Effectiveness of therapeutic exercise on the “Unified Huntington´s Disease Rating Scale” in patients diagnosed with Huntington´s Disease
DOI:
https://doi.org/10.47197/retos.v54.99363Keywords:
Exercise Therapy, Huntington´s Disease, Physical Therapy, Rehabilitation, Unified Huntington´s Disease Rating ScaleAbstract
Introduction: Huntington’s Disease is a neurodegenerative disorder of autosomal dominant inheritance which presents progressive motor, cognitive and psychiatric symptoms. There is no cure, only symptomatic treatment. This review is fulfilled with the aim of stablishing if exercise therapy is effective in the treatment of this pathology, according to the results obtained in the Unified Huntington Disease Rating Scale. Methods: A bibliographic search was performed in six databases (PubMed, Cinahl, Sportdiscus, Cochrane, PEDro, and Web of Science) in January 2022, following the Preferred Reported Items for Systematic Reviews and Meta-Analysis. Results: Eight randomized clinical trials were analyzed, among which six studies were found with significant results, with favorable impact on the motor dimension of the UHDRS, in addition to other variables such as heart rate, which are also favored during the intervention; and two studies without positive results for the variable. Conclusions: Exercise therapy seems to be a safe tool in treatment of Huntington’s Disease, as it has been proved that cardiovascular exercise, combined or not with strength training, seems to achieve improvements in the Unified Huntington’s Disease Rating Scale, therefore it has a positive impact on the physical and mental health of this type of patients, although intervention protocols need to be further unified, as well as keep on investigating.
Key Words: Exercise therapy; Huntingon’s Disease; Physical therapy; Rehabilitation; Unified Huntington’s Disease Rating Scale.
References
Al-Wardat, M., Schirinzi, T., Hadoush, H., Kassab, M., Yabroudi, M. A., Opara, J., Nawrat-Szołtysik, A., Khalil, H., & Etoom, M. (2022). Home-Based Exercise to Improve Motor Functions, Cognitive Functions, and Quality of Life in People with Huntington’s Disease: A Systematic Review and Meta-Analysis. International Journal of Environ-mental Research and Public Health, 19(22), 14915. https://doi.org/10.3390/ijerph192214915
Bishnoi, A., Lee, R., Hu, Y., Mahoney, J. R., & Hernandez, M. E. (2022). Effect of Treadmill Training Interventions on Spatiotemporal Gait Parameters in Older Adults with Neurological Disorders: Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Environmental Research and Public Health, 19(5), 2824. https://doi.org/10.3390/ijerph19052824
Blair, S. N., & Morris, J. N. (2009). Healthy Hearts—and the Universal Benefits of Being Physically Active: Physical Activity and Health. Annals of Epidemiology, 19(4), 253-256. https://doi.org/10.1016/j.annepidem.2009.01.019
Busse, M., Quinn, L., Debono, K., Jones, K., Collett, J., Playle, R., Kelly, M., Simpson, S., Backx, K., Wasley, D., Dawes, H., Rosser, A., & Members of the COMMET-HD Management Group. (2013). A randomized feasibility study of a 12-week community-based exercise program for people with Huntington’s disease. Journal of Neuro-logic Physical Therapy: JNPT, 37(4), 149-158. https://doi.org/10.1097/NPT.0000000000000016
Busse, M., Quinn, L., Drew, C., Kelson, M., Trubey, R., McEwan, K., Jones, C., Townson, J., Dawes, H., Tudor-Edwards, R., Rosser, A., & Hood, K. (2017). Physical Activity Self-Management and Coaching Compared to So-cial Interaction in Huntington Disease: Results From the ENGAGE-HD Randomized, Controlled Pilot Feasibility Trial. Physical Therapy, 97(6), 625-639. https://doi.org/10.1093/ptj/pzx031
Caron, N. S., Wright, G. E., & Hayden, M. R. (2020). Huntington Disease. En GeneReviews® [Internet]. University of Washington, Seattle. https://www.ncbi.nlm.nih.gov/books/NBK1305/
Cashin, A. G., & McAuley, J. H. (2020). Clinimetrics: Physiotherapy Evidence Database (PEDro) Scale. Journal of Physiotherapy, 66(1), 59. https://doi.org/10.1016/j.jphys.2019.08.005
Crowell, V., Houghton, R., Tomar, A., Fernandes, T., & Squitieri, F. (2021). Modeling Manifest Huntington’s Disease Prevalence Using Diagnosed Incidence and Survival Time. Neuroepidemiology, 55(5), 361-368. https://doi.org/10.1159/000516767
Dawes, H., Collett, J., Debono, K., Quinn, L., Jones, K., Kelson, M. J., Simpson, S. A., Playle, R., Backx, K., Was-ley, D., Nemeth, A. H., Rosser, A., Izardi, H., & Busse, M. (2015). Exercise testing and training in people with Huntington’s disease. Clinical Rehabilitation, 29(2), 196-206. https://doi.org/10.1177/0269215514540921
Fritz, N. E., Rao, A. K., Kegelmeyer, D., Kloos, A., Busse, M., Hartel, L., Carrier, J., & Quinn, L. (2017). Physical Therapy and Exercise Interventions in Huntington’s Disease: A Mixed Methods Systematic Review. Journal of Hun-tington’s Disease, 6(3), 217-235. https://doi.org/10.3233/JHD-170260
Ghosh, R., & Tabrizi, S. J. (2018). Clinical Features of Huntington’s Disease. En C. Nóbrega & L. Pereira de Almeida (Eds.), Polyglutamine Disorders (Vol. 1049, pp. 1-28). Springer International Publishing. https://doi.org/10.1007/978-3-319-71779-1_1
Jpt, H. (s. f.). Manual Cochrane de revisiones sistemáticas de intervenciones. 639.
