O exercício aeróbico aumenta a liberação do hormônio do crescimento na circulação sanguínea em mulheres obesas

Autores

  • Adi Pranoto Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga https://orcid.org/0000-0003-4080-9245
  • Purwo Sri Rejeki Department of Medical Physiology and Biochemistry, Faculty of Medicine, Universitas Airlangga https://orcid.org/0000-0002-6285-4058
  • Muhammad Miftahussurur Division of Gastroenterology-Hepatology, Department of Internal Medicine, Faculty of Medicine Universitas Airlangga - Dr. Soetomo Teaching Hospital - Institute of Tropical Disease
  • Ghana Firsta Yosika Study Program of Sports Coaching Education, Faculty of Teacher Training and Education, Universitas Tanjungpura
  • Mufarrihul Ihsan Sport Health Science, Faculty of Medicine, Universitas Airlangga
  • Lilik Herawati Physiology Division, Department of Medical Physiology and Biochemistry, Faculty of Medicine, Universitas Airlangga
  • Ilham Rahmanto Medical Program, Faculty of Medicine, Universitas Airlangga https://orcid.org/0000-0003-0916-5824
  • Shariff Halim Faculty of Health Sciences, University Technology MARA (UiTM) Pulau Pinang

DOI:

https://doi.org/10.47197/retos.v51.99944

Palavras-chave:

aerobic exercise, growth hormone, metabolism, obesity

Resumo

O exercício físico é um dos moduladores de aumento da liberação dos níveis do hormônio do crescimento (GH) na circulação sanguínea, mas ainda se está debatendo qual é o modelo de exercício eficaz para indivíduos obesos. Portanto, este estudo tem como objetivo demonstrar o efeito do exercício aeróbico sobre o aumento da liberação de níveis de GH na circulação sanguínea em mulheres obesas. Um total de 20 mulheres adultas obesas, com idades de 21,00 ± 1,08 anos, foram selecionadas para participar do estúdio e realizaram uma intervenção de exercício aeróbico correndo em uma cinta rodante de intensidade moderada (60-70% FCmáx ) durante 40 minutos. Foi utilizado o método ELISA para medir a liberação de níveis de GH em todas as demonstrações (antes e depois do exercício). A análise estadística neste estúdio utilizou uma tentativa de exibição independente com um nível significativo de 5%. Os resultados mostram que a liberação de níveis de GH na circulação sanguínea foi maior no pós-exercício em comparação com o pré-exercício após uma sessão de exercício aeróbico (484,92±128,29 vs 892,63±273, 54 pg/mL; p=0,001) e tem um tamanho de efeito grande com um valor de Cohen de 1.909. Também foi encontrado que os níveis de GH na circulação sanguínea pós-ejeção no grupo de exercício aeróbico (Exr) eram mais altos que os níveis de GH no grupo de controle (Ctr) (892,63 ± 273,54 vs 542 ,97 ± 140,01 pg/mL; p = 0,003). e tem um tamanho de efeito grande com um valor de Cohen de 1.609. Este estudo demonstrou que uma sessão de exercício aeróbico de intensidade moderada aumenta a liberação de níveis circulantes de GH em mulheres obesas. Por isso, o exercício aeróbico de intensidade moderada pode ser usado como uma opção de terapia alternativa para aumentar a liberação dos níveis circulantes de GH em pessoas com obesidade.

Palavras-chave: exercício aeróbico, hormônio do crescimento, metabolismo, obesidade.

Referências

Al-Samerria, S., & Radovick, S. (2021). The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of Growth. Cells, 10(10), 2664. https://doi.org/10.3390/cells10102664.

Alvarez, C. E., Herrera Monge, M. F., Herrera González, E., Villalobos Víquez, G., & Araya Vargas, G. (2020). Sobrepeso, obesidad, niveles de actividad física y autoestima de la niñez centroamericana: un análisis comparativo entre países (Overweight, obesity, physical activity levels, and self-esteem in Central American children: comparative analysis between cou. Retos, 37, 238–246. https://doi.org/10.47197/retos.v37i37.71680.

Berry, N. T., Hubal, M., & Wideman, L. (2018). The effects of an acute exercise bout on GH and IGF-1 in prediabetic and healthy African Americans: A pilot study investigating gene expression. PloS one, 13(1), e0191331. https://doi.org/10.1371/journal.pone.0191331.

