Whole body PET/CT imaging for detection of metastatic choroidal melanoma

Authors

  • N. A. Rodríguez Marco Complejo Hospitalario de Navarra A
  • C. Caicedo-Zamudio
  • S. Solanas-Álava
  • I. Gil-Arnaiz
  • A. Córdoba-Iturriagagoitia
  • J. Andonegui-Navarro

DOI:

https://doi.org/10.23938/ASSN.0347

Keywords:

Choroidal melanoma. Positron emission tomography. 18-F-FDG. Liver metastasis.

Abstract

Choroidal melanoma is the most common primary intraocular cancer in adults. Metastases are most commonly found in the liver and are rapidly fatal despite aggressive therapy. These metastases have been reported in the follow-up to 50 % of uveal melanoma. However, recent reports have shown that liver ultrasonography and liver function tests have low sensitivity in the diagnosis of metastatic uveal melanoma.

The study reports on a patient with a history of choroidal melanoma. Preoperative medical evaluation, including CT imaging of the abdomen, complete blood count and liver enzymes proved negative. A PET/CT was requested and showed lesions in the liver and lungs. Whole-body PET/CT revealed melanoma metastases.

The PET/CT is a sensitive tool for the detection and localization of hepatic and extrahepatic metastatic choroidal melanoma.

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References

1. DE PALMA P, FRANCO F, BRAGLIANI G, MICHETTI L, MARESCOTTI A, PIRAZZOLI G et al. The incidence of optic neuropathy in 84 patients treated with ethambutol. Metab Pediatr Syst Ophthalmol 1989;12: 80-82.

2. BALAL M, PAYDAS S, SEYREK N, KARAYAYLALI I. Loss of vision and renal function in a patient with miliary tuberculosis. Mt Sinai J Med 2005; 72: 124-126.

3. KOCABAY G, ERELEL M, TUTKUN IT, ECDER T. Optic neuritis and bitemporalhemianopsia associated with isoniazid treatment in end-stage renal failure. Int J Tuberc Lung Dis 2006; 10: 1418-1419.

4. FURIA M, HAMARD H, GÉROLAMI I. Neuropathie optique toxique bilaterale a l'ethambutol et a l'isoniazide. Bull Soc Ophtalmol Fr 1986; 86: 1421-1422.

5. BOULANOUAR A, ABDALLAH E, EL BAKKALI M, BENCHRIFA F, BERRAHO-HAMANI A. Neuropathies optiques toxiques graves induites par l'isoniazide. A propos de trois cas. J Fr Ophtalmol 1995; 18:183-187.

6. CHAN RY, KWOK AK.Ocular toxicity of ethambutol. Hong Kong Med J 2006; 12: 56-60.

7. TALBERT ESTLIN KA, SADUN AA. Risk factors for ethambutol optic toxicity. Int Ophthalmol 2010; 30: 63-72.

https://doi.org/10.1007/s10792-009-9293-z

8. RAMOS MARTÍNEZ A, PORTERO GARCÍA JL, MURILLAS J, LOSADA I, MARTÍN H. Encefalopatía tóxica por isoniacida. Rev Neurol 1998; 26: 160.

https://doi.org/10.33588/rn.26149.981105

9. SHINDLER KS, ZURAKOWSKI D, DREYER EB. Caspase inhibitors block zinc-chelator induced death of retinal ganglion cells. Neuroreport 2000; 11: 2299-2302.

https://doi.org/10.1097/00001756-200007140-00046

10. HENG JE, VORWERCK CK, LESSELL E, ZURAKOWSKI D, LEVIN LA, DREYER EB. Ethambutol is toxic to retinal ganglion cells via an excitotoxic pathway. Invest Ophthalmol Vis Sci 1999; 40: 190-196.

11. LAI TY, CHAN WM, LAM DS, LIM E. Multifocal electroretinogram demonstrated macular toxicity associated with ethambutol related optic neuropathy. Br J Ophthalmol 2005; 89: 774-775.

https://doi.org/10.1136/bjo.2004.058099

12. KAHANA LM. Toxic ocular effects ofethambutol. CMAJ 1987; 137: 212-216.

13. STECHSCHULTE SU, KIM RY, CUNNINGHAM ET JR. Tuberculousneuroretinitis. J Neuroophthalmol 1999; 19: 201-204.

https://doi.org/10.1097/00041327-199909000-00009

14. MANSOUR AM. Optic disk tubercle. J Neuroophthalmol 1998; 18: 201-203.

https://doi.org/10.1097/00041327-199809000-00011

15. AKHADDAR A, EL HASSANI MY, CHAKIR N, JIDDANE M. Tuberculomeoptochiasmatique: complication d'une méningite tuberculeuse. À propos d'un cas et revue de la littérature. J Neuroradiol 2001; 28: 137-142.

16. LIM SA. Ethambutol-associated optic neuropathy. Ann Acad Med Singapore 2006; 35: 274-278.

https://doi.org/10.47102/annals-acadmedsg.V35N4p274

17. SIVAKUMARAN P, HARRISON AC, MARSCHNER J, MARTIN P. Ocular toxicity from ethambutol: a review of four cases and recommended precautions. N Z Med J 1998; 111: 428-430.

18. KUMAR A, SANDRAMOULI S, VERMA L, TEWARI HK, KHOSLA PK. Ocular ethambutol toxicity: is it reversible? J Clin Neuroophthalmol 1993; 13: 15-17.

19. TSAI RK, LEE YH. Reversibility of ethambutol optic neuropathy. J Ocul Pharmacol Ther 1997; 13: 473-477.

https://doi.org/10.1089/jop.1997.13.473

20. CHAI SJ, FOROOZAN R. Decreased retinal nerve fibre layer thickness detected by optical coherence tomography in patients with ethambutol-induced optic neuropathy. Br J Ophthalmol 2007; 91: 895-897.

https://doi.org/10.1136/bjo.2006.113118

Published

2014-06-30

How to Cite

1.
Rodríguez Marco NA, Caicedo-Zamudio C, Solanas-Álava S, Gil-Arnaiz I, Córdoba-Iturriagagoitia A, Andonegui-Navarro J. Whole body PET/CT imaging for detection of metastatic choroidal melanoma. An Sist Sanit Navar [Internet]. 2014 Jun. 30 [cited 2026 Feb. 1];37(2):293-8. Available from: https://recyt.fecyt.es/index.php/ASSN/article/view/24656

Issue

Section

Clinical notes

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