Response of TNF-α Levels and Blood Glucose Levels after Acute High-Intensity Intermittent Exercise in Overweight Women
DOI:
https://doi.org/10.47197/retos.v48.94305Keywords:
Interval exercise, TNF-α, Glucose, Overweight, Sedentar, Healthy lifestyleAbstract
Sedentary behavior is a lifestyle that plays a role in the pathophysiology of obesity or overweight. TNF-α is an inflammatory cytokine that can affect glucose metabolism and can trigger insulin resistance. Acute HIIE is exercise with alternating periods of high-intensity exercise and periods of active recovery. The purpose of this study was to examine the changes of TNF-α and blood glucose levels after acute HIIE in overweight women. Subjects were overweight women, divided into 2 groups (K1=control group and K2=experimental group; n=7) with a body mass index between 23.00 and up to 24.99 kg/m2. The acute protocol of HIIE with ergocycle consisted of a 3-minute warm-up (starting at 40 rpm), core exercise for 60 s at 80%-90% of HRmax, interspersed with 60 s of active recovery (40 rpm), and cool-down for 2 minutes. The pre-test was performed before treatment and the post-test was performed 60 minutes after treatment. Serum TNF-α levels were measured by the human enzyme-linked immunosorbent assay (ELISA) method. Blood glucose levels were taken by finger prick. The result showed that the change of TNF-α (the difference of pre and post) was a significant decrease in the K1 and K2 group (p<0.05), and the K2 group less decrease compared to K1. Blood glucose was significant in the K1 group (p<0.05). This study can be concluded that the TNF-α level is unchanged and the blood glucose levels is increase in overweight women with sedentary behavior performing acute HIIE.
Keywords: Interval exercise; TNF-α; Glucose; Overweight; sedentary lifestyle
References
Abdelmotaleb, G. S., Abdo, M. K., Abdelmonaem, E. R., Ahmed, E. S., & Aboelsoued, A. (2017). Comparative Study Between Measurements of Serum Cholesterol, Uric Acid and Glucose in Children With Β-Thalassemia By Laboratory and Bedside Methods. International Journal of Advanced Research, 5(6), 963–973. https://doi.org/10.21474/ijar01/4498
Antunes, B. M., Campos, E. Z., dos Santos, R. V. T., Rosa-Neto, J. C., Franchini, E., Bishop, N. C., & Lira, F. S. (2019). Anti-inflammatory response to acute exercise is related with intensity and physical fitness. Journal of Cellular Biochemistry, 120(4), 5333–5342. https://doi.org/10.1002/jcb.27810
As’ad, M. R. F., Sari, G. M., Othman, Z., & Herawati, L. (2022). The combination of intermittent caloric restriction and moderate-intensity interval training in decreasing blood glucose and CRP levels with a high glycemic index diet. Kuwait Journal of Science, 49(8.5.2017), 1–11. https://doi.org/10.48129/kjs.12365
Ayubi, N., Purwanto, B., Rejeki, P. S., Kusnanik, N. W., Herawati, L., Komaini, A., Firmansyah, A. (2022). Effect of acute omega 3 supplementation reduces serum tumor necrosis factor-alpha (TNF-a) levels, pain intensity, and maintains muscle strength after high-intensity weight training. Retos, 2041(46), 677–682. https://doi.org/10.47197/retos.v46.93720
Cossio-Bolaños, M. A., Vidal-Espinoza, R., Pino-Valenzuela, M., Luarte-Rocha, C., Rivera-Portugal, M., Sulla-Torres, J., & Gomez-Campos, R. (2020). Body adiposity and levels of physical activity in adolescents. Retos, 37, 205–209.
De Souza, D. C., Matos, V. A. F., dos Santos, V. O. A., Medeiros, I. F., Marinho, C. S. R., Nascimento, P. R. P., Fayh, A. P. T. (2018). Effects of high-intensity interval and moderate-intensity continuous exercise on inflammatory, leptin, IgA, and lipid peroxidation responses in obese males. Frontiers in Physiology, 9(MAY), 1–9. https://doi.org/10.3389/fphys.2018.00567
Dimitrov, S., Hulteng, E., & Hong, S. (2017). Inflammation and exercise: Inhibition of monocytic intracellular TNF production by acute exercise via β2-adrenergic activation. Brain, Behavior, and Immunity, 61, 60–68. https://doi.org/10.1016/j.bbi.2016.12.017
Dorneles, G. P., da Silva, I. R. V., Korb, A., Bertoldi, K., Siqueira, I. R., Elsner, V. R., Peres, A. (2016). High intensity interval exercise enhances the global HDAC activity in PBMC and anti-inflammatory cytokines of overweight-obese subjects. Obesity Medicine, 2, 25–30. https://doi.org/10.1016/j.obmed.2016.05.004
Dos Santos, G. C., Faria, W. F., Sasaki, J. E., Gonçalves Elias, R. M., & Stabelini Neto, A. (2019). Acute effects of physical exercise at different intensities on inflammatory markers in obese adolescents. Journal of Physical Education (Maringa), 30(1), 1–7. https://doi.org/10.4025/jphyseduc.v30i1.3014
Eskandari, M., Asghari, H., Saghebjoo, M., & Kazemi, T. (2021). Short duration moderate resistance training reduces blood pressure and plasma TNF-α in hypertensive men: The importance role of upper and lower body training. Science and Sports, 36(1), e1–e11. https://doi.org/10.1016/j.scispo.2019.12.005
Ferrandi, P. J., Fico, B. G., Whitehurst, M., Zourdos, M. C., Bao, F., Dodge, K. M., Huang, C. J. (2018). Acute high-intensity interval exercise induces comparable levels of circulating cell-free DNA and Interleukin-6 in obese and normal-weight individuals. Life Sciences, 202(April), 161–166. https://doi.org/10.1016/j.lfs.2018.04.007
Garzón Mosquera, J. C., & Aragón Vargas, L. F. (2021). Sedentarismo, actividad física y salud: una revision narrativa (Sedentary lifestyle, physical activity and health: a narrative review). Retos, 42, 478–499. https://doi.org/10.47197/retos.v42i0.82644
Hawari, B. Y., Sugiharto, Merawati, D., & Pranoto, A. (2021). Acute aerobic exercise decreased tumor necrosis factor alpha (Tnf-?) levels in obese adolescent females. Indian Journal of Forensic Medicine and Toxicology, 15(4), 852‐860.
