Potencial de la curcumina para reducir los niveles séricos del factor nuclear kappa B (NF-kB) después del ejercicio de alta intensidad (Potential of Curcumin to Reduce Serum Nuclear Factor-Kappa B (NF-kB) Levels After High-Intensity Exercise)
DOI:
https://doi.org/10.47197/retos.v57.103902Palabras clave:
Curcumin, Inflammation, Cytokines, ExerciseResumen
El estudio tuvo como objetivo analizar el efecto de la curcumina sobre los niveles séricos de NF-kB después del ejercicio de alta intensidad. Esta investigación experimental utiliza un diseño de grupo de control pre y post. Los sujetos de investigación fueron seleccionados mediante una técnica de muestreo intencional. A continuación, los sujetos se dividieron en dos grupos: el grupo K1 con un placebo y el grupo K2 con una dosis de 400 mg de curcumina. En este estudio participaron un total de 20 hombres sanos de entre 20 y 30 años. El primer día se recogieron datos sobre las características de los sujetos de la investigación. Los sujetos calentaron y realizaron entrenamiento de alta intensidad en ejercicios de equipo y prensas de piernas con una intensidad del 80-90% de la capacidad máxima. La intensidad de cada sujeto de investigación se determinó mediante la prueba de una repetición máxima (1RM). 1RM es el peso máximo que se puede levantar en una repetición de un movimiento. El ejercicio se realiza en cuatro series de 10 repeticiones con un tiempo de recuperación de aproximadamente 60 segundos entre series. El segundo día, 24 horas después del ejercicio de alta intensidad, a todos los sujetos se les tomaron muestras de sangre (prueba previa) y luego se les administró una intervención basada en sus respectivos grupos. Al tercer día, 48 horas después del ejercicio de alta intensidad, a todos los sujetos se les tomaron muestras de sangre (post-test). Las muestras de sangre se analizaron en el laboratorio mediante el método ELISA con números de catálogo Human NF-kB ELISA kit E0690Hu. Los resultados de este estudio informaron que el grupo que recibió curcumina después de un ejercicio de alta intensidad redujo significativamente los niveles séricos de NF-kB (*p<0,05) en comparación con el grupo de placebo. Se puede concluir que la administración de curcumina a 400 mg después del ejercicio de alta intensidad puede reducir los niveles séricos de NF-kB. Se cree que la reducción de los niveles de NF-kB disminuye las citoquinas proinflamatorias como el TNF-a y está estrechamente relacionado con el dolor muscular después del ejercicio. Recomendamos utilizar curcumina como ingrediente natural que potencialmente puede reducir el NF-kB. En futuras investigaciones, recomendamos encarecidamente examinar otros biomarcadores inflamatorios, como el TNF-a y la interleucina.
Palabras clave: Curcumina, Inflamación, Citoquinas, Ejercicio, Salud
Abstract. The study aimed to analyze the effect of curcumin on serum NF-kB levels after high-intensity exercise. This experimental research uses a pre and post-control group design. Research subjects were selected using a purposive sampling technique. Following this, the subjects were divided into two groups: Group K1 with a placebo and Group K2 with a dose of 400 mg of curcumin. A total of 20 healthy men aged between 20-30 years participated in this study. On the first day, Data on the characteristics of the research subjects were collected. The subjects warmed up and did high-intensity training in squad exercises and leg presses with an intensity of 80-90% of maximum ability. The intensity of each research subject was determined using the one repetition maximum (1RM) test. 1RM is the maximum weight that can be lifted in one repetition of a movement. The exercise is performed in four sets of 10 repetitions with a recovery time of approximately 60 seconds between set. On the second day, 24 hours after high-intensity exercise, all subjects took blood samples (pre-test) and then were given intervention based on their respective groups. On the third day, 48 hours after high-intensity exercise, all subjects took blood samples (post-test). Blood samples were analyzed in the laboratory using the ELISA method with catalog numbers Human NF-kB ELISA kit E0690Hu. The results of this study reported that the group given curcumin after high-intensity exercise reduced serum NF-kB levels significantly (*p<0.05) compared to the placebo group. It can be concluded that the administration of curcumin at 400 mg after high-intensity exercise can reduce serum NF-kB levels. Reducing NF-kB levels is believed to lessen pro-inflammatory cytokines such as TNF-a and is closely related to muscle pain after exercise. We recommend using curcumin as a natural ingredient that can potentially reduce NF-kB. In future research, we strongly recommend examining other inflammatory biomarkers, such as TNF-a and Interleukin.
Keywords: Curcumin, Inflammation, Cytokines, Exercise, Health
Citas
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