Serum irisin is positively associated with adiposity markers in obese women after single-session exercise-induced

Authors

  • Bayu Agung Pramono Universitas Negeri Surabaya
  • Adi Pranoto Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga https://orcid.org/0000-0003-4080-9245
  • I Dewa Made Aryananda Wijaya Kusuma Department of Sports Coaching Education, Faculty of Sports and Health Science, Universitas Negeri Surabaya https://orcid.org/0000-0002-4939-7294
  • Ghana Firsta Yosika Study Program of Sports Coaching Education, Faculty of Teacher Training and Education, Universitas Tanjungpura
  • Yanyong Phanpheng Loei Rajabhat University https://orcid.org/0000-0002-9290-2479

DOI:

https://doi.org/10.47197/retos.v58.106845

Keywords:

Serum irisin, adiposity markers, female, obesity

Abstract

The link between serum irisin levels and body fat markers has long been questioned in adult populations. However, there is scant research specifically addressing this link in obese female individuals. This study will thoroughly evaluate the relationship between serum irisin levels and adiposity indices in an obese female population. The study involved a group of 40 women, aged between 20 and 24 years, who were experiencing obesity. The correlations of serum irisin with adiposity markers measurements were determined. The statistical evaluation was conducted using a parametric linear correlation approach. Serum irisin levels, quantified in ng/mL, positively correlated with several adiposity indicators. Notably, there was a meaningful relationship with body weight in kilograms (r = 0.385, p = 0.014), body mass index (BMI) (r = 0.588, p ≤ 0.001), body fat percentage (r = 0.450, p = 0.004), total fat mass in kilograms (r = 0.342, p = 0.031), and lean body mass in kilograms (r = 0.344, p = 0.029). Furthermore, waist circumference in centimeters (r = 0.329, p = 0.038), hip circumference in centimeters (r = 0.321, p = 0.043), and the waist-to-hip ratio (r = 0.447, p = 0.004) also demonstrated positive correlations with irisin concentrations. Conversely, body height in meters showed no significant correlation (r = -0.003, p ≥ 0.05). Serum irisin’s relationship with adiposity markers is evident, yet it does not extend to body height. Interrelationships among adiposity markers might influence serum irisin in obese women after single-session exercise.

Keywords: Serum irisin, adiposity markers, female, obesity.

References

Aktar, N., Qureshi, N. K., Ferdous, H. S. (2017). Obesity: A Review of Pathogenesis and Management Strategies in Adult. Delta Medical College Journal, 5(1), 35-48. https://doi.org/10.3329/dmcj.v5i1.31436.

Akter, S., Rahman, M. M., Abe, S. K., & Sultana, P. (2014). Prevalence of diabetes and prediabetes and their risk factors among Bangladeshi adults: a nationwide survey. Bulletin of the World Health Organization, 92(3), 204–213A. https://doi.org/10.2471/BLT.13.128371.

Al-Daghri, N. M., Alokail, M. S., Rahman, S., Amer, O. E., Al-Attas, O. S., Alfawaz, H., Tripathi, G., Sabico, S., Chrousos, G. P., McTernan, P. G., & Piya, M. K. (2015). Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2. European journal of clinical investigation, 45(8), 775–781. https://doi.org/10.1111/eci.12468.

Al Kibria G. M. (2019). Prevalence and factors affecting underweight, overweight and obesity using Asian and World Health Organization cutoffs among adults in Nepal: Analysis of the Demographic and Health Survey 2016. Obesity research & clinical practice, 13(2), 129–136. https://doi.org/10.1016/j.orcp.2019.01.006.

Anastasilakis, A. D., Polyzos, S. A., Saridakis, Z. G., Kynigopoulos, G., Skouvaklidou, E. C., Molyvas, D., Vasiloglou, M. F., Apostolou, A., Karagiozoglou-Lampoudi, T., Siopi, A., Mougios, V., Chatzistavridis, P., Panagiotou, G., Filip-paios, A., Delaroudis, S., & Mantzoros, C. S. (2014). Circulating irisin in healthy, young individuals: day-night rhythm, effects of food intake and exercise, and associations with gender, physical activity, diet, and body composi-tion. The Journal of clinical endocrinology and metabolism, 99(9), 3247–3255. https://doi.org/10.1210/jc.2014-1367.

