La curcumina reduce los niveles de creatina quinasa (CK) sin disminuir los niveles de malondialdehído (MDA) después de 24 horas de ejercicio físico de alta intensidad (Curcumin reduce creatine kinase (CK) levels without decreasing malondialdehyde (MDA) levels after 24 hours of high-intensity physical exercise)


  • Nining Widyah Kusnanik Universitas Negeri Surabaya
  • Novadri Ayubi Universitas Negeri Surabaya
  • Lilik Herawati Universitas Airlangga
  • Tutur Jatmiko Universitas Negeri Surabaya
  • Abd. Muin Shanghai University of Sport
  • Stephen P. Bird University of Southern Queensland (Australia)


Palabras clave:

curcumina, creatina quinasa, malondialdehído, daño muscular, radicales libres, entrenamiento físico


Este estudio tiene como objetivo analizar el efecto de la curcumina sobre los niveles séricos de creatina quinasa (CK) y malondialdehído (MDA) después de 24 horas de ejercicio físico de alta intensidad. Este estudio experimental utilizó un diseño de grupo de control previo y posterior. En este estudio participaron un total de 18 hombres sanos con una edad promedio de 23 años. Los sujetos fueron seleccionados utilizando una técnica de muestreo aleatorio y luego los sujetos fueron divididos en 2 grupos, a saber, el grupo que recibió un placebo y el grupo que recibió curcumina en una dosis de 400 mg. El primer día, todos los sujetos tomaron datos sobre las características de los sujetos de investigación, y luego los sujetos realizaron el ejercicio físico de alta intensidad en forma de ejercicios de escuadra y prensa de piernas con una intensidad de 80-90% de la capacidad máxima. En el segundo día, después de 24 horas, todos los sujetos tomaron muestras de datos previos a la prueba para medir los niveles séricos de CK y MDA, luego se administró la intervención en función de sus respectivos grupos. El tercer día, después de 24 horas, todos los sujetos tomaron muestras de sangre posteriores a la prueba para medir los niveles séricos de CK y MDA. Las muestras de sangre se analizaron en el laboratorio mediante el método ELISA. Los resultados de este estudio informaron que el grupo que recibió un placebo no redujo significativamente los niveles séricos de CK, mientras que el grupo con curcumina en una dosis de 400 mg pudo reducir significativamente los niveles de CK (p<0.05). Además, no hubo una disminución significativa en los niveles séricos de MDA en el grupo de placebo o el grupo de curcumina (p>0.05). Se puede concluir que la administración de curcumina después de 24 horas del entrenamiento con pesas de alta intensidad fue capaz de reducir los niveles séricos de CK sin una disminución de los niveles séricos de MDA. Dado que la disminución en suero, el nivel de CK es una parte esencial de la recuperación durante el daño muscular. Por lo tanto, se recomienda tomar curcumina después de 24 horas después del ejercicio para acelerar la recuperación.

Palabras clave: Curcumina; creatina quinasa; malondialdehído; daño muscular; radicales libres; entrenamiento físico

Abstract. This study aims to analyze the effect of curcumin on serum levels of creatine kinase (CK) and malondialdehyde (MDA) after 24 hours of high-intensity physical exercise. This experimental study used a pre and post-control group design. A total of 18 healthy men with an average age of 23 years participated in this study. Subjects were selected using a random sampling technique and then the subjects were divided into 2 groups, namely the group given a placebo and the group given curcumin at a dose of 400 mg.  On the first day, all subjects took data on the characteristics of the research subjects, and then the subjects did the high-intensity physical exercise in the form of squad and leg press exercises with an intensity of 80-90% of maximum ability.  On the second day, after 24 hours, all subjects took pre-test data samples to measure serum CK and MDA levels, then the intervention was given based on their respective groups. On the third day, after 24 hours, all subjects took post-test blood samples to measure CK and MDA serum levels. Blood samples were analyzed in the laboratory using the ELISA method. The results of this study reported that the group given a placebo did not significantly reduce serum CK levels, while the group with curcumin at a dose of 400 mg could significantly reduce CK levels (p<0.05). Furthermore, there was no significant decrease in serum MDA levels in the placebo group or the curcumin group (p>0.05). It can be concluded that the administration of curcumin after 24 hours after high-intensity weight training was able to reduce serum CK levels without a decrease in MDA serum levels. Since the decrease in serum CK levels is an essential part of recovery during muscle damage. Therefore, curcumin is recommended to be taken after 24 hours after exercise to speed up recovery.

Keywords: Curcumin; creatine kinase; malondialdehyde; muscle damage; free radicals; physical training


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Cómo citar

Kusnanik, N. W., Ayubi, N. ., Herawati, L., Jatmiko, T., Muin, A., & Bird, S. P. . (2023). La curcumina reduce los niveles de creatina quinasa (CK) sin disminuir los niveles de malondialdehído (MDA) después de 24 horas de ejercicio físico de alta intensidad (Curcumin reduce creatine kinase (CK) levels without decreasing malondialdehyde (MDA) levels after 24 hours of high-intensity physical exercise). Retos, 48, 878–882.



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