Khalil, H., Quinn, L., van Deursen, R., Dawes, H., Playle, R., Rosser, A., & Busse, M. (2013). What effect does a structured home-based exercise programme have on people with Huntington’s disease? A randomized, controlled pilot study. Clinical Rehabilitation, 27(7), 646-658. https://doi.org/10.1177/0269215512473762
Kim, A., Lalonde, K., Truesdell, A., Gomes Welter, P., Brocardo, P. S., Rosenstock, T. R., & Gil-Mohapel, J. (2021). New Avenues for the Treatment of Huntington’s Disease. International Journal of Molecular Sciences, 22(16), 8363. https://doi.org/10.3390/ijms22168363
Luan, X., Tian, X., Zhang, H., Huang, R., Li, N., Chen, P., & Wang, R. (2019). Exercise as a prescription for patients with various diseases. Journal of Sport and Health Science, 8(5), 422-441. https://doi.org/10.1016/j.jshs.2019.04.002
McColgan, P., & Tabrizi, S. J. (2018). Huntington’s disease: A clinical review. European Journal of Neurology, 25(1), 24-34. https://doi.org/10.1111/ene.13413
McGuinness, L. A., & Higgins, J. P. T. (2021). Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. Research Synthesis Methods, 12(1), 55-61. https://doi.org/10.1002/jrsm.1411
Memon, A. A., Coleman, J. J., & Amara, A. W. (2020). Effects of exercise on sleep in neurodegenerative disease. Neurobiology of Disease, 140, 104859. https://doi.org/10.1016/j.nbd.2020.104859
Mueller, S. M., Petersen, J. A., & Jung, H. H. (2019). Exercise in Huntington’s Disease: Current State and Clinical Significance. Tremor and Other Hyperkinetic Movements, 9(0), 601. https://doi.org/10.5334/tohm.515
PEDro_scale_spanish.pdf. (s. f.). Recuperado 2 de mayo de 2022, de https://pedro.org.au/wp-content/uploads/PEDro_scale_spanish.pdf
Quinn, L., Debono, K., Dawes, H., Rosser, A. E., Nemeth, A. H., Rickards, H., Tabrizi, S. J., Quarrell, O., Trender-Gerhard, I., Kelson, M. J., Townson, J., Busse, M., & members of the TRAIN-HD project group. (2014). Task-specific training in Huntington disease: A randomized controlled feasibility trial. Physical Therapy, 94(11), 1555-1568. https://doi.org/10.2522/ptj.20140123
Quinn, L., Hamana, K., Kelson, M., Dawes, H., Collett, J., Townson, J., Roos, R., van der Plas, A. A., Reilmann, R., Frich, J. C., Rickards, H., Rosser, A., & Busse, M. (2016). A randomized, controlled trial of a multi-modal exer-cise intervention in Huntington’s disease. Parkinsonism & Related Disorders, 31, 46-52. https://doi.org/10.1016/j.parkreldis.2016.06.023
Quinn, L., Kegelmeyer, D., Kloos, A., Rao, A. K., Busse, M., & Fritz, N. E. (2020). Clinical recommendations to guide physical therapy practice for Huntington disease. Neurology, 94(5), 217-228. https://doi.org/10.1212/WNL.0000000000008887
Roos, R. A. (2010). Huntington’s disease: A clinical review. Orphanet Journal of Rare Diseases, 5(1), 40. https://doi.org/10.1186/1750-1172-5-40
Salari, N., Hayati, A., Kazeminia, M., Rahmani, A., Mohammadi, M., Fatahian, R., & Shohaimi, S. (2022). The effect of exercise on balance in patients with stroke, Parkinson, and multiple sclerosis: A systematic review and meta-analysis of clinical trials. Neurological Sciences, 43(1), 167-185. https://doi.org/10.1007/s10072-021-05689-y
Shamseer, L., Moher, D., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: Elaboration and explanation. BMJ, 349, g7647. https://doi.org/10.1136/bmj.g7647
Smith, M., Barker, R., Williams, G., Carr, J., & Gunnarsson, R. (2020). The effect of exercise on high-level mobility in individuals with neurodegenerative disease: A systematic literature review. Physiotherapy, 106, 174-193. https://doi.org/10.1016/j.physio.2019.04.003