Basic Health Research. (2018). National Report on Basic Health Research. Jakarta: Kemenkes RI. 2018. Available at: http://www.kesmas.kemkes.go.id.

Blüher, S., Panagiotou, G., Petroff, D., Markert, J., Wagner, A., Klemm, T., Filippaios, A., Keller, A., & Mantzoros, C. S. (2014). Effects of a 1-year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children. Obesity (Silver Spring, Md.), 22(7), 1701–1708. https://doi.org/10.1002/oby.20739.

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., Kajimura, S., Zingaretti, M. C., Vind, B. F., Tu, H., Cinti, S., Højlund, K., Gygi, S. P., & Spiegelman, B. M. (2012). A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 481(7382), 463–468. https://doi.org/10.1038/nature10777.

Buscemi, S., Corleo, D., Vasto, S., Buscemi, C., Massenti, M. F., Nuzzo, D., Lucisano, G., Barile, A. M., Rosafio, G., Maniaci, V., & Giordano, C. (2018). Factors associated with circulating concentrations of irisin in the general popula-tion cohort of the ABCD study. International journal of obesity (2005), 42(3), 398–404. https://doi.org/10.1038/ijo.2017.255.

Crujeiras, A. B., Pardo, M., Arturo, R. R., Navas-Carretero, S., Zulet, M. A., Martínez, J. A., & Casanueva, F. F. (2014). Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women. American journal of human biology : the official journal of the Human Biology Coun-cil, 26(2), 198–207. https://doi.org/10.1002/ajhb.22493.

Elizondo-Montemayor, L., Silva-Platas, C., Torres-Quintanilla, A., Rodríguez-López, C., Ruiz-Esparza, G. U., Reyes-Mendoza, E., & Garcia-Rivas, G. (2017). Association of Irisin Plasma Levels with Anthropometric Parameters in Children with Underweight, Normal Weight, Overweight, and Obesity. BioMed research international, 2017, 2628968. https://doi.org/10.1155/2017/2628968.

Ellefsen, S., Vikmoen, O., Slettaløkken, G., Whist, J. E., Nygaard, H., Hollan, I., Rauk, I., Vegge, G., Strand, T. A., Raastad, T., & Rønnestad, B. R. (2014). Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women. European journal of applied physiology, 114(9), 1875–1888. https://doi.org/10.1007/s00421-014-2922-x.

Fan, W., & Evans, R. M. (2017). Exercise Mimetics: Impact on Health and Performance. Cell metabolism, 25(2), 242–247. https://doi.org/10.1016/j.cmet.2016.10.022.

Fatouros I. G. (2018). Is irisin the new player in exercise-induced adaptations or not? A 2017 update. Clinical chemistry and laboratory medicine, 56(4), 525–548. https://doi.org/10.1515/cclm-2017-0674.

GBD 2015 Obesity Collaborators, Afshin, A., Forouzanfar, M. H., Reitsma, M. B., Sur, P., Estep, K., Lee, A., Marczak, L., Mokdad, A. H., Moradi-Lakeh, M., Naghavi, M., Salama, J. S., Vos, T., Abate, K. H., Abbafati, C., Ahmed, M. B., Al-Aly, Z., Alkerwi, A., Al-Raddadi, R., Amare, A. T., … Murray, C. J. L. (2017). Health Effects of Overweight and Obesity in 195 Countries over 25 Years. The New England journal of medicine, 377(1), 13–27. https://doi.org/10.1056/NEJMoa1614362.

Gonzalez-Gil, A. M., Peschard-Franco, M., Castillo, E. C., Gutierrez-DelBosque, G., Treviño, V., Silva-Platas, C., Pe-rez-Villarreal, L., Garcia-Rivas, G., & Elizondo-Montemayor, L. (2019). Myokine-adipokine cross-talk: potential mechanisms for the association between plasma irisin and adipokines and cardiometabolic risk factors in Mexican children with obesity and the metabolic syndrome. Diabetology & metabolic syndrome, 11, 63. https://doi.org/10.1186/s13098-019-0458-2.

