Ionizing radiation received by patients with osteosarcoma during intra-arterial chemotherapy treatment
DOI:
https://doi.org/10.23938/ASSN.0009Keywords:
Ionizing radiation. Interventional radiology. Paediatrics. Osteosarcoma.Abstract
Background. Osteosarcoma paediatric patients are usually treated with intra-arterial chemotherapy (QTia) which is administered directly to the tumour. This procedure exposes patients to ionizing radiation. Paediatric patients are especially sensitive to this exposure.
Methods. The total amount of ionizing radiation received from QTia administration was quantified in a group of 16 osteosarcoma paediatric patients from the Clínica Universidad de Navarra.
Results. The median of the total radiation received per patient was 33.4 Gy·cm2 (IQR: 43.33 Gy·cm2), and the median number of procedures performed per subject was 10 (IQR: 6.5).
Conclusions. The study highlights the importance of quantifying the radiation received by a group of children and adolescents affected by osteosarcoma during treatment with QTia. Long-term side effects of this radiation should be considered in paediatric patients. Currently, there are no previous studies that provide data of the amount of ionizing radiation received through this procedure.
Downloads
References
KHONG PL, RINGERTZ H, DONOGHUE V, FRUSH D, REHANI M, APPELGATE K, et al. ICRP publication 121: radiological protection in paediatric diagnostic and interventional radiology. Ann ICRP 2013; 42: 1-63.
IAEA. Radiation protection in paediatric radiology. Vienna: International Atomic Energy Agency (IAEA) 2012. Report No.: 71.
RODRÍGUEZ-GALINDO C. Osteosarcoma. En: Sierrasesúmaga L, Antillón F, editor. Tratado de Oncología Pediátrica: enfermedades malignas del niño y del adolescente. Madrid: Pearson Prentice Hall; 2006. p. 638-651.
JAFFE N. Historical perspective on the introduction and use of chemotherapy for the treatment of osteosarcoma. Adv Exp Med Biol 2014; 804: 1-30.
VANO CARRUANA E, FERNÁNDEZ SOTO JM, SÁNCHEZ CASANUEVA RM, TEN MORON JI. Niveles de referencia de dosis en radiología intervencionista. Radiologia 2013; 55 Suppl. 2: 17-24.
BAJPAI J, JAFFE N. Perspectives of the role of chemotherapy in the management of osteosarcoma. J Cancer Ther 2012; 3: 1191-1203.
VANO E, SÁNCHEZ R, FERNÁNDEZ JM, GALLEGO JJ, VERDÚ JF, DE GARAY MG et al. Patient dose reference levels for interventional radiology: a national approach. Cardiovasc Intervent Radiol 2009; 32: 19-24.
UNSCEAR. Summary of low dose-radiation effects on health. New York: United Nations Scientific Committee on the effects of Atomic Radiation; 2010.
ICRP. The 2007 Recommendations of the International Commission on Radiological Protection. ICRP publication 103. Ann ICRP. 2007; 37(2-4):1-332.
Downloads
Additional Files
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Anales del Sistema Sanitario de Navarra
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
La revista Anales del Sistema Sanitario de Navarra es publicada por el Departamento de Salud del Gobierno de Navarra (España), quien conserva los derechos patrimoniales (copyright ) sobre el artículo publicado y favorece y permite la difusión del mismo bajo licencia Creative Commons Reconocimiento-CompartirIgual 4.0 Internacional (CC BY-SA 4.0). Esta licencia permite copiar, usar, difundir, transmitir y exponer públicamente el artículo, siempre que siempre que se cite la autoría y la publicación inicial en Anales del Sistema Sanitario de Navarra, y se distinga la existencia de esta licencia de uso.
