Adherence to treatment with erythropoiesis stimulating agents
DOI:
https://doi.org/10.23938/ASSN.0858Keywords:
Anemia. Chronic kidney failure. Therapeutic adherence. Erythropoietin. Epoetin alfa.Abstract
Background. To establish adherence to treatment with erythropoiesis stimulating agents (ESA) in patients with anemia associated to chronic kidney disease (CKD), and analyze its relationship to response to ESA.
Methods. Retrospective study of a cohort of 198 patients with CKD who started treatment with epoetin-β or darbepoetin-α, followed for two years. Basal characteristics, effectiveness (% of hemoglobin (Hb) target attainment, percentage increase of Hb) and adherence (medication possession rate) were registered. A non-adherent patient was one whose mean adherence was <90%.
Results. Average global adhesion was 89.6%, slightly higher in treatment with darbepoetin α than with epoetin β; 8.6% of patients were non-adherents. Hb target was accomplished in 87% cases. Level of response to ESA treatment was independent of the degree of adherence to treatment.
Conclusions. Adherence to ESA treatment was good, without differences related to degree of response.
Downloads
References
CASES A, EGOCHEAGA MI, TRANCHEC S, PALLARