Citrus Limon tiene el potencial de reducir el estrés oxidativo y la inflamación después de la actividad física/ejercicio: revisión sistemática (Citrus Limon Has the Potential to Reduce Oxidative Stress and Inflammation After Physical Activity/Exercise: Systematic Review)
DOI:
https://doi.org/10.47197/retos.v51.101541Palabras clave:
Citrus Limon, Oxydative Stress, Inflammation, Physical training, Healthy LifestyleResumen
Este estudio tiene como objetivo analizar y resaltar el potencial del limón cítrico para reducir la inflamación y el estrés oxidativo después de la actividad/ejercicio físico. Este estudio utiliza un método de revisión sistemática mediante la búsqueda en varias bases de datos de revistas como Scopus, Web of Science, Pubmed y Embase. Los criterios de inclusión en este estudio fueron artículos publicados en los últimos 5 años y artículos sobre Limón, Inflamación, Radicales Libres y ejercicio físico. Los criterios de exclusión en este estudio fueron artículos publicados en revistas de mala reputación. Se identificaron un total de 1665 artículos de las bases de datos Scopus, Web of Science Pubmed y Embase. Para esta revisión sistemática se seleccionaron y analizaron un total de 7 artículos que cumplieron con los criterios de inclusión. Para operaciones estándar, este estudio sigue la evaluación de elementos de informe preferidos para revisión sistemática y metanálisis (PRISMA). Los resultados de esta revisión sistemática de la investigación informan que el contenido de flavonoides que se encuentra en el limón cítrico tiene propiedades antioxidantes que pueden reducir el estrés oxidativo. Además, las propiedades antiinflamatorias del limón cítrico pueden reducir la inflamación incontrolada debida a la actividad física y al ejercicio intenso. En este caso, el limón cítrico actúa inhibiendo la inflamación a través de la señalización de NF-kB y reduciendo la inflamación al suprimir la secreción de citoquinas proinflamatorias como el TNF-a. Reducir la inflamación puede potencialmente reducir la intensidad del dolor muscular. Recomendamos el uso del limón cítrico en individuos para reducir el estrés oxidativo y la inflamación causada por la actividad física y el ejercicio intenso.
Palabras clave: Cítrico Limón; Estrés Oxidativo; Inflamación; Entrenamiento físico; Estilo de vida saludable
Abstract. This study aims to analyze and highlight the potential of citrus limon in reducing inflammation and oxydatif stress after physical activity/exercise. This study uses a systematic review method by searching various journal databases such as Scopus, Web of Science, Pubmed, and Embase. The inclusion criteria in this study were articles published within the last 5 years and articles discussing Limon, Inflammation, Free Radicals, and physical exercise. Exclusion criteria in this study were articles published in disreputable journals. A total of 1665 articles from Scopus, Web of Science Pubmed and Embase databases were identified. A total of 7 articles that met the inclusion criteria were selected and analyzed for this systematic review. For standard operations, this study follows the Preferred Reporting Items for Systematic review and Meta-Analyses (PRISMA) assessment. The results of this systematic research review report that the flavanoid content found in citrus limon has anti-oxidant properties that can reduce oxidative stress. Furthermore, the anti-inflammatory properties of citrus limon can reduce uncontrolled inflammation due to physical activity and intense exercise. In this case, citrus limon works by inhibiting inflammation through NF-kB signaling and reducing inflammation by suppressing the secretion of pro-inflammatory cytokines such as TNF-a. Reducing inflammation can potentially reduce the intensity of muscle pain. We recommend that citrus limon be used in individuals to reduce oxidative stress and inflammation caused by physical activity and intense exercise.
Keywords: Citrus Limon; Oxydative Stress; Inflammation; Physical training; Healthy Lifestyle
Citas
Acar, L., Atalan, N., Karagedik, E. H., & Ergen, A. (2018). Tumour Necrosis Factor-alpha and Nuclear Factor-kappa B Gene Variants in Sepsis. Balkan Medical Journal, 35(1), 30–35. https://doi.org/10.4274/balkanmedj.2017.0246
Anugrah, S. M., Kusnanik, N. W., Wahjuni, E. S., Ayubi, N., & Mulyawan, R. (2023). Effect of Royal Jelly on Performance and Inflammatory Response to Muscle Damage: A Systematic Review. Biointerface Research in Applied Chemistry, 13(5), 6–13. https://doi.org/10.33263/BRIAC135.479
Ayubi, N., Purwanto B., Rejeki, P. S., Kusnanik, N. W., & Herawati, L. (2022). Effect of acute omega 3 supplementation reduces serum tumor necrosis factor-alpha (TNF-a) levels, pain intensity, and maintains muscle strength after high-intensity weight training. Retos, 46, 677–682.
Ayubi, N., Yuniarti, E., Kusnanik, N. W., Herawati, L., Indika, P. M., Putra, R. Y., & Komaini, A. (2022). Acute effects of n-3 polyunsaturated fatty acids ( PUFAs ) reducing tumor necrosis factor-alpha ( TNF- a ) levels and not lowering malondialdehyde ( MDA ) levels after anaerobic exercise. 36(1), 7–11.
