Efectos del ejercicio combinado de intensidad moderada sobre el aumento de los niveles de adiponectina, la masa muscular y la disminución de la masa grasa en mujeres obesas (Effects of moderate-intensity combination exercise on increase adiponectin levels, muscle mass, and decrease fat mass in obese women)
DOI:
https://doi.org/10.47197/retos.v55.103738Palabras clave:
Obesity, combination exercise, adiponectin levels, body compositionResumen
Se informa que la obesidad está fuertemente asociada con niveles bajos de adiponectina, que puede estar implicada en el síndrome metabólico, la resistencia a la insulina, las enfermedades cardiovasculares, la hipertensión y la proliferación de células cancerosas. Mientras tanto, se ha informado que el ejercicio físico aumenta los niveles de adiponectina y disminuye la resistencia a la insulina en personas obesas. Por lo tanto, este estudio tuvo como objetivo probar los efectos de cuatro semanas de ejercicio combinado de intensidad moderada (aeróbico y de resistencia) sobre el aumento de los niveles de adiponectina, la masa del músculo esquelético (SMM) y la disminución de la masa grasa (FM) en mujeres obesas. Se seleccionaron como sujetos de investigación un total de 14 mujeres adolescentes obesas de entre 20 y 24 años con un índice de masa corporal (IMC) de 27.5 a 36.5 kg/m2 (según la clasificación del IMC de Asia y el Pacífico) y se dividieron en dos grupos de intervención: control (CON) y grupos de ejercicio combinado de intensidad moderada (MCE). Se utilizó el método del kit ELISA para analizar los niveles de adiponectina antes y después del ejercicio, mientras que el mBCA 554 seca se utilizó para medir el IMC, la FM y el SMM. El análisis estadístico se realizó mediante una prueba t para muestras independientes con un nivel de significancia del 5%. Los datos mostraron ∆-IMC entre CON y MCE (0.54±0.99 vs -1.31±0.19 kg/m2; p = 0.001), ∆-FM (1.56±3.89 vs -3.60±1.16 kg; p = 0.006), ∆-SMM (-0.85±1.91 vs 3.61±0.74 kg; p = 0.001), ∆-Adiponectina (0.55±2.39 vs 15.45±6.21 ng/mL; p = 0.001). Los resultados demuestran que una intervención de ejercicio combinado de intensidad moderada durante 4 semanas aumenta eficazmente los niveles de adiponectina y la masa del músculo esquelético y reduce el índice de masa corporal y la masa grasa en mujeres obesas.
Palabras clave: Obesidad, ejercicio combinado, niveles de adiponectina, composición corporal.
Abstract. Obesity is reported to be strongly associated with low levels of adiponectin, which may be involved in metabolic syndrome, insulin resistance, cardiovascular disease, hypertension, and cancer cell proliferation. Meanwhile, physical exercise has been reported to increase adiponectin levels and decrease insulin resistance in obese individuals. Therefore, this study aimed to prove the effects of four weeks of moderate-intensity combination exercise (aerobic and resistance) on increasing adiponectin levels, skeletal muscle mass (SMM), and decreasing fat mass (FM) in obese women. A total of 14 obese adolescent women aged 20-24 years with a body mass index (BMI) of 27.5-36.5 kg/m2 (based on Asia-Pacific BMI classification) were selected as research subjects and divided into two intervention groups: control (CON) and moderate-intensity combination exercise (MCE) groups. The ELISA kit method was used to analyze pre- and post-exercise adiponectin levels, while the mBCA 554 seca was used to measure BMI, FM, and SMM. Statistical analysis was performed using an independent samples t-test with a 5% significance level. The data showed ∆-BMI between CON and MCE (0.54±0.99 vs -1.31±0.19 kg/m2; p = 0.001), ∆-FM (1.56±3.89 vs -3.60±1.16 kg; p = 0.006), ∆-SMM (-0.85±1.91 vs 3.61±0.74 kg; p = 0.001), ∆-Adiponectin (0.55±2.39 vs 15.45±6.21 ng/mL; p = 0.001). The results demonstrate that a 4-week moderate-intensity combination exercise intervention effectively increases adiponectin levels and skeletal muscle mass and reduces body mass index and fat mass in obese women.
Keywords: Obesity, combination exercise, adiponectin levels, body composition.
