Los ácidos grasos poliinsaturados n-3 (PUFA) y el ejercicio físico tienen el potencial de reducir la intensi-dad del dolor en mujeres con dismenorrea primaria: Systematic Review (N-3 polyunsaturated fatty acids (PUFAs) and physical exercise have the potential to reduce pain intensity in women with primary dysmenorrhea: Systematic Review )

Autores/as

  • Sri Gusti Handayani Universitas Negeri Padang, Indonesia
  • Novadri Ayubi Universitas Negeri Surabaya
  • Anton Komaini Universitas Negeri Padang https://orcid.org/0000-0002-2955-0175
  • Heru Syarli Lesmana Universität Innsbruck
  • Nining Widyah Kusnanik Universitas Negeri Surabaya https://orcid.org/0000-0002-0734-6843
  • Lilik Herawati Universitas Airlangga
  • Muchamad Arif Al Ardha Universitas Negeri Surabaya https://orcid.org/0000-0002-9192-2072
  • Nurhasan Nurhasan Universitas Negeri Surabaya
  • Fatkur Rohman Kafrawi Universitas Negeri Surabaya
  • Dhea Regita Sastika Putri Universitas Airlangga https://orcid.org/0000-0001-8646-9851
  • Donny Ardi Kusuma Universitas Negeri Surabaya, Indonesia
  • Ardo Yulpiko Putra Universitas Pasir Pangaraian

DOI:

https://doi.org/10.47197/retos.v48.96629

Palabras clave:

AGPI N-3, Ejercicio físico, Cartilla Dismenore, Dolor menstrual

Resumen

Esta revisión tiene como objetivo resaltar el potencial de los n-3 PUFAs y el ejercicio físico para reducir la intensidad del dolor en mujeres con dismenorrea primaria. Este tipo de investigación es una systematic review que utiliza estrategias integrales, como la búsqueda de artículos en bases de datos de revistas de investigación. Las bases de datos utilizadas son Pubmed/MEDLINE, Scopus, Web of Science y Embase. Las poblaciones analizadas en este trabajo son: el potencial de los n-3 PUFAs y el ejercicio físico para reducir la dismenorrea primaria. Los criterios de inclusión en este estudio fueron revistas que hablaran sobre los n-3 PUFAs, el ejercicio, la dismenorrea primaria y el dolor menstrual. Los criterios de exclusión en este estudio fueron revistas internacionales de mala reputación. Para la operatividad estándar, este estudio sigue los elementos de informe preferidos para revisiones sistemáticas y metanálisis (PRISMA). Esta revisión explica que los n-3 PUFAs administrados en la dosis correcta, alrededor de 1000 mg/día, tienen el potencial de reducir la intensidad del dolor al suprimir la producción de citoquinas proinflamatorias y eicosanoides. Además, los n-3 PUFAs tienen el potencial de prevenir y reducir la intensidad del dolor al inhibir la síntesis de prostaglandinas. La progesterona es muy importante en mujeres con dismenorrea primaria para controlar la secreción de prostaglandinas. Esta revisión explica que el ejercicio regular de intensidad baja a moderada (30-75% de la capacidad máxima) realizado 3 veces en 1 semana puede aumentar las concentraciones de progesterona. Los ejercicios físicos que se pueden hacer para reducir la intensidad del dolor debido a la dismenorrea primaria incluyen ejercicios de estiramiento, trote y ejercicios de yoga.

Palabras clave: N-3- PUFAs; Ejercicio físico; Dismenorrea primaria; Dolor menstrual