Bao, G., Zhang, Y., & Yang, X. (2020). Effect of lemon peel flavonoids on anti-fatigue and anti-oxidation capacities of exhaustive exercise mice. Applied Biological Chemistry, 63(1). https://doi.org/10.1186/s13765-020-00573-3
Buchwald-Werner, S., Naka, I., Wilhelm, M., Schütz, E., Schoen, C., & Reule, C. (2018). Effects of lemon verbena extract (Recoverben®) supplementation on muscle strength and recovery after exhaustive exercise: a randomized, placebo-controlled trial. Journal of the International Society of Sports Nutrition, 15(1), 5. https://doi.org/10.1186/s12970-018-0208-0
Chang, W. D., Lin, H. Y., Chang, N. J., & Wu, J. H. (2021). Effects of 830 nm Light-Emitting Diode Therapy on Delayed-Onset Muscle Soreness. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2021/6690572
Cherian, D., Peter, T., Narayanan, A., Madhavan, S., Achammada, S., & Vynat, G. (2019). Malondialdehyde as a marker of oxidative stress in periodontitis patients. Journal of Pharmacy and Bioallied Sciences. https://doi.org/10.4103/JPBS.JPBS_17_19
Darenskaya, M. A., Kolesnikova, L. I., & Kolesnikov, S. I. (2021). Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction. Bulletin of Experimental Biology and Medicine, 171(2), 179–189. https://doi.org/10.1007/s10517-021-05191-7
Eddaikra, A., & Eddaikra, N. (2021). Endogenous Enzymatic Antioxidant Defense and Pathologies (V. Waisundara (ed.); p. Ch. 26). IntechOpen. https://doi.org/10.5772/intechopen.95504
El Assar, M., Álvarez-Bustos, A., Sosa, P., Angulo, J., & Rodríguez-Mañas, L. (2022). Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging. International Journal of Molecular Sciences, 23(15). https://doi.org/10.3390/ijms23158713
Fang, X., Azain, M., Crowe-White, K., Mumaw, J., Grimes, J. A., Schmiedt, C., Barletta, M., Rayalam, S., & Park, H. J. (2019). Effect of Acute Ingestion of Green Tea Extract and Lemon Juice on Oxidative Stress and Lipid Profile in Pigs Fed a High-Fat Diet. Antioxidants (Basel, Switzerland), 8(6). https://doi.org/10.3390/antiox8060195
Fernández-Lázaro, D., Mielgo-Ayuso, J., Calvo, J. S., Martínez, A. C., García, A. C., & Fernandez-Lazaro, C. I. (2020). Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: A systematic review. In Nutrients. https://doi.org/10.3390/nu12020501
Hajam, Y. A., Rani, R., Ganie, S. Y., Sheikh, T. A., Javaid, D., Qadri, S. S., Pramodh, S., Alsulimani, A., Alkhanani, M. F., Harakeh, S., Hussain, A., Haque, S., & Reshi, M. S. (2022). Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives. Cells, 11(3). https://doi.org/10.3390/cells11030552
Harahap, N. S., Manalu, N., Siregar, N. S., & Machrina, Y. (2023). Effect of Massage Therapy with Lime (Citrus Aurantifolia) Essential Oil on the Recovery of Delayed Onset of Muscle Soreness in Athletes. Medical Archives (Sarajevo, Bosnia and Herzegovina), 77(1), 24–28. https://doi.org/10.5455/medarh.2023.77.24-28
Hung, B. L., Sun, C. Y., Chang, N. J., & Chang, W. D. (2021). Effects of Different Kinesio-Taping Applications for Delayed Onset Muscle Soreness after High-Intensity Interval Training Exercise: A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2021/6676967
Kafrawi, F. R., Nurhasan, Wahjuni, E. S., Ayubi, N., Muhammad, H. N., Kusnanik, N. W., & Komaini, A. (2023). Massage Has the Potential to Accelerate Recovery and Decrease Muscle Soreness after Physical Exercise (Literature Review). International Journal of Human Movement and Sports Sciences, 11(1), 170–175. https://doi.org/10.13189/saj.2023.110120
Klimek-Szczykutowicz, M., Szopa, A., & Ekiert, H. (2020). Citrus limon (Lemon) Phenomenon-A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and Cosmetics Industries, and Biotechnological Studies. Plants (Basel, Switzerland), 9(1). https://doi.org/10.3390/plants9010119
Magurano, F., Sucameli, M., Picone, P., Micucci, M., Baggieri, M., Marchi, A., Bucci, P., Gioacchini, S., Catinella, G., Borgonovo, G., Dallavalle, S., Nuzzo, D., & Pinto, A. (2021). Antioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular Models. Antioxidants (Basel, Switzerland), 10(11). https://doi.org/10.3390/antiox10111794
Mahmoud, A. M., Hernández Bautista, R. J., Sandhu, M. A., & Hussein, O. E. (2019). Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health. Oxidative Medicine and Cellular Longevity, 2019, 5484138. https://doi.org/10.1155/2019/5484138
Marshall, J. S., Warrington, R., Watson, W., & Kim, H. L. (2018). An introduction to immunology and immunopathology. Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 14(Suppl 2), 49. https://doi.org/10.1186/s13223-018-0278-1