Citas
Akbarpour M. (2013). The effect of aerobic training on serum adiponectin and leptin levels and inflammatory markers of coronary heart disease in obese men. Biology of sport, 30(1), 21–27. https://doi.org/10.5604/20831862.1029817.
Alebna, P. L., Mehta, A., Yehya, A., daSilva-deAbreu, A., Lavie, C. J., & Carbone, S. (2024). Update on obesity, the obesity paradox, and obesity management in heart failure. Progress in cardiovascular diseases, S0033-0620(24)00003-3. Advance online publication. https://doi.org/10.1016/j.pcad.2024.01.003.
Bailey, C. J., Flatt, P. R., & Conlon, J. M. (2024). Recent advances in peptide-based therapies for obesity and type 2 diabetes. Peptides, 173, 171149. https://doi.org/10.1016/j.peptides.2024.171149.
Becic, T., Studenik, C., & Hoffmann, G. (2018). Exercise Increases Adiponectin and Reduces Leptin Levels in Prediabetic and Diabetic Individuals: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medical sciences (Basel, Switzerland), 6(4), 97. https://doi.org/10.3390/medsci6040097.
Bharath, L. P., Choi, W. W., Cho, J. M., Skobodzinski, A. A., Wong, A., Sweeney, T. E., & Park, S. Y. (2018). Combined resistance and aerobic exercise training reduces insulin resistance and central adiposity in adolescent girls who are obese: randomized clinical trial. European journal of applied physiology, 118(8), 1653–1660. https://doi.org/10.1007/s00421-018-3898-8.
Brunelli, D. T., Chacon-Mikahil, M. P., Gáspari, A. F., Lopes, W. A., Bonganha, V., Bonfante, I. L., Bellotto, M. L., Libardi, C. A., & Cavaglieri, C. R. (2015). Combined Training Reduces Subclinical Inflammation in Obese Middle-Age Men. Medicine and science in sports and exercise, 47(10), 2207–2215. https://doi.org/10.1249/MSS.0000000000000658.
Chung, H. S., & Choi, K. M. (2018). Adipokines and Myokines: A Pivotal Role in Metabolic and Cardiovascular Disorders. Current medicinal chemistry, 25(20), 2401–2415. https://doi.org/10.2174/0929867325666171205144627.
Clemente-Suárez, V. J., Redondo-Flórez, L., Beltrán-Velasco, A. I., Martín-Rodríguez, A., Martínez-Guardado, I., Navarro-Jiménez, E., Laborde-Cárdenas, C. C., & Tornero-Aguilera, J. F. (2023). The Role of Adipokines in Health and Disease. Biomedicines, 11(5), 1290. https://doi.org/10.3390/biomedicines11051290.
Dieli-Conwright, C. M., Courneya, K. S., Demark-Wahnefried, W., Sami, N., Lee, K., Buchanan, T. A., Spicer, D. V., Tripathy, D., Bernstein, L., & Mortimer, J. E. (2018). Effects of Aerobic and Resistance Exercise on Metabolic Syndrome, Sarcopenic Obesity, and Circulating Biomarkers in Overweight or Obese Survivors of Breast Cancer: A Randomized Controlled Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 36(9), 875–883. https://doi.org/10.1200/JCO.2017.75.7526.
Egan, B., & Zierath, J. R. (2013). Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell metabolism, 17(2), 162–184. https://doi.org/10.1016/j.cmet.2012.12.012Egan, B., & Zierath, J. R. (2013). Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell metabolism, 17(2), 162–184. https://doi.org/10.1016/j.cmet.2012.12.012.
González-Muniesa, P., Mártinez-González, M. A., Hu, F. B., Després, J. P., Matsuzawa, Y., Loos, R. J. F., Moreno, L. A., Bray, G. A., & Martinez, J. A. (2017). Obesity. Nature reviews. Disease primers, 3, 17034. https://doi.org/10.1038/nrdp.2017.34.
Grant, B., Sandelson, M., Agyemang-Prempeh, B., & Zalin, A. (2021). Managing obesity in people with type 2 diabetes. Clinical medicine (London, England), 21(4), e327–e231. https://doi.org/10.7861/clinmed.2021-0370.
He, L., Xuan, W., Liu, D., Zhong, J., Luo, H., Cui, H., Zhang, X., & Chen, W. (2024). The role of adiponectin in the association between abdominal obesity and type 2 diabetes: a mediation analysis among 232,438 Chinese participants. Frontiers in Endocrinology, 15, 1327716. https://doi.org/10.3389/fendo.2024.1327716.