Blüher, M. (2019). Obesity: global epidemiology and pathogenesis. Nature reviews. Endocrinology, 15(5), 288–298. https://doi.org/10.1038/s41574-019-0176-8.

Camacho, S., & Ruppel, A. (2017). Is the calorie concept a real solution to the obesity epidemic?. Global health action, 10(1), 1289650. https://doi.org/10.1080/16549716.2017.1289650.

Dávila Grisalez, A. A., Mazuera Quiceno, C. A., Carreño Herrera, A. L., & Henao Corrales, J. L. (2021). Effect of a high intensity aerobic interval training program on an overweight or obese female school population. Retos, 39, 453–458. https://doi.org/10.47197/retos.v0i39.78200.

Deemer, S. E., Castleberry, T. J., Irvine, C., Newmire, D. E., Oldham, M., King, G. A., Ben-Ezra, V., Irving, B. A., & Biggerstaff, K. D. (2018). Pilot study: an acute bout of high intensity interval exercise increases 12.5 h GH secretion. Physiological reports, 6(2), e13563. https://doi.org/10.14814/phy2.13563.

Dichtel, L. E., Yuen, K. C., Bredella, M. A., Gerweck, A. V., Russell, B. M., Riccio, A. D., Gurel, M. H., Sluss, P. M., Biller, B. M., & Miller, K. K. (2014). Overweight/Obese adults with pituitary disorders require lower peak growth hormone cutoff values on glucagon stimulation testing to avoid overdiagnosis of growth hormone deficiency. The Journal of clinical endocrinology and metabolism, 99(12), 4712–4719. https://doi.org/10.1210/jc.2014-2830.

Dinas, P. C., Markati, A. S., & Carrillo, A. E. (2014). Exercise-Induced Biological and Psychological Changes in Overweight and Obese Individuals: A Review of Recent Evidence. International Scholarly Research Notices, 2014, Article ID 964627, 11 pages. https://doi.org/10.1155/2014/964627.

Dourida, M., Tzanela, M., Asimakopoulou, A., Botoula, E., Koutsilieris, M., & Philippou, A. (2019). Endocrine responses after a single bout of moderate aerobic exercise in healthy adult humans. Journal of applied biomedicine, 17(1), 46. https://doi.org/10.32725/jab.2018.004.

Gar, C., Rottenkolber, M., Haenelt, M., Potzel, A. L., Kern-Matschilles, S., Then, C., Seissler, J., Bidlingmaier, M., & Lechner, A. (2020). Altered metabolic and hormonal responses to moderate exercise in overweight/obesity. Metabolism: clinical and experimental, 107, 154219. https://doi.org/10.1016/j.metabol.2020.154219.

Greenstein, B., & Wood, D. F., (2011). The Endocrine System at a Glance 3rd Edition, Kindle Edition. Hoboken, New Jersey: Wiley-Blackwell.

Gough, L., Castell, L. M., Gatti, R., & Godfrey, R. J. (2016). Growth Hormone Concentrations in Different Body Fluids Before and After Moderate Exercise. Sports medicine - open, 2(1), 30. https://doi.org/10.1186/s40798-016-0054-z.

Guyton, A. C., & Hall, J. E. (2014). Medical Physiology 12th Edition. Jakarta: EGC Medical Book.

Hejla, D., Dror, N., Pantanowitz, M., Nemet, D., & Eliakim, A. (2022). Reduced Growth Hormone Response to Anaerobic Exercise Among Children With Overweight and Obesity. Journal of strength and conditioning research, 36(8), 2194–2197. https://doi.org/10.1519/JSC.0000000000003798.

Higgins, J.K., & Kleimbaun, A.P. (1985). Design Methodology for Randomized Clinical Trials; Family Health International: Arlington, VA, USA. pp. 24–25.

Høgild, M. L., Gudiksen, A., Pilegaard, H., Stødkilde-Jørgensen, H., Pedersen, S. B., Møller, N., Jørgensen, J. O. L., & Jessen, N. (2019). Redundancy in regulation of lipid accumulation in skeletal muscle during prolonged fasting in obese men. Physiological reports, 7(21), e14285. https://doi.org/10.14814/phy2.14285.