Abstract. This review aims to highlight the potential of n-3 PUFAs and physical exercise in reducing pain intensity in women with primary dysmenorrhea. This type of research is a systematic review using comprehensive strategies such as searching for articles in research journal databases. The databases used are Pubmed/MEDLINE, Scopus, Web of Science, and Embase. The populations analyzed in this paper are: the potential of n-3 PUFAs and physical exercise to reduce primary dysmenorrhea. The inclusion criteria in this study were journals that discussed n-3 PUFAs, exercise, primary dysmenorrhea, and menstrual pain. The exclusion criteria in this study were disreputable international journals. For standard operationalization, This study follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). This review explains that N-3 PUFAs given at the right dose, around 1000 mg/day have the potential to reduce pain intensity by suppressing the production of pro-inflammatory cytokines and eicosanoids. In addition, N-3 PUFAs have the potential to prevent and reduce pain intensity by inhibiting prostaglandin synthesis. Progesterone is very important in women with primary dysmenorrhea in order to control prostaglandin secretion. This review explains that regular exercise with low to moderate intensity (30-75% of maximum ability) performed 3 times in 1 week can increase progesterone concentrations. Physical exercises that can be done to reduce pain intensity due to primary dysmenorrhea include stretching exercises, jogging, and yoga exercises.

Keywords: N-3 PUFAs, Physical Exercise; Dismenore Primer; Menstrual Pain

 

Citas

Abreu-Sánchez, Ana, María Laura Parra-Fernández, María Dolores Onieva-Zafra, Juan Diego Ramos-Pichardo, and Elia Fernández-Martínez. Type of Dysmenorrhea, Menstrual Characteristics and Symptoms in Nursing Students in Southern Spain. Healthcare (Basel, Switzerland) (2020). 8 (3), 302. https://doi.org/10.3390/healthcare8030302.

Amjad Khan, Waleed, Hu Chun-Mei, Nadeem Khan, Amjad Iqbal, Shan-Wu Lyu, and Farooq Shah. Bioengineered Plants Can Be a Useful Source of Omega-3 Fatty Acids. BioMed Research International (2017). 2017(7348919), 1-9. https://doi.org/10.1155/2017/7348919.

Ayubi, N, E Yuniarti, N W Kusnanik, L Herawati, P M Indika, R Y Putra, and A Komaini. 2022. Acute Effects of N-3 Polyunsaturated Fatty Acids ( PUFAs ) Reducing Tumor Necrosis Factor-Alpha ( TNF- a ) Levels and Not Lowering Malondialdehyde ( MDA ) Levels after Anaerobic Exercise. Journal of Biological Regulators and Homeostatic Agents (2022). 36(1), 7-11. https://doi.org/10.23812/21-468-A.

Ayubi, Novadri, Purwanto Bambang, Purwo Sri Rejeki, Nining Widyah Kusnanik, and Lilik Herawati. Effect of Acute Omega 3 Supplementation Reduces Serum Tumor Necrosis Factor-Alpha (TNF-a) Levels, Pain Intensity, and Maintains Muscle Strength after High-Intensity Weight Training. Retos (2022). 46, 677–682. https://doi.org/10.47197/retos.v46.93720.

Azeez, Juberiya M, Thachapillil Ramakrishnan Susmi, Viji Remadevi, Vini Ravindran, Anjana Sasikumar Sujatha, Raveendran Nair Sobha Ayswarya, and Sreeharshan Sreeja. New Insights into the Functions of Progesterone Receptor (PR) Isoforms and Progesterone Signaling. American Journal of Cancer Research (2021). 11(11), 5214–5232. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640821/.

Barcikowska, Zofia, Magdalena E Grzybowska, Piotr Wąż, Marta Jaskulak, Monika Kurpas, Maksymilian Sotomski, Małgorzata Starzec-Proserpio, Elżbieta Rajkowska-Labon, Rita Hansdorfer-Korzon, and Katarzyna Zorena. 2022. Effect of Manual Therapy Compared to Ibuprofen on Primary Dysmenorrhea in Young Women—Concentration Assessment of C-Reactive Protein, Vascular Endothelial Growth Factor, Prostaglandins and Sex Hormones. Journal of Clinical Medicine (2022). 11(10), 2686. https://doi.org/10.3390/jcm11102686.

Barcikowska, Zofia, Elżbieta Rajkowska-Labon, Magdalena Emilia Grzybowska, Rita Hansdorfer-Korzon, and Katarzyna Zorena. “Inflammatory Markers in Dysmenorrhea and Therapeutic Options.” International Journal of Environmental Research and Public Health (2020). 17(4), 1191. https://doi.org/10.3390/ijerph17041191.