Jeon, J. Y., Han, J., Kim, H. J., Park, M. S., Seo, D. Y., & Kwak, Y. S. (2013). The combined effects of physical exercise training and detraining on adiponectin in overweight and obese children. Integrative medicine research, 2(4), 145–150. https://doi.org/10.1016/j.imr.2013.10.001.
Jiménez-Martínez, P., Ramirez-Campillo, R., Alix-Fages, C., Gene-Morales, J., García-Ramos, A., & Colado, J. C. (2023). Chronic Resistance Training Effects on Serum Adipokines in Type 2 Diabetes Mellitus: A Systematic Review. Healthcare (Basel, Switzerland), 11(4), 594. https://doi.org/10.3390/healthcare11040594.
Khalafi, M., Habibi Maleki, A., Sakhaei, M. H., Rosenkranz, S. K., Pourvaghar, M. J., Ehsanifar, M., Bayat, H., Korivi, M., & Liu, Y. (2023). The effects of exercise training on body composition in postmenopausal women: a systematic review and meta-analysis. Frontiers in endocrinology, 14, 1183765. https://doi.org/10.3389/fendo.2023.1183765.
Landecho, M. F., Marin-Oto, M., Recalde-Zamacona, B., Bilbao, I., & Frühbeck, G. (2021). Obesity as an adipose tissue dysfunction disease and a risk factor for infections - Covid-19 as a case study. European journal of internal medicine, 91, 3–9. https://doi.org/10.1016/j.ejim.2021.03.031.
Landecho, M. F., Tuero, C., Valentí, V., Bilbao, I., de la Higuera, M., & Frühbeck, G. (2019). Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk. Nutrients, 11(11), 2664. https://doi.org/10.3390/nu11112664.
Leal, L. G., Lopes, M. A., & Batista, M. L., Jr (2018). Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases. Frontiers in physiology, 9, 1307. https://doi.org/10.3389/fphys.2018.01307.
Liu, Z., Wu, K. K. L., Jiang, X., Xu, A., & Cheng, K. K. Y. (2020). The role of adipose tissue senescence in obesity- and ageing-related metabolic disorders. Clinical science (London, England : 1979), 134(2), 315–330. https://doi.org/10.1042/CS20190966.
Lopes, W. A., Leite, N., da Silva, L. R., Brunelli, D. T., Gáspari, A. F., Radominski, R. B., Chacon-Mikahil, M. P., & Cavaglieri, C. R. (2016). Effects of 12 weeks of combined training without caloric restriction on inflammatory markers in overweight girls. Journal of sports sciences, 34(20), 1902–1912. https://doi.org/10.1080/02640414.2016.1142107.
Muscella, A., Stefàno, E., Lunetti, P., Capobianco, L., & Marsigliante, S. (2020). The Regulation of Fat Metabolism During Aerobic Exercise. Biomolecules, 10(12), 1699. https://doi.org/10.3390/biom10121699.
Nguyen T. M. D. (2020). Adiponectin: Role in Physiology and Pathophysiology. International journal of preventive medicine, 11, 136. https://doi.org/10.4103/ijpvm.IJPVM_193_20.
Parida, S., Siddharth, S., & Sharma, D. (2019). Adiponectin, Obesity, and Cancer: Clash of the Bigwigs in Health and Disease. International journal of molecular sciences, 20(10), 2519. https://doi.org/10.3390/ijms20102519.
Park, K. M., Park, S. C., & Kang, S. (2019). Effects of resistance exercise on adipokine factors and body composition in pre- and postmenopausal women. Journal of exercise rehabilitation, 15(5), 676–682. https://doi.org/10.12965/jer.1938368.184.
Pedersen B. K. (2011). Muscles and their myokines. The Journal of experimental biology, 214(Pt 2), 337–346. https://doi.org/10.1242/jeb.048074.
Pellegrinelli, V., Carobbio, S., & Vidal-Puig, A. (2016). Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues. Diabetologia, 59(6), 1075–1088. https://doi.org/10.1007/s00125-016-3933-4.
Pranoto, A., Cahyono, M. B. A., Yakobus, R., Izzatunnisa, N., Ramadhan, R. N., Rejeki, P. S., Miftahussurur, M., Effendi, W. I., Wungu, C. D. K., & Yamaoka, Y. (2023). Long-Term Resistance-Endurance Combined Training Reduces Pro-Inflammatory Cytokines in Young Adult Females with Obesity. Sports (Basel, Switzerland), 11(3), 54. https://doi.org/10.3390/sports11030054.
