Adult hepatoblastoma. A case report

Authors

  • A. Goikoetxea Urdiain Complejo Hospitalario de Navarra. Pamplona
  • P. Sánchez Acedo
  • J. Mateo Retuerta
  • A. Tarifa Castilla
  • C. Zazpe Ripa
  • J. Herrera Cabezón

DOI:

https://doi.org/10.23938/ASSN.0264

Keywords:

Hepatoblastoma. Primary hepatic tumours. Adult.

Abstract

Adult hepatoblastoma is a rare pathology. Its pathogeny is not well understood and prognosis is very bad. We present a case of adult hepatoblastoma treated in our centre.

A 65 year-old male, without previous hepatopathy, who consulted due to right hypochondrial pain with a subacute evolution. The pathological diagnosis was adult epithelial hepatoblastoma, with free surgical margins. The patient received a second surgical intervention 5 months later due to early recurrence and died 10 months after the diagnosis due to a new massive recurrence. His definitive diagnosis is histological. Radical surgery is the only treatment that increases survival, but recurrence is frequent. There are no well-defined patterns of adjuvant chemotherapy nor is there any transplant experience.

Downloads

Download data is not yet available.

Author Biography

A. Goikoetxea Urdiain, Complejo Hospitalario de Navarra. Pamplona

Médico Interno Residente de 3º de Cirugía General y Digestiva.

References

1. AL-SINANI S, AL-NAAMANI K. Adult hepatoblastoma: What do we know? Sultan Qaboos Univ Med J 2015; 15:e 155-156.

https://doi.org/10.18295/2075-0528.1675

2. CIENFUEGOS JA, LABIANO T, PEDANO N, ZOZAYA GN, MARTÍ-CRUCHAGA P, PANIZO Á et al. Adult hepatoblastoma. Rev Esp Enferm Dig 2013; 105: 229-231.

https://doi.org/10.4321/S1130-01082013000400009

3. ZHANG Q, MING J, ZHANG S, GUO D, QIU X. A rare case of adult hepatoblastoma with neuroendocrine differentiation misdiagnosed as neuroendocrine tumor. Int J Clin Exp Pathol 2013; 6: 308-313.

4. AL-JIFFRY BO. Adult hepatoblastoma: A case report and literature review. Int J Surg Case Rep 2013; 4: 204-207.

https://doi.org/10.1016/j.ijscr.2012.10.019

5. ROUGEMONT AL, MCLIN VA, TOSO C, WILDHABER BE. Adult hepatoblastoma: Learning from children. J Hepatol 2012; 56: 1392-1403. doi: 10.1016/j.jhep.2011.10.028.

https://doi.org/10.1016/j.jhep.2011.10.028

6. ZHENG MH, ZHANG L, GU DN, SHI HQ, ZENG QQ, CHEN YP. Hepatoblastoma in adult: Review of the literature. J Clin Med Res 2009; 1: 13-16. doi: 10.4021/jocmr2009.01.1222.

https://doi.org/10.4021/jocmr2009.01.1222

7. WANG LL, FILIPPI RZ, ZURAKOWSKI D, ARCHIBALD T, VARGAS SO, VOSS SD, et al. Effects of neoadjuvant chemotherapy on hepatoblastoma: A morphologic and immunohistochemical study. Am J Surg Pathol. 2010; 34: 287-299. doi: 10.1097/PAS.0b013e3181ce5f1e.

https://doi.org/10.1097/PAS.0b013e3181ce5f1e

8. BASILE J, CALDWELL S, NOLAN N, HAMMERLE C. Clear cell hepatocellular carcinoma arising 25 years after the successful treatment of an infantile hepatoblastoma. Ann Hepatol 2010; 9: 465-467.

https://doi.org/10.1016/S1665-2681(19)31625-4

9. MASUDA T, BEPPU T, HORINO K, KOMORI H, HAYASHI H, OKABE H et al. Occurrence of hepatocellular carcinoma after hepatoblastoma resection in an adult with hepatitis C virus. Hepatol Res 2009; 39: 525-530. doi: 10.1111/j.1872-034X.2008.00471.x.

https://doi.org/10.1111/j.1872-034X.2008.00471.x

10. WANG YX, LIU H. Adult hepatoblastoma: systemic review of the English literature. Dig Surg 2012; 29: 323-330. doi: 10.1159/000342910.

https://doi.org/10.1159/000342910

11. LUO JH, REN B, KERYANOV S, TSENG GC, RAO UN, MONGA SP et al. Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas. Hepatology 2006; 44: 1012-1024. doi: 10.1002/hep.21328

https://doi.org/10.1002/hep.21328

12. MOON SB, SHIN HB, SEO JM, LEE SK. Hepatoblastoma: 15-year experience and role of surgical treatment. J Korean Surg Soc 2011; 81: 134-140. doi: 10.4174/jkss.2011.81.2.134.

https://doi.org/10.4174/jkss.2011.81.2.134

13. ZSÍROS J, MAIBACH R, SHAFFORD E, BRUGIERES L, BROCK P, CZAUDERNA P et al. Successful treatment of childhood high-risk hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: Final results of the SIOPEL-3HR study. J Clin Oncol 2010; 28: 2584-2590. doi: 10.1200/JCO.2009.22.4857.

https://doi.org/10.1200/JCO.2009.22.4857

14. PIMPALWAR AP, SHARIF K, RAMANI P, STEVENS M, GRUNDY R, MORLAND B et al. Strategy for hepatoblastoma management: Transplant versus nontransplant surgery. J Pediatr Surg 2002; 37: 240-245. doi: 10.1053/jpsu.2002.30264.

https://doi.org/10.1053/jpsu.2002.30264

15. OTTE JB, PRITCHARD J, ARONSON DC, BROWN J, CZAUDERNA P, MAIBACH R et al. Liver transplantation for hepatoblastoma: Results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience. Pediatr Blood Cancer 2004; 42: 74-83. doi: 10.1002/pbc.10376.

https://doi.org/10.1002/pbc.10376

Published

2016-08-31

How to Cite

1.
Goikoetxea Urdiain A, Sánchez Acedo P, Mateo Retuerta J, Tarifa Castilla A, Zazpe Ripa C, Herrera Cabezón J. Adult hepatoblastoma. A case report. An Sist Sanit Navar [Internet]. 2016 Aug. 31 [cited 2025 Dec. 15];39(2):301-4. Available from: https://recyt.fecyt.es/index.php/ASSN/article/view/38879

Issue

Section

Clinical notes

Most read articles by the same author(s)

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.