Bernardi, Mariagiulia, Lucia Lazzeri, Federica Perelli, Fernando M Reis, and Felice Petraglia. Dysmenorrhea and Related Disorders. F1000Research (2017). 6(1), 1645. https://doi.org/10.12688/f1000research.11682.1.

Cui, Luying, Xinyu Shao, Wenye Sun, Fangling Zheng, Junsheng Dong, Jun Li, Heng Wang, and Jianji Li. Anti-Inflammatory Effects of Progesterone through NF-ΚB and MAPK Pathway in Lipopolysaccharide- or Escherichia Coli-Stimulated Bovine Endometrial Stromal Cells. PLOS ONE (2022). 17 (4), 0266144. https://doi.org/10.1371/journal.pone.0266144.

Demirturk, Fazli, Tayfun Gungor, Funda Demirturk, Turkan Akbayrak, and E Munire Aker. Relief of Primary Dysmenorrhea by Supplementation with Omega-3 Fatty Acids. The Pain Clinic (2002). 14 (1), 81–84. https://doi.org/10.1163/156856902760189223.

Duman, Nuriye Büyükkayaci, Fatma Yıldırım, and Gülşen Vural. Risk Factors for Primary Dysmenorrhea and the Effect of Complementary and Alternative Treatment Methods: Sample from Corum, Turkey. International Journal of Health Sciences (2022). 16(3), 35–43. https://pubmed.ncbi.nlm.nih.gov/35599944/

Écochard, René, René Leiva, Thomas Bouchard, Hans Boehringer, Jean Iwaz, and Ingrid Plotton. Descriptive Analysis of the Relationship between Progesterone and Basal Body Temperature across the Menstrual Cycle. Steroids (2022). 178(2), 108964. https://doi.org/10.1016/j.steroids.2022.108964.

Fernández-Martínez, Elia, María Dolores Onieva-Zafra, and María Laura Parra-Fernández. The Impact of Dysmenorrhea on Quality of Life Among Spanish Female University Students. International Journal of Environmental Research and Public Health (2019). (16)5, 713. https://doi.org/10.3390/ijerph16050713.

Gammone, Maria Alessandra, Graziano Riccioni, Gaspare Parrinello, and Nicolantonio D’Orazio. Omega-3 Polyunsaturated Fatty Acids: Benefits and Endpoints in Sport. Nutrients (2018). 11(1), 46. https://doi.org/10.3390/nu11010046.

Granda, Dominika, Maria Karolina Szmidt, and Joanna Kaluza. Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case-Control and Cross-Sectional Studies. Antioxidants (Basel, Switzerland) (2021). 10(4), 604. https://doi.org/10.3390/antiox10040604.

Hong, Fang, Guiyan He, Manqi Zhang, Boyang Yu, and Chengzhi Chai. “The Establishment of a Mouse Model of Recurrent Primary Dysmenorrhea.” International Journal of Molecular Sciences (2022). 23(11), 6128. https://doi.org/10.3390/ijms23116128.

Huynh, Minh Dieu, and David D Kitts. Evaluating Nutritional Quality of Pacific Fish Species from Fatty Acid Signatures. Food Chemistry (2009). 114 (3), 912–18. https://doi.org/https://doi.org/10.1016/j.foodchem.2008.10.038.

Innes, Jacqueline K, and Philip C Calder. Marine Omega-3 (N-3) Fatty Acids for Cardiovascular Health: An Update for 2020.” International Journal of Molecular Sciences (2020). 21(4), 1362. https://doi.org/10.3390/ijms21041362.

Itani, Rania, Lama Soubra, Samar Karout, Deema Rahme, Lina Karout, and Hani M J Khojah. Primary Dysmenorrhea: Pathophysiology, Diagnosis, and Treatment Updates. Korean Journal of Family Medicine (2022). 43(2), 101–8. https://doi.org/10.4082/kjfm.21.0103.