Pranoto, A., Ramadhan, R. N., Rejeki, P. S., Miftahussurur, M., Yosika, G. F., Nindya, T. S., Lestari, B., & Halim, S. (2024). The role of long-term combination training in reducing and maintaining of body fat in obese young adult women. Retos, 53, 139–146. https://doi.org/10.47197/retos.v53.102460.
Rejeki, P. S., Pranoto, A., Rahmanto, I., Izzatunnisa, N., Yosika, G. F., Hernaningsih, Y., Wungu, C. D. K., & Halim, S. (2023). The Positive Effect of Four-Week Combined Aerobic-Resistance Training on Body Composition and Adipokine Levels in Obese Females. Sports (Basel, Switzerland), 11(4), 90. https://doi.org/10.3390/sports11040090.
Robinson, K., Prins, J., & Venkatesh, B. (2011). Clinical review: adiponectin biology and its role in inflammation and critical illness. Critical care (London, England), 15(2), 221. https://doi.org/10.1186/cc10021.
Sari, A. R., Risdayanto, R. D., Pradipta, M. H., Qorni, U. A., Rejeki, P. S., Argarini, R., Halim, S., & Pranoto, A. (2024). Impact of Time-Resricted Feeding and Aerobic Exercise Combination on Promotes Myokine Levels and Improve Body Composition in Obese Women. Retos, 53, 1–10. https://doi.org/10.47197/retos.v53.102429.
Strasser, B., Arvandi, M., & Siebert, U. (2012). Resistance training, visceral obesity and inflammatory response: a review of the evidence. Obesity reviews : an official journal of the International Association for the Study of Obesity, 13(7), 578–591. https://doi.org/10.1111/j.1467-789X.2012.00988.x.
Tanaka, Y., Kita, S., Nishizawa, H., Fukuda, S., Fujishima, Y., Obata, Y., Nagao, H., Masuda, S., Nakamura, Y., Shimizu, Y., Mineo, R., Natsukawa, T., Funahashi, T., Ranscht, B., Fukada, S. I., Maeda, N., & Shimomura, I. (2019). Adiponectin promotes muscle regeneration through binding to T-cadherin. Scientific reports, 9(1), 16. https://doi.org/10.1038/s41598-018-37115-3.
Unamuno, X., Gómez-Ambrosi, J., Rodríguez, A., Becerril, S., Frühbeck, G., & Catalán, V. (2018). Adipokine dysregulation and adipose tissue inflammation in human obesity. European journal of clinical investigation, 48(9), e12997. https://doi.org/10.1111/eci.12997.
Wang, Q. A., Tao, C., Gupta, R. K., & Scherer, P. E. (2013). Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nature medicine, 19(10), 1338–1344. https://doi.org/10.1038/nm.3324.
Wang, S., Zhou, H., Zhao, C., & He, H. (2022). Effect of Exercise Training on Body Composition and Inflammatory Cytokine Levels in Overweight and Obese Individuals: A Systematic Review and Network Meta-Analysis. Frontiers in immunology, 13, 921085. https://doi.org/10.3389/fimmu.2022.921085.
Yamauchi, T., & Kadowaki, T. (2013). Adiponectin receptor as a key player in healthy longevity and obesity-related diseases. Cell metabolism, 17(2), 185–196. https://doi.org/10.1016/j.cmet.2013.01.001.
Zaidi, H., Byrkjeland, R., Njerve, I. U., Åkra, S., Solheim, S., Arnesen, H., Seljeflot, I., & Opstad, T. B. (2021). Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease. Adipocyte, 10(1), 612–620. https://doi.org/10.1080/21623945.2021.1996699.
Zhang, L., Lv, J., Wang, C., Ren, Y., & Yong, M. (2023). Myokine, a key cytokine for physical exercise to alleviate sarcopenic obesity. Molecular biology reports, 50(3), 2723–2734. https://doi.org/10.1007/s11033-022-07821-3.
Zhang, Y., Wu, Y., Fei, X., Li, Y., Li, Y., & Yan, X. (2023). Effects of Aerobic Exercise on Serum Adiponectin Concentrations in Children and Adolescents with Obesity: A Systematic Review and Meta-Analysis. Life (Basel, Switzerland), 13(8), 1772. https://doi.org/10.3390/life13081772.
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