Hruby, A., & Hu, F. B. (2015). The Epidemiology of Obesity: A Big Picture. PharmacoEconomics, 33(7), 673–689. https://doi.org/10.1007/s40273-014-0243-x.

Kraemer, W. J., Ratamess, N. A., & Nindl, B. C. (2017). Recovery responses of testosterone, growth hormone, and IGF-1 after resistance exercise. Journal of applied physiology (Bethesda, Md. : 1985), 122(3), 549–558. https://doi.org/10.1152/japplphysiol.00599.2016.

Mannerkorpi, K., Landin-Wilhelmsen, K., Larsson, A., Cider, Å., Arodell, O., & Bjersing, J. L. (2017). Acute effects of physical exercise on the serum insulin-like growth factor system in women with fibromyalgia. BMC musculoskeletal disorders, 18(1), 37. https://doi.org/10.1186/s12891-017-1402-y.

Misra, M., Bredella, M. A., Tsai, P., Mendes, N., Miller, K. K., & Klibanski, A. (2008). Lower growth hormone and higher cortisol are associated with greater visceral adiposity, intramyocellular lipids, and insulin resistance in overweight girls. American journal of physiology. Endocrinology and metabolism, 295(2), E385–E392. https://doi.org/10.1152/ajpendo.00052.2008.

Olarescu, N. C., Gunawardane, K., Hansen, T. K., Møller, N., & Jørgensen, J. O. L. (2019). Normal Physiology of Growth Hormone in Adults. In K. R. Feingold (Eds.) et. al., Endotext. MDText.com, Inc.

Oliver, S. R., Rosa, J. S., Minh, T. D., Pontello, A. M., Flores, R. L., Barnett, M., & Galassetti, P. R. (2010). Dose-dependent relationship between severity of pediatric obesity and blunting of the growth hormone response to exercise. Journal of applied physiology (Bethesda, Md. : 1985), 108(1), 21–27. https://doi.org/10.1152/japplphysiol.00589.2009.

Pranoto, A., Cahyono, M. B. A., Yakobus, R., Izzatunnisa, N., Ramadhan, R. N., Rejeki, P. S., Miftahussurur, M., Effendi, W. I., Wungu, C. D. K., & Yamaoka, Y. (2023). Long-Term Resistance-Endurance Combined Training Reduces Pro-Inflammatory Cytokines in Young Adult Females with Obesity. Sports (Basel, Switzerland), 11(3), 54. https://doi.org/10.3390/sports11030054.

Pranoto, A., Rejeki, P., Miftahussurur, M., Setiawan, H., Yosika, G., Munir, M., Maesaroh, S., Purwoto, S., Waritsu, C. & Yamaoka, Y. (2023). Single 30 min treadmill exercise session suppresses the production of pro-inflammatory cytokines and oxidative stress in obese female adolescents. Journal of Basic and Clinical Physiology and Pharmacology, 34(2), 235-242. https://doi.org/10.1515/jbcpp-2022-0196.

Rejeki, P. S., Pranoto, A., Rahmanto, I., Izzatunnisa, N., Yosika, G. F., Hernaningsih, Y., Wungu, C. D. K., & Halim, S. (2023). The Positive Effect of Four-Week Combined Aerobic-Resistance Training on Body Composition and Adipokine Levels in Obese Females. Sports (Basel, Switzerland), 11(4), 90. https://doi.org/10.3390/sports11040090.

Romieu, I., Dossus, L., Barquera, S., Blottière, H. M., Franks, P. W., Gunter, M., Hwalla, N., Hursting, S. D., Leitzmann, M., Margetts, B., Nishida, C., Potischman, N., Seidell, J., Stepien, M., Wang, Y., Westerterp, K., Winichagoon, P., Wiseman, M., Willett, W. C., & IARC working group on Energy Balance and Obesity (2017). Energy balance and obesity: what are the main drivers?. Cancer causes & control : CCC, 28(3), 247–258. https://doi.org/10.1007/s10552-017-0869-z.

Sabag, A., Chang, D., & Johnson, N. A. (2021). Growth Hormone as a Potential Mediator of Aerobic Exercise-Induced Reductions in Visceral Adipose Tissue. Frontiers in physiology, 12, 623570. https://doi.org/10.3389/fphys.2021.623570.