Hecksteden, A., Wegmann, M., Steffen, A., Kraushaar, J., Morsch, A., Ruppenthal, S., Kaestner, L., & Meyer, T. (2013). Irisin and exercise training in humans - results from a randomized controlled training trial. BMC medicine, 11, 235. https://doi.org/10.1186/1741-7015-11-235.

Hernández Bautista, R. J., Mahmoud, A. M., Königsberg, M., & López Díaz Guerrero, N. E. (2019). Obesity: Patho-physiology, monosodium glutamate-induced model and anti-obesity medicinal plants. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 111, 503–516. https://doi.org/10.1016/j.biopha.2018.12.108.

Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012). FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expres-sion and circulating concentrations in response to weight loss and exercise. Metabolism: clinical and experi-mental, 61(12), 1725–1738. https://doi.org/10.1016/j.metabol.2012.09.002.

Jameel, F., Thota, R.N., Wood, L.G., Plunkett, B., & Garg, M.L. (2015). Sex-dependent association between circulating irisin levels and insulin resistance in healthy adults. Journal of Nutrition & Intermediary Metabolism, 2(3–4), 86-92. https://doi.org/10.1016/j.jnim.2015.10.001.

Jang, H. B., Kim, H. J., Kang, J. H., Park, S. I., Park, K. H., & Lee, H. J. (2017). Association of circulating irisin levels with metabolic and metabolite profiles of Korean adolescents. Metabolism: clinical and experimental, 73, 100–108. https://doi.org/10.1016/j.metabol.2017.05.007.

Khan, S., & Shah, A.J. (2017). Causes and Complication of Obesity among the Children International Journal of Nutrition and Health Sciences Causes and Complication of Obesity among the Children. Acta Scientific Nutritional Health, 1(1), 47-50.

Kim, H. J., So, B., Choi, M., Kang, D., & Song, W. (2015). Resistance exercise training increases the expression of irisin concomitant with improvement of muscle function in aging mice and humans. Experimental gerontology, 70, 11–17. https://doi.org/10.1016/j.exger.2015.07.006.

Kim, H. J., Lee, H. J., So, B., Son, J. S., Yoon, D., & Song, W. (2016). Effect of aerobic training and resistance training on circulating irisin level and their association with change of body composition in overweight/obese adults: a pilot study. Physiological research, 65(2), 271–279. https://doi.org/10.33549/physiolres.932997.

Lim, J. U., Lee, J. H., Kim, J. S., Hwang, Y. I., Kim, T. H., Lim, S. Y., Yoo, K. H., Jung, K. S., Kim, Y. K., & Rhee, C. K. (2017). Comparison of World Health Organization and Asia-Pacific body mass index classifications in COPD patients. International journal of chronic obstructive pulmonary disease, 12, 2465–2475. https://doi.org/10.2147/COPD.S141295.

Liu, J. J., Wong, M. D., Toy, W. C., Tan, C. S., Liu, S., Ng, X. W., Tavintharan, S., Sum, C. F., & Lim, S. C. (2013). Lower circulating irisin is associated with type 2 diabetes mellitus. Journal of diabetes and its complications, 27(4), 365–369. https://doi.org/10.1016/j.jdiacomp.2013.03.002.

Löffler, D., Müller, U., Scheuermann, K., Friebe, D., Gesing, J., Bielitz, J., Erbs, S., Landgraf, K., Wagner, I. V., Kiess, W., & Körner, A. (2015). Serum irisin are regulated by acute strenuous exercise. The Journal of clinical endocri-nology and metabolism, 100(4), 1289–1299. https://doi.org/10.1210/jc.2014-2932.

Murawska-Cialowicz, E., Wojna, J., & Zuwala-Jagiello, J. (2015). Crossfit training changes brain-derived neurotrophic factor and irisin levels at rest, after wingate and progressive tests, and improves aerobic capacity and body composi-tion of young physically active men and women. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 66(6), 811–821.

Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., Gulseth, H. L., Birkeland, K. I., Jensen, J., & Drevon, C. A. (2014). The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans. The FEBS journal, 281(3), 739–749. https://doi.org/10.1111/febs.12619.

Pardo, M., Crujeiras, A. B., Amil, M., Aguera, Z., Jiménez-Murcia, S., Baños, R., Botella, C., de la Torre, R., Estivill, X., Fagundo, A. B., Fernández-Real, J. M., Fernández-García, J. C., Fruhbeck, G., Gómez-Ambrosi, J., Rodríguez, R., Tinahones, F. J., Fernández-Aranda, F., & Casanueva, F. F. (2014). Association of irisin with fat mass, resting en-ergy expenditure, and daily activity in conditions of extreme body mass index. International journal of endocrinology, 2014, 857270. https://doi.org/10.1155/2014/857270.

Pedersen, B. K., & Febbraio, M. A. (2012). Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nature reviews. Endocrinology, 8(8), 457–465. https://doi.org/10.1038/nrendo.2012.49.

Perakakis, N., Triantafyllou, G. A., Fernández-Real, J. M., Huh, J. Y., Park, K. H., Seufert, J., & Mantzoros, C. S. (2017). Physiology and role of irisin in glucose homeostasis. Nature reviews. Endocrinology, 13(6), 324–337. https://doi.org/10.1038/nrendo.2016.221.

Rambhojan, C., Bouaziz-Amar, E., Larifla, L., Deloumeaux, J., Clepier, J., Plumasseau, J., Lacorte, J. M., & Foucan, L. (2015). Ghrelin, adipokines, metabolic factors in relation with weight status in school-children and results of a 1-year lifestyle intervention program. Nutrition & metabolism, 12, 43. https://doi.org/10.1186/s12986-015-0039-9.

Raharjo, S. ., Giang, N. T., Azidin, R. M. F. R., Fitri, M., Yunus, M., & Pelana, R. (2024). Long-Term High-Intensity Plyometric Training Increases Muscle Strength and Power of The Lower Body in Young Healthy Males. Retos, 57, 324–329. https://doi.org/10.47197/retos.v57.104733.

Rejeki, P. S., Pranoto, A., Widiatmaja, D. M., Utami, D. M., Izzatunnisa, N., Sugiharto, Lesmana, R., & Halim, S. (2024). Combined Aerobic Exercise with Intermittent Fasting Is Effective for Reducing mTOR and Bcl-2 Levels in Obese Females. Sports (Basel, Switzerland), 12(5), 116. https://doi.org/10.3390/sports12050116.

Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Belén Crujeiras, A., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013). FNDC5/irisin is not only a myokine but also an adipokine. PLoS One, 8(4), e60563. https://doi.org/10.1371/journal.pone.0060563.

Rosella, L. C., Kornas, K., Huang, A., Grant, L., Bornbaum, C., & Henry, D. (2019). Population risk and burden of health behavioral-related all-cause, premature, and amenable deaths in Ontario, Canada: Canadian Community Health Survey-linked mortality files. Annals of epidemiology, 32, 49–57.e3. https://doi.org/10.1016/j.annepidem.2019.01.009.

Sahin-Efe, A., Upadhyay, J., Ko, B. J., Dincer, F., Park, K. H., Migdal, A., Vokonas, P., & Mantzoros, C. (2018). Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes: A cross sectional and a prospective case-control study nested in the Normative Aging Study. Metabolism: clinical and experimental, 79, 24–32. https://doi.org/10.1016/j.metabol.2017.10.011.

Shoukry, A., Shalaby, S. M., El-Arabi Bdeer, S., Mahmoud, A. A., Mousa, M. M., & Khalifa, A. (2016). Circulating serum irisin in obesity and type 2 diabetes mellitus. IUBMB life, 68(7), 544–556. https://doi.org/10.1002/iub.1511.