Hayes, L. D., Herbert, P., Sculthorpe, N., & Grace, F. (2020). High intensity interval training (HIIT) produces small improvements in fasting glucose, insulin, and insulin resistance in sedentary older men but not masters athletes. Experimental Gerontology, 140(March), 111074. https://doi.org/10.1016/j.exger.2020.111074
Heydari, M., Freund, J., & Boutcher, S. H. (2012). The effect of high-intensity intermittent exercise on body composition of overweight young males. Journal of Obesity, 2012, 1–9. https://doi.org/10.1155/2012/480467
Marliss, E. B., & Vranic, M. (2002). Intense exercise has unique effects on both insulin release and its roles in glucoregulation: Implications for diabetes. Diabetes, 51(SUPPL.), 271–283. https://doi.org/10.2337/diabetes.51.2007.s271
Nie, J., Kong, Z., Baker, J. S., Tong, T. K., Lei, S. H., & Shi, Q. (2012). Acute changes in glycemic homeostasis in response to brief high-intensity intermittent exercise in obese adults. Journal of Exercise Science and Fitness, 10(2), 97–100. https://doi.org/10.1016/j.jesf.2012.10.007
Petersen, A. M. W., & Pedersen, B. K. (2005). The anti-inflammatory effect of exercise. Journal of Applied Physiology, 98(4), 1154–1162. https://doi.org/10.1152/japplphysiol.00164.2004
Salvador Soler, N., Bruneau Chávez, J. G., & Godoy Cumillaf, A. E. R. (2019). Nutritional status, dietary intake, and blood glucose levels in Physical Education students. Retos, 2041(36), 510–514. https://doi.org/10.47197/retos.v36i36.71246
Segovia, Y., & Gutiérrez, D. (2020). Perception of Exertion, involvement and physical fitness in a HIIT Program in Physical Education. Retos, (38), 151–158. https://doi.org/10.47197/retos.v38i38.73686
Sherwood, L. (2016). Human Physiology : From Cells to Systems (Ninth Edit; Graphic World Inc, ed.). USA.
Suárez Manzano, S., Belchior de Oliveira, P., Rusillo Magdaleno, A., & Ruiz Ariza, A. (2022). Effect of a C-HIIT program in the inhibitory control and behaviour of young ADHD. Retos, (45), 878–885. https://doi.org/10.47197/retos.v45i0.92903
Susantiningsih, T., & Mustofa, S. (2018). Ekspresi IL-6 dan TNF- α Pada Obesitas IL-6 and TNF- α Expression in Obesity. JK Unila, 2(2), 174–180.
Van Der Kolk, B. W., Kalafati, M., Adriaens, M., Van Greevenbroek, M. M. J., Vogelzangs, N., Saris, W. H. M., Blaak, E. E. (2019). Subcutaneous adipose tissue and systemic inflammation are associated with peripheral but not hepatic insulin resistance in humans. Diabetes, 68(12), 2247–2258. https://doi.org/10.2337/db19-0560
Vigriawan, G. E., Putri, E. A. C., Rejeki, P. S., Qurnianingsih, E., Kinanti, R. G., Mohamed, M. N. A., & Herawati, L. (2022). High-intensity interval training improves physical performance without C-reactive protein (CRP) level alteration in overweight sedentary women. Journal of Physical Education and Sport, 22(2), 442–447. https://doi.org/10.7752/jpes.2022.02055
Yurida, Y., & Huzaifah, Z. (2019). Pengaruh Jalan Kaki Terhadap Kadar Gula Darah Pada Pasien Diabetes Mellitus Tipe II. Dinamika Kesehatan Jurnal Kebidanan Dan Keperawatan, 10(2), 911–915. https://doi.org/10.33859/dksm.v10i2.468
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