Santos, V. O. A., Browne, R. A. V., Souza, D. C., Matos, V. A. F., Macêdo, G. A. D., Farias-Junior, L. F., Farias-Júnior, J. C., Costa, E. C., & Fayh, A. P. T. (2019). Effects of High-Intensity Interval and Moderate-Intensity Continuous Exercise on Physical Activity and Sedentary Behavior Levels in Inactive Obese Males: A Crossover Trial. Journal of sports science & medicine, 18(3), 390–398.

Sasaki, H., Morishima, T., Hasegawa, Y., Mori, A., Ijichi, T., Kurihara, T., & Goto, K. (2014). 4 weeks of high-intensity interval training does not alter the exercise-induced growth hormone response in sedentary men. SpringerPlus, 3, 336. https://doi.org/10.1186/2193-1801-3-336.

Sauro, L. M., & Kanaley, J. A. (2003). The effect of exercise duration and mode on the growth hormone responses in young women on oral contraceptives. European journal of applied physiology, 90(1-2), 69–75. https://doi.org/10.1007/s00421-003-0863-x.

Savastano, S., Di Somma, C., Barrea, L., & Colao, A. (2014). The complex relationship between obesity and the somatropic axis: the long and winding road. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 24(6), 221–226. https://doi.org/10.1016/j.ghir.2014.09.002.

Solis-Urra, P., Fernández-Cueto, N., Nanjarí, R., Huber-Pérez, T., Cid-Arnes, M. P., Zurita-Corvalán, N., Rodriguez-Rodriguez, F., & Cristi-Montero, C. (2019). A mejor condición física mejores resultados de una ley contra la obesidad (Better fitness, better results of a law against obesity). Retos, 36, 17–21. https://doi.org/10.47197/retos.v36i36.66782.

Stanley, T. L., & Grinspoon, S. K. (2015). Effects of growth hormone-releasing hormone on visceral fat, metabolic, and cardiovascular indices in human studies. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 25(2), 59–65. https://doi.org/10.1016/j.ghir.2014.12.005.

Strasser B. (2013). Physical activity in obesity and metabolic syndrome. Annals of the New York Academy of Sciences, 1281(1), 141–159. https://doi.org/10.1111/j.1749-6632.2012.06785.x.

Sugiharto, Merawati, D., Pranoto, A., & Susanto, H. (2022). Physiological response of endurance exercise as a growth hormone mediator in adolescent women's. Journal of basic and clinical physiology and pharmacology, 34(1), 61–67. https://doi.org/10.1515/jbcpp-2022-0060.

Susanto, H., Sugiharto, Taufiq, A., Pranoto, A., & Purnomo, J. D. T. (2023). Dynamic alteration of plasma levels of betatrophin in younger female onset obesity post acute moderate-intensity exercise training. Saudi journal of biological sciences, 30(2), 103546. https://doi.org/10.1016/j.sjbs.2022.103546.

Wang, X., Wang, S., Wu, H., Jiang, M., Xue, H., Zhu, Y., Wang, C., Zha, X., & Wen, Y. (2020). Human growth hormone level decreased in women aged <60 years but increased in men aged >50 years. Medicine, 99(2), e18440. https://doi.org/10.1097/MD.0000000000018440.

Wood, C. J., Clow, A., Hucklebridge, F., Law, R., & Smyth, N. (2018). Physical fitness and prior physical activity are both associated with less cortisol secretion during psychosocial stress. Anxiety, stress, and coping, 31(2), 135–145. https://doi.org/10.1080/10615806.2017.1390083.

Downloads

Publicado

2024-01-01

Como Citar

Pranoto, A., Rejeki, P. S., Miftahussurur, M., Yosika, G. F., Ihsan, M., Herawati, L., Rahmanto, I., & Halim, S. (2024). O exercício aeróbico aumenta a liberação do hormônio do crescimento na circulação sanguínea em mulheres obesas. Retos, 51, 726–731. https://doi.org/10.47197/retos.v51.99944

Edição

Secção

Artigos de caráter científico: trabalhos de pesquisas básicas e/ou aplicadas.

Artigos mais lidos do(s) mesmo(s) autor(es)

<< < 1 2