Jaleel, Ghufran, Muhammad Abu Shaphe, Abdur Raheem Khan, Deepak Malhotra, Huma Khan, Sana Parveen, Mohammed Qasheesh, et al. Effect of Exercises on Central and Endocrine System for Pain Modulation in Primary Dysmenorrhea.” Journal of Lifestyle Medicine (2022). 12(1), 15–25. https://doi.org/10.15280/jlm.2022.12.1.15.

Kannan, Priya, Cathy M Chapple, Dawn Miller, Leica Claydon-Mueller, and G David Baxter. Effectiveness of a Treadmill-Based Aerobic Exercise Intervention on Pain, Daily Functioning, and Quality of Life in Women with Primary Dysmenorrhea: A Randomized Controlled Trial. Contemporary Clinical Trials ( 2019). 81(7), 80–86. https://doi.org/10.1016/j.cct.2019.05.004.

Kannan, Priya, Kwok-Kuen Cheung, and Benson Wui-Man Lau. Does Aerobic Exercise Induced-Analgesia Occur through Hormone and Inflammatory Cytokine-Mediated Mechanisms in Primary Dysmenorrhea? Medical Hypotheses (2019). 123(2), 50–54. https://doi.org/10.1016/j.mehy.2018.12.011.

Kim, Sang-Dol. Yoga for Menstrual Pain in Primary Dysmenorrhea: A Meta-Analysis of Randomized Controlled Trials. Complementary Therapies in Clinical Practice (2019). 36 (8)), 94–99. https://doi.org/10.1016/j.ctcp.2019.06.006.

Kitson, Alex P, Ashley C Patterson, Hamid Izadi, and Ken D Stark. Pan-Frying Salmon in an Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) Enriched Margarine Prevents EPA and DHA Loss. Food Chemistry (2009). 114 (3): 927–32. https://doi.org/https://doi.org/10.1016/j.foodchem.2008.10.039.

Kırıcı, Pınar, and Elif Seren Tanrıverdi. Effects of Different Progesterone Doses on the Concentrations of Proinflammatory and Anti-Inflammatory Cytokines in Pregnant Women With Threatened Abortion. Cureus (2021). 13(11), 19333. https://doi.org/10.7759/cureus.19333.

Komprda, Tomas, Zbysek Sladek, Zuzana Sevcikova, Veronika Svehlova, Jan Wijacki, Roman Guran, Tomas Do, et al. 2020. “Comparison of Dietary Oils with Different Polyunsaturated Fatty Acid N-3 and n-6 Content in the Rat Model of Cutaneous Wound Healing.” International Journal of Molecular Sciences (2020). 21(21), 7911. https://doi.org/10.3390/ijms21217911.

Kris-Etherton, P M, D S Taylor, S Yu-Poth, P Huth, K Moriarty, V Fishell, R L Hargrove, G Zhao, and T D Etherton. Polyunsaturated Fatty Acids in the Food Chain in the United States. The American Journal of Clinical Nutrition (2000). 71(1 Suppl): 179-188. https://doi.org/10.1093/ajcn/71.1.179S.

Leimert, Kelycia B, Barbara S E Verstraeten, Angela Messer, Rojin Nemati, Kayla Blackadar, Xin Fang, Sarah A Robertson, Sylvain Chemtob, and David M Olson. Cooperative Effects of Sequential PGF2α and IL-1β on IL-6 and COX-2 Expression in Human Myometrial Cells†. Biology of Reproduction (2019). 100(5), 1370–1385. https://doi.org/10.1093/biolre/ioz029.

Li, Qiu-Yue, Hai-Yu Xu, and Hong-Jun Yang. [Effect of proinflammatory factors TNF-α,IL-1β, IL-6 on neuropathic pain]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2017). 42(19), 3709–12. https://doi.org/10.19540/j.cnki.cjcmm.20170907.004.

Loukas, Vassilis, Christos Dimizas, Vassilia J Sinanoglou, and Sofia Miniadis-Meimaroglou. EPA, DHA, Cholesterol and Phospholipid Content in Pagrus Pagrus (Cultured and Wild), Trachinus Draco and Trigla Lyra from Mediterranean Sea. Chemistry and Physics of Lipids (2010). 163(3), 292–99. https://doi.org/10.1016/j.chemphyslip.2010.01.004.

