Predictors of mortality and poor outcome in cancer patients with E. faecium bloodstream infection
DOI:
https://doi.org/10.23938/ASSN.0055Keywords:
Bloodstream infection. Enterococcus faecium. Cancer. Predictors.Abstract
Background. To analyze predictors of mortality and poor outcome in cancer patients diagnosed with E. faecium bloodstream infection.
Methods. Demographic, clinical and microbiological data were collected (January 1998-June 2011).
Results. After multivariate analysis, presence of a urinary catheter was associated with a worse 7-day prognosis, and higher mortality at discharge. A high Charlson index was also associated with higher 7-day mortality.
Conclusion. Presence of a urinary catheter was associated with poor 7-day prognosis and higher mortality at discharge in the present series.
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1. MARTÍNEZ-MARCOS FJ, LOMAS-CABEZAS JM, HIDALGO-TENORIO C, DE LA TORRE-LIMA J, PLATA-CIEZAR A, REGUERA-IGLESIAS JM et al. Grupo para el Estudio de las Infecciones Cardiovasculares de la Sociedad Andaluza de Enfermedades Infecciosas. Endocarditis por enterococo: análisis multicéntrico de 76 casos. Enferm Infecc Microbiol Clin 2009; 27: 571-579.
https://doi.org/10.1016/j.eimc.2009.02.007
2. SAVA IG, HEIKENS E, HUEBNER J. Pathogenesis and immunity in enterococcal infections. Clin Microbiol Infect 2010; 16: 533-540.
https://doi.org/10.1111/j.1469-0691.2010.03213.x
3. MCKINNELL JA, PATEL M, SHIRLEY RM, KUNZ DF, MOSER SA, BADDLEY JW. Observational study of the epidemiology and outcomes of vancomycin-resistant enterococcus bacteraemia treated with newer antimicrobial agents. Epidemiol Infect 2011; 139: 1342-1350.
https://doi.org/10.1017/S0950268810002475
4. CONDE-ESTÉVEZ D, GRAU S, ALBANELL J, TERRADAS R, SALVADO M, KNOBEL H. Clinical characteristics and outcomes of patients with vancomycin-susceptible Enterococcus faecalis and Enterococcus faecium bacteraemia in cancer patients. Eur J Clin Microbiol Infect Dis 2011; 30: 103-108.
https://doi.org/10.1007/s10096-010-1029-5
5. MARTÍNEZ-ODRIOZOLA P, MUÑOZ-SÁNCHEZ J, GUTIÉRREZ-MACÍAS A, ARRIOLA-MARTÍNEZ P, MONTERO-APARICIO E, EZPELETA-BAQUEDANO C et al. Análisis de 182 episodios de bacteriemia por enterococo: Estudio de la epidemiología, microbiología, y evolución clínica. Enferm Infecc Microbiol Clin 2007; 25: 503-507.
https://doi.org/10.1157/13109986
6. MCBRIDE SJ, UPTON A, ROBERTS SA. Clinical characteristics and outcomes of patients with vancomycin-susceptible Enterococcus faecalis and Enterococcus faecium bacteraemia-a five-year retrospective review. Eur J Clin Microbiol Infect Dis 2010; 29: 107-114.
https://doi.org/10.1007/s10096-009-0830-5
7. CANTÓN R, RUIZ-GARBAJOSA P. Infecciones causadas por bacterias grampositivas multirresistentes (Staphylococcus aureus y Enterococcus spp.). Enferm Infecc Microbiol Clin 2013; 31: 543-551.
https://doi.org/10.1016/j.eimc.2013.08.001
8. ENVIN-HELICS. Estudio Nacional de vigilancia de infección nosocomial en Servicio de Medicina Intensiva. Sociedad Española de Medicina Intensiva Crítica y Unidades Coronarias (SEMICYUC) Grupo de trabajo de Enfermedades Infecciosas. 2011; http://hws.vhebron.net/envin-helics/Help/Informe%20ENVIN-UCI%202011.pdf
9. LANDRY SL, KAISER DL, WENZEL RP. Hospital stay and mortality attributed to nosocomial enterococcal bacteremia: a controlled study. Am J Infect Control 1989; 17: 323-329.
https://doi.org/10.1016/0196-6553(89)90001-1
10. LAUTENBACH E, BILKER WB, BRENNAN PJ. Enterococcal bacteremia: risk factors for vancomycin resistance and predictors of mortality. Infect Control Hosp Epidemiol 1999; 20: 318-323.
https://doi.org/10.1086/501624
11. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis 1987; 40: 373-383.
https://doi.org/10.1016/0021-9681(87)90171-8
12. CHARLSON M, SZATROWSKI TP, PETERSON J, GOLD J. Validation of a combined comorbidity index. J Clin Epidemiol 1994; 47: 1245-1251.
https://doi.org/10.1016/0895-4356(94)90129-5
13. LEVY MM, FINK MP, MARSHALL JC, ABRAHAM E, ANGUS D, COOK et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 2003; 29: 530-538.
https://doi.org/10.1007/s00134-003-1662-x
14. CABALLERO-GRANADO FJ, BECERRIL B, CUBEROS L, BERNABEU M, CISNEROS JM, PACHÓN J. Attributable mortality rate and duration of hospital stay associated with enterococcal bacteremia. Clin Infect Dis 2001; 32: 587-594.
https://doi.org/10.1086/318717
15. PATTERSON JE, SWEENEY AH, SIMMS M, CARLEY N, MANGI R, SABETTA J et al. An analysis of 110 serious enterococcal infections. epidemiology, antibiotic susceptibility, and outcome. Medicine (Baltimore) 1995; 74: 191-200.
https://doi.org/10.1097/00005792-199507000-00003
16. FORTÚN J, COQUE TM, MARTÍN-DÁVILA P, MORENO L, CANTÓN R, LOZA E et al. Risk factors associated with ampicillin resistance in patients with bacteraemia caused by Enterococcus faecium. J Antimicrob Chemother 2002; 50: 1003-1009.
https://doi.org/10.1093/jac/dkf216
17. AKKOYUN S, KULOGLU F, TOKUC B. Etiologic agents and risk factors in nosocomial urinary tract infections. [Article in Turkish]. Mikrobiyol Bul 2008; 42: 245-254.
18. FURUNO JP, HARRIS AD, WRIGHT MO, MCGREGOR JC, VENEZIA RA, ZHU J et al. Prediction rules to identify patients with methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci upon hospital admission. Am J Infect Control 2004; 32: 436-440.
https://doi.org/10.1016/j.ajic.2004.03.009
19. NAZAR JR, LAVADOS A, DAHER O, BISCHOFF MC. Análisis microbiológico y epidemiológico, y evolución clínica de los pacientes con bacteriemia en el Hospital de Zona de Esquel en el periodo 2007-2009. Rev Argent Microbiol 2010; 42: 151-164.
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