rodríguez G, Morales JS. Effects of an online home-based exercise intervention on breast cancer survivors during COVID-19 lockdown: a feasibility study. Support Care Cancer. 2022;30(7):6287-6297. doi:10.1007/s00520-022-07069-4

Grazioli E, Cerulli C, Dimauro I, Moretti E, Murri A, Parisi A. New Strategy of Home-Based Exercise during Pandemic COVID-19 in Breast Cancer Patients: A Case Study. Sustainability. 2020;12(17):6940. doi:10.3390/su12176940

Gonzalo-Encabo P, Wilson RL, Kang DW, Normann AJ, Dieli-Conwright CM. Exercise oncology during and beyond the COVID-19 pandemic: Are virtually supervised exercise interventions a sustainable alternative? Crit Rev Oncol Hematol. 2022;174:103699. doi:10.1016/j.critrevonc.2022.103699

Spector D, Deal AM, Amos KD, Yang H, Battaglini CL. A pilot study of a home-based motivational exercise program for African American breast cancer survivors: clinical and quality-of-life outcomes. Integr Cancer Ther. 2014;13(2):121-132. doi:10.1177/1534735413503546

Navalta JW, Stone WJ, Lyons TS. Ethical Issues Relating to Scientific Discovery in Exercise Science. Int J Exerc Sci. 2019;12(1):1-8.

Shachar SS, Williams GR. The obesity paradox in cancer – moving beyond BMI. Cancer Epidemiol Biomarkers Prev. 2017;26(1):13-16. doi:10.1158/1055-9965.EPI-16-0439

Dieli-Conwright CM, Sami N, Norris MK, et al. Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors. Sci Rep. 2021;11(1):16916. doi:10.1038/s41598-021-96419-z

But-Hadzic J, Dervisevic M, Karpljuk D, et al. Six-Minute Walk Distance in Breast Cancer Survivors-A Systematic Review with Meta-Analysis. Int J Environ Res Public Health. 2021;18(5). doi:10.3390/ijerph18052591

Stefani L, Galanti G, Klika R. Clinical Implementation of Exercise Guidelines for Cancer Patients: Adaptation of ACSM’s Guidelines to the Italian Model. Journal of Functional Morphology and Kinesiology. 2017;2(1):4. doi:10.3390/jfmk2010004

Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31. doi:10.1093/ageing/afy169

Fayers P, Bottomley A, EORTC Quality of Life Group, Quality of Life Unit. Quality of life research within the EORTC-the EORTC QLQ-C30. European Organisation for Research and Treatment of Cancer. Eur J Cancer. 2002;38 Suppl 4:S125-133. doi:10.1016/s0959-8049(01)00448-8

Shi L, Wang L, Jia X, et al. Prevalence and correlates of symptoms of post-traumatic stress disorder among Chinese healthcare workers exposed to physical violence: a cross-sectional study. BMJ Open. 2017;7(7):e016810. doi:10.1136/bmjopen-2017-016810

Hoque MdN, Hannan A, Imran S, Alam MA, Matubber B, Saha SM. Anxiety and Its Determinants among Undergraduate Students during E-learning in Bangladesh Amid Covid-19. J Affect Disord Rep. 2021;6:100241. doi:10.1016/j.jadr.2021.100241

JOHNSON SL, STONE WJ, BUNN JA, LYONS TS, NAVALTA JW. New Author Guidelines in Statistical Reporting: Em-bracing an Era Beyond p < .05. Int J Exerc Sci. 2020;13(1):1-5.