Mahesh, Gopa, Kotha Anil Kumar, and Pallu Reddanna. Overview on the Discovery and Development of Anti-Inflammatory Drugs: Should the Focus Be on Synthesis or Degradation of PGE(2)? Journal of Inflammation Research (2021). 21(40), 253–63. https://doi.org/10.2147/JIR.S278514.

Maybin, Jacqueline A, and Hilary O D Critchley. Progesterone: A Pivotal Hormone at Menstruation. Annals of the New York Academy of Sciences (2011), 1221 (3), 88–97. https://doi.org/10.1111/j.1749-6632.2011.05953.x.

Mehrpooya, Maryam, Azadeh Eshraghi, Soghra Rabiee, Amir Larki-Harchegani, and Sara Ataei. Comparison the Effect of Fish-Oil and Calcium Supplementation on Treatment of Primary Dysmenorrhea. Reviews on Recent Clinical Trials (2017). 12(3), 148–53. https://doi.org/10.2174/1574887112666170328125529.

Meng, Fanxing, Jiayi Qiu, Houjie Chen, Xiaojun Shi, Meifang Yin, Meishu Zhu, and Guang Yang. Dietary Supplementation with N-3 Polyunsaturated Fatty Acid-Enriched Fish Oil Promotes Wound Healing after Ultraviolet B-Induced Sunburn in Mice. Food Science & Nutrition (2021). 9(7), 3693–3700. https://doi.org/10.1002/fsn3.2330.

Molla, Alemayehu, Bereket Duko, Bekahegn Girma, Derebe Madoro, Jemberu Nigussie, Zelalem Belayneh, Nebiyu Mengistu, and Birhanie Mekuriaw. Prevalence of Dysmenorrhea and Associated Factors among Students in Ethiopia: A Systematic Review and Meta-Analysis.”Women’s Health (London, England) (2022). 18(1). https://doi.org/10.1177/17455057221079443.

Motahari-Tabari, Narges, Marjan Ahmad Shirvani, and Abbas Alipour. Comparison of the Effect of Stretching Exercises and Mefenamic Acid on the Reduction of Pain and Menstruation Characteristics in Primary Dysmenorrhea: A Randomized Clinical Trial. Oman Medical Journal (2017). 32(1) 7–53. https://doi.org/10.5001/omj.2017.09.

Nie, Wenbo, Ping Xu, Chunyan Hao, Yingying Chen, Yanling Yin, and Lisheng Wang. Efficacy and Safety of Over-the-Counter Analgesics for Primary Dysmenorrhea: A Network Meta-Analysis. Medicine (2020). 99(19), 19881. https://doi.org/10.1097/MD.0000000000019881.

Nursyifa Fadiyah, Nanda, Ginna Megawati, and Dimas Erlangga Luftimas. Potential of Omega 3 Supplementation for Coronavirus Disease 2019 (COVID-19): A Scoping Review.” International Journal of General Medicine (2022). 15(1), 3915–22. https://doi.org/10.2147/IJGM.S357460.

Oladosu, Folabomi A, Frank F Tu, and Kevin M Hellman. 2018. “Nonsteroidal Antiinflammatory Drug Resistance in Dysmenorrhea: Epidemiology, Causes, and Treatment.” American Journal of Obstetrics and Gynecology (2018). 218(4), 390–400. https://doi.org/10.1016/j.ajog.2017.08.108.

Oppedisano, Francesca, Roberta Macrì, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Jessica Maiuolo, Francesca Bosco, et al. The Anti-Inflammatory and Antioxidant Properties of n-3 PUFAs: Their Role in Cardiovascular Protection. Biomedicines (2020). 8(9), 306. https://doi.org/10.3390/biomedicines8090306.

Park, Jinhun, Yu-Cheol Lim, Deok-Sang Hwang, In-Hyuk Ha, and Ye-Seul Lee. Analysis of Healthcare Utilization for Primary Dysmenorrhea in Korea: A Retrospective, Cross-Sectional Study. International Journal of Women’s Health (2022). 14(4) 1015–1027. https://doi.org/10.2147/IJWH.S366386.