McKeegan, K., Mason, S. A., Trewin, A. J., Keske, M. A., Wadley, G. D., Della Gatta, P. A., Nikolaidis, M. G., & Parker, L. (2021). Reactive oxygen species in exercise and insulin resistance: Working towards personalized antioxidant treatment. Redox Biology, 44, 102005. https://doi.org/10.1016/j.redox.2021.102005
Nanavati, K., Rutherfurd-Markwick, K., Lee, S. J., Bishop, N. C., & Ali, A. (2022). Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review. European Journal of Nutrition. https://doi.org/10.1007/s00394-022-02943-7
Norouzi, F., Doulah, A., & Rafieirad, M. (2020). Effects of Four Week Consumption of Lemon (Citrus limon L.) Essential Oil with Swimming Training on Lipid Profile and Lipid Peroxidation in Adult Male Mice TT - تأثیر چهار هفته مصرف اسانس لیموترش همراه با تمرین شنا بر فاکتورهای لیپیدی و پراکسیداسیون لیپی. Iranian-J-Nutr-Sci-Food-Technol, 14(4), 1–8. http://nsft.sbmu.ac.ir/article-1-2767-en.html
Overdevest, E., Wouters, J. A., Wolfs, K. H. M., van Leeuwen, J. J. M., & Possemiers, S. (2018). Citrus Flavonoid Supplementation Improves Exercise Performance in Trained Athletes. Journal of Sports Science & Medicine, 17(1), 24–30.
Raimondo, S., Urzì, O., Meraviglia, S., Di Simone, M., Corsale, A. M., Rabienezhad Ganji, N., Palumbo Piccionello, A., Polito, G., Lo Presti, E., Dieli, F., Conigliaro, A., & Alessandro, R. (2022). Anti-inflammatory properties of lemon-derived extracellular vesicles are achieved through the inhibition of ERK/NF-κB signalling pathways. Journal of Cellular and Molecular Medicine, 26(15), 4195–4209. https://doi.org/10.1111/jcmm.17404
Ruegsegger, G. N., & Booth, F. W. (2018). Health benefits of exercise. Cold Spring Harbor Perspectives in Medicine. https://doi.org/10.1101/cshperspect.a029694
Simioni, C., Zauli, G., Martelli, A. M., Vitale, M., Sacchetti, G., Gonelli, A., & Neri, L. M. (2018). Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget, 9(24), 17181–17198. https://doi.org/10.18632/oncotarget.24729
Sonkodi, B. (2021). Delayed Onset Muscle Soreness (DOMS): The Repeated Bout Effect and Chemotherapy-Induced Axonopathy May Help Explain the Dying-Back Mechanism in Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases. Brain Sciences, 11(1). https://doi.org/10.3390/brainsci11010108
Thirupathi, A., Wang, M., Lin, J. K., Fekete, G., István, B., Baker, J. S., & Gu, Y. (2021). Effect of Different Exercise Modalities on Oxidative Stress: A Systematic Review. BioMed Research International, 2021, 1947928. https://doi.org/10.1155/2021/1947928
Wang, F., Wang, X., Liu, Y., & Zhang, Z. (2021). Effects of Exercise-Induced ROS on the Pathophysiological Functions of Skeletal Muscle. In Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2021/3846122
Yang, J., Lee, S.-Y., Jang, S.-K., Kim, K.-J., & Park, M.-J. (2023). Anti-Inflammatory Effects of Essential Oils from the Peels of Citrus Cultivars. Pharmaceutics, 15(6). https://doi.org/10.3390/pharmaceutics15061595
Zhang, J.-M., & An, J. (2007). Cytokines, inflammation, and pain. International Anesthesiology Clinics, 45(2), 27–37. https://doi.org/10.1097/AIA.0b013e318034194e
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2023 Retos
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
Los autores que publican en esta revista están de acuerdo con los siguientes términos:
- Los autores conservan los derechos de autor y garantizan a la revista el derecho de ser la primera publicación de su obra, el cuál estará simultáneamente sujeto a la licencia de reconocimiento de Creative Commons que permite a terceros compartir la obra siempre que se indique su autor y su primera publicación esta revista.
- Los autores pueden establecer por separado acuerdos adicionales para la distribución no exclusiva de la versión de la obra publicada en la revista (por ejemplo, situarlo en un repositorio institucional o publicarlo en un libro), con un reconocimiento de su publicación inicial en esta revista.
- Se permite y se anima a los autores a difundir sus trabajos electrónicamente (por ejemplo, en repositorios institucionales o en su propio sitio web) antes y durante el proceso de envío, ya que puede dar lugar a intercambios productivos, así como a una citación más temprana y mayor de los trabajos publicados (Véase The Effect of Open Access) (en inglés).
Esta revista sigue la "open access policy" de BOAI (1), apoyando los derechos de los usuarios a "leer, descargar, copiar, distribuir, imprimir, buscar o enlazar los textos completos de los artículos".
(1) http://legacy.earlham.edu/~peters/fos/boaifaq.htm#openaccess