Reeves MM, Terranova CO, Winkler EAH, et al. Effect of a Remotely Delivered Weight Loss Intervention in Early-Stage Breast Cancer: Randomized Controlled Trial. Nutrients. 2021;13(11):4091. doi:10.3390/nu13114091

Dieli-Conwright CM, Courneya KS, Demark-Wahnefried W, et al. Effects of Aerobic and Resistance Exercise on Metabolic Syndrome, Sarcopenic Obesity, and Circulating Biomarkers in Overweight or Obese Survivors of Breast Cancer: A Ran-domized Controlled Trial. J Clin Oncol. 2018;36(9):875-883. doi:10.1200/JCO.2017.75.7526

Ochi E, Tsuji K, Narisawa T, et al. Cardiorespiratory fitness in breast cancer survivors: a randomised controlled trial of home-based smartphone supported high intensity interval training. BMJ Support Palliat Care. 2022;12(1):33-37. doi:10.1136/bmjspcare-2021-003141

Dieli-Conwright CM, Courneya KS, Demark-Wahnefried W, et al. Aerobic and resistance exercise improves physical fit-ness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial. Breast Cancer Res. 2018;20(1):124. doi:10.1186/s13058-018-1051-6

Lee MK, Lee DH, Park S, Kim SI, Jeon JY. Relationship between resting heart rate and metabolic risk factors in breast can-cer patients. Clin Chim Acta. 2018;486:104-109. doi:10.1016/j.cca.2018.07.032

Lee DH, Park S, Lim SM, et al. Resting heart rate as a prognostic factor for mortality in patients with breast cancer. Breast Cancer Res Treat. 2016;159(2):375-384. doi:10.1007/s10549-016-3938-1

Gell NM, Dittus K, Caefer J, Martin A, Bae M, Patel KV. Remotely delivered exercise to older rural cancer survivors: a randomized controlled pilot trial. J Cancer Surviv. 2024;18(2):596-605. doi:10.1007/s11764-022-01292-y

Gorzelitz JS, Stoller S, Costanzo E, et al. Improvements in strength and agility measures of functional fitness following a tele-health-delivered home-based exercise intervention in endometrial cancer survivors. Support Care Cancer. 2022;30(1):447-455. doi:10.1007/s00520-021-06415-2

Kim JY, Lee MK, Lee DH, et al. Effects of a 12-week home-based exercise program on quality of life, psychological health, and the level of physical activity in colorectal cancer survivors: a randomized controlled trial. Support Care Cancer. 2019;27(8):2933-2940. doi:10.1007/s00520-018-4588-0

Li J, Liu Y, Jiang J, Peng X, Hu X. Effect of telehealth interventions on quality of life in cancer survivors: A systematic re-view and meta-analysis of randomized controlled trials. Int J Nurs Stud. 2021;122:103970. doi:10.1016/j.ijnurstu.2021.103970

De Luca V, Minganti C, Borrione P, et al. Effects of concurrent aerobic and strength training on breast cancer survivors: a pilot study. Public Health. 2016;136:126-132. doi:10.1016/j.puhe.2016.03.028

Paulo TRS, Rossi FE, Viezel J, et al. The impact of an exercise program on quality of life in older breast cancer survivors undergoing aromatase inhibitor therapy: a randomized controlled trial. Health Qual Life Outcomes. 2019;17(1):17. doi:10.1186/s12955-019-1090-4

Schmitz KH, Troxel AB, Dean LT, et al. Effect of Home-Based Exercise and Weight Loss Programs on Breast Cancer-Related Lymphedema Outcomes Among Overweight Breast Cancer Survivors: The WISER Survivor Randomized Clini-cal Trial. JAMA Oncol. 2019;5(11):1605-1613. doi:10.1001/jamaoncol.2019.2109

Downloads

Published

2024-11-01

How to Cite

Rohmansyah, N. A., Annasai, F., Amajida, A., Sunaryo, S., Ka Praja, R. ., Phanpheng, Y., Bumrung, N., & Hiruntrakul, A. (2024). Physical exercise post-treatment in breast cancer: a longitudinal study. Retos, 60, 774–781. https://doi.org/10.47197/retos.v60.109318

Issue

Section

Original Research Article

Most read articles by the same author(s)

1 2 > >>