Park, Yongsoon. Dietary Reference Intake of N-3 Polyunsaturated Fatty Acids for Koreans. Nutrition Research and Practice (2022). 16 (Suppl 1), 47–56. https://doi.org/10.4162/nrp.2022.16.S1.S47.

Rasmussen, Eva Rye, Pär Hallberg, Ekaterina V Baranova, Niclas Eriksson, Malgorzata Karawajczyk, Caroline Johansson, Marco Cavalli, et al. Genome-Wide Association Study of Angioedema Induced by Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Treatment. The Pharmacogenomics Journal (2020). 20(6), 70–83. https://doi.org/10.1038/s41397-020-0165-2.

Rocha-Rodrigues, Sílvia, Mónica Sousa, Patrícia Lourenço Reis, César Leão, Beatriz Cardoso-Marinho, Marta Massada, and José Afonso. Bidirectional Interactions between the Menstrual Cycle, Exercise Training, and Macronutrient Intake in Women: A Review. Nutrients (2021). 13(2) 438. https://doi.org/10.3390/nu13020438.

Rodriguez-Leyva, Delfin, Chantal M C Dupasquier, Richelle McCullough, and Grant N Pierce. The Cardiovascular Effects of Flaxseed and Its Omega-3 Fatty Acid, Alpha-Linolenic Acid. The Canadian Journal of Cardiology (2010). 26(9), 489–96. https://doi.org/10.1016/s0828-282x(10)70455-4.

Romero-Morales, Carlos, Mónica de la Cueva-Reguera, Beatriz Miñambres-Vallejo, Beatriz Ruiz-Ruiz, César Calvo-Lobo, Israel Casado-Hernández, Daniel López-López, and Vanesa Abuín-Porras. Ultrasound Assessment of the Abdominal Wall Muscles in Women with and without Primary Dysmenorrhea: A Cross-Sectional Study. Diagnostics (2020). 110(3), 166. https://doi.org/10.3390/diagnostics10030166.

Romero-Parra, Nuria, Laura Barba-Moreno, Beatriz Rael, Víctor M Alfaro-Magallanes, Rocío Cupeiro, Ángel E Díaz, Francisco J Calderón, and Ana B Peinado. Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise. International Journal of Environmental Research and Public Health (2020). 17(5), 1618. https://doi.org/10.3390/ijerph17051618.

Sachs, B, T Meier, M M Nöthen, C Stieber, and J Stingl. [Drug-induced angioedema : Focus on bradykinin]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (2018). 69(4), 298–305. https://doi.org/10.1007/s00105-017-4119-9.

Sadeghi, Narges, Farnoush Paknezhad, Mohamadreza Rashidi Nooshabadi, Maria Kavianpour, Sima Jafari Rad, and Hossein Khadem Haghighian. Vitamin E and Fish Oil, Separately or in Combination, on Treatment of Primary Dysmenorrhea: A Double-Blind, Randomized Clinical Trial. Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology (2018). 34(9), 804–808. https://doi.org/10.1080/09513590.2018.1450377.

Santos, Heitor O, James C Price, and Allain A Bueno. Beyond Fish Oil Supplementation: The Effects of Alternative Plant Sources of Omega-3 Polyunsaturated Fatty Acids upon Lipid Indexes and Cardiometabolic Biomarkers-An Overview.” Nutrients (2020). 12(10), 3159. https://doi.org/10.3390/nu12103159.

Sima, Romina-Marina, Mihaela Sulea, Julia Caroline Radosa, Sebastian Findeklee, Bashar Haj Hamoud, Mihai Popescu, Gabriel Petre Gorecki, et al. 2022. “The Prevalence, Management and Impact of Dysmenorrhea on Medical Students’ Lives-A Multicenter Study.” Healthcare (Basel, Switzerland) (2022). 10(1), 157 . https://doi.org/10.3390/healthcare10010157.

Simonetto, Marialaura, Marco Infante, Ralph L Sacco, Tatjana Rundek, and David Della-Morte. A Novel Anti-Inflammatory Role of Omega-3 PUFAs in Prevention and Treatment of Atherosclerosis and Vascular Cognitive Impairment and Dementia. Nutrients (2019). 11(10), 2279. https://doi.org/10.3390/nu11102279.