Stout, J. C., Jones, R., Labuschagne, I., O’Regan, A. M., Say, M. J., Dumas, E. M., Queller, S., Justo, D., Santos, R. D., Coleman, A., Hart, E. P., Dürr, A., Leavitt, B. R., Roos, R. A., Langbehn, D. R., Tabrizi, S. J., & Frost, C. (2012). Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington’s dis-ease. Journal of Neurology, Neurosurgery, and Psychiatry, 83(7), 687-694. https://doi.org/10.1136/jnnp-2011-301940
Sujkowski, A., Hong, L., Wessells, R. J., & Todi, S. V. (2022). The protective role of exercise against age-related neu-rodegeneration. Ageing Research Reviews, 74, 101543. https://doi.org/10.1016/j.arr.2021.101543
The HD Measuring Stick: Assessment Standards for Huntington’s Disease. (2010, julio 7). HOPES Huntington’s Dis-ease Information. https://hopes.stanford.edu/assessment-standards-for-huntingtons-disease-severity/
Thompson, J. A., Cruickshank, T. M., Penailillo, L. E., Lee, J. W., Newton, R. U., Barker, R. A., & Ziman, M. R. (2013). The effects of multidisciplinary rehabilitation in patients with early-to-middle-stage Huntington’s disease: A pilot study. European Journal of Neurology, 20(9), 1325-1329. https://doi.org/10.1111/ene.12053
Trembath, M. K., Horton, Z. A., Tippett, L., Hogg, V., Collins, V. R., Churchyard, A., Velakoulis, D., Roxburgh, R., & Delatycki, M. B. (2010). A retrospective study of the impact of lifestyle on age at onset of Huntington disease. Movement Disorders, 25(10), 1444-1450. https://doi.org/10.1002/mds.23108
Trinkler, I., Chéhère, P., Salgues, J., Monin, M.-L., Tezenas du Montcel, S., Khani, S., Gargiulo, M., & Durr, A. (2019). Contemporary Dance Practice Improves Motor Function and Body Representation in Huntington’s Dis-ease: A Pilot Study. Journal of Huntington’s Disease, 8(1), 97-110. https://doi.org/10.3233/JHD-180315
UHDRS®. (s. f.). Recuperado 16 de mayo de 2022, de https://huntingtonstudygroup.org/uhdrs/
Unified Huntington’s disease rating scale: Reliability and consistency. (1996). Movement Disorders, 11(2), 136-142. https://doi.org/10.1002/mds.870110204
Wyant, K. J., Ridder, A. J., & Dayalu, P. (2017). Huntington’s Disease—Update on Treatments. Current Neurology and Neuroscience Reports, 17(4), 33. https://doi.org/10.1007/s11910-017-0739-9
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Retos
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and ensure the magazine the right to be the first publication of the work as licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of authorship of the work and the initial publication in this magazine.
- Authors can establish separate additional agreements for non-exclusive distribution of the version of the work published in the journal (eg, to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Is allowed and authors are encouraged to disseminate their work electronically (eg, in institutional repositories or on their own website) prior to and during the submission process, as it can lead to productive exchanges, as well as to a subpoena more Early and more of published work (See The Effect of Open Access) (in English).
This journal provides immediate open access to its content (BOAI, http://legacy.earlham.edu/~peters/fos/boaifaq.htm#openaccess) on the principle that making research freely available to the public supports a greater global exchange of knowledge. The authors may download the papers from the journal website, or will be provided with the PDF version of the article via e-mail.