Siantoro, G., Kartiko, D. C., Muhammad, M., Phanpheng, Y., Pramono, B. A., Kusuma, I. D. M. A. W., Triardhana, Y. A., Lestari, B., Samudra, F. E., & Pranoto, A. (2024). Moderate-intensity endurance training has higher effects sup-pression of oxidative stress secretion than strength training in obese students. Retos, 57, 291–297. https://doi.org/10.47197/retos.v57.105307.

Spinelli, A., Buoncristiano, M., Kovacs, V. A., Yngve, A., Spiroski, I., Obreja, G., Starc, G., Pérez, N., Rito, A. I., Kunešová, M., Sant'Angelo, V. F., Meisfjord, J., Bergh, I. H., Kelleher, C., Yardim, N., Pudule, I., Petrauskiene, A., Duleva, V., Sjöberg, A., Gualtieri, A., … Breda, J. (2019). Prevalence of Severe Obesity among Primary School Children in 21 European Countries. Obesity facts, 12(2), 244–258. https://doi.org/10.1159/000500436.

Stengel, A., Hofmann, T., Goebel-Stengel, M., Elbelt, U., Kobelt, P., & Klapp, B. F. (2013). Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity--correlation with body mass index. Peptides, 39, 125–130. https://doi.org/10.1016/j.peptides.2012.11.014.

Susanto, H., Sugiharto, Taufiq, A., Pranoto, A., & Dwi Trijoyo Purnomo, J. (2023). Dynamic alteration of plasma levels of betatrophin in younger female onset obesity post acute moderate-intensity exercise training. Saudi journal of biologi-cal sciences, 30(2), 103546. https://doi.org/10.1016/j.sjbs.2022.103546.

Tabak, O., Simsek, G., Erdenen, F., Sozer, V., Hasoglu, T., Gelisgen, R., Altunoglu, E., Muderrisoglu, C., Senyigit, A., & Uzun, H. (2017). The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflamma-tory mediators in patients with metabolic syndrome. Archives of endocrinology and metabolism, 61(6), 515–523. https://doi.org/10.1590/2359-3997000000289.

Tang, L., Tong, Y., Zhang, F., Chen, G., Zhang, Y. C., Jobin, J., & Tong, N. (2019). The association of circulating irisin with metabolic risk factors in Chinese adults: a cross-sectional community-based study. BMC endocrine disorders, 19(1), 147. https://doi.org/10.1186/s12902-019-0479-8.

Tsuchiya, Y., Ando, D., Goto, K., Kiuchi, M., Yamakita, M., & Koyama, K. (2014). High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption. The Tohoku journal of experimental medicine, 233(2), 135–140. https://doi.org/10.1620/tjem.233.135.

WHO Expert Consultation (2004). Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet (London, England), 363(9403), 157–163. https://doi.org/10.1016/S0140-6736(03)15268-3.

World Health Organization (WHO) (2022). Obesity. Geneva: WHO Press. Available at: https://www.who.int/health-topics/obesity#tab=tab_1.

Yin, C., Hu, W., Wang, M., Lv, W., Jia, T., & Xiao, Y. (2020). Irisin as a mediator between obesity and vascular in-flammation in Chinese children and adolescents. Nutrition, metabolism, and cardiovascular diseases : NMCD, 30(2), 320–329. https://doi.org/10.1016/j.numecd.2019.09.025.

Zhang, R., Fu, T., Zhao, X., Qiu, Y., Hu, X., Shi, H., & Yin, X. (2020). Association of Circulating Irisin Levels with Adiposity and Glucose Metabolic Profiles in a Middle-Aged Chinese Population: A Cross-Sectional Study. Diabetes, metabolic syndrome and obesity : targets and therapy, 13, 4105–4112. https://doi.org/10.2147/DMSO.S275878.

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2024-07-16

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Bayu Agung Pramono, Pranoto, A., Kusuma, I. D. M. A. W., Yosika, G. F., & Phanpheng, Y. (2024). Serum irisin is positively associated with adiposity markers in obese women after single-session exercise-induced. Retos, 58, 584–591. https://doi.org/10.47197/retos.v58.106845

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