Stupin, Marko, Aleksandar Kibel, Ana Stupin, Kristina Selthofer-Relatić, Anita Matić, Martina Mihalj, Zrinka Mihaljević, Ivana Jukić, and Ines Drenjančević. The Physiological Effect of N-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Intake and Exercise on Hemorheology, Microvascular Function, and Physical Performance in Health and Cardiovascular Diseases; Is There an Interaction of Exercise and Dietary n-3 PUFA . Frontiers in Physiology (2019), 10, 1129. https://doi.org/10.3389/fphys.2019.01129.

Vena, Walter, and Stavroula A Paschou. Sports and the Menstrual Cycle.” Case Reports in Women’s Health (2022). 33(1), 00367. https://doi.org/10.1016/j.crwh.2021.e00367.

Visioli, Francesco, and Carlo Agostoni. Omega 3 Fatty Acids and Health: The Little We Know after All These Years. Nutrients (2022). 14(2), 239. https://doi.org/10.3390/nu14020239.

Willis, Erin L, Phillip J Bridges, and Joanne E Fortune. Progesterone Receptor and Prostaglandins Mediate Luteinizing Hormone-Induced Changes in Messenger RNAs for ADAMTS Proteases in Theca Cells of Bovine Periovulatory Follicles. Molecular Reproduction and Development (2017). 84(1), 55–66. https://doi.org/10.1002/mrd.22761.

Wu, Po-Kuan, Shu-Ching Yeh, Shan-Jen Li, and Yi-No Kang. Efficacy of Polyunsaturated Fatty Acids on Inflammatory Markers in Patients Undergoing Dialysis: A Systematic Review with Network Meta-Analysis of Randomized Clinical Trials. International Journal of Molecular Sciences (2019). 20(15), 3645. https://doi.org/10.3390/ijms20153645.

Yeom, Wan Woo, Hye Jeong Kim, Kyeong-Ryeol Lee, Hyun Suk Cho, Jin-Young Kim, Ho Won Jung, Seon-Woo Oh, Sang Eun Jun, Hyun Uk Kim, and Young-Soo Chung. Increased Production of α-Linolenic Acid in Soybean Seeds by Overexpression of Lesquerella FAD3-1. Frontiers in Plant Science (2019). 10, 1812. https://doi.org/10.3389/fpls.2019.01812.

Yokoyama, Emi, Takashi Takeda, Zen Watanabe, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Kasumi Sakurai, et al. Association of Fish Intake with Menstrual Pain: A Cross-Sectional Study of the Japan Environment and Children’s Study. PloS One (2022). 17(7), e0269042. https://doi.org/10.1371/journal.pone.0269042.

Zaloga, Gary P. “Narrative Review of N-3 Polyunsaturated Fatty Acid Supplementation upon Immune Functions, Resolution Molecules and Lipid Peroxidation.” Nutrients (2021). 13(2), 662. https://doi.org/10.3390/nu13020662.

Descargas

Publicado

2023-03-31

Cómo citar

Gusti Handayani, S. ., Ayubi, N. ., Komaini, A., Lesmana , H. S. ., Kusnanik , N. W., Herawati, L., Ardha , M. A. A. ., Nurhasan, N., Kafrawi , F. R. ., Putri, D. R. S. ., Ardi Kusuma, D. ., & Putra, A. Y. . (2023). Los ácidos grasos poliinsaturados n-3 (PUFA) y el ejercicio físico tienen el potencial de reducir la intensi-dad del dolor en mujeres con dismenorrea primaria: Systematic Review (N-3 polyunsaturated fatty acids (PUFAs) and physical exercise have the potential to reduce pain intensity in women with primary dysmenorrhea: Systematic Review ). Retos, 48, 106–112. https://doi.org/10.47197/retos.v48.96629

Número

Sección

Revisiones teóricas, sistemáticas y/o metaanálisis

Artículos más leídos del mismo autor/a

1 2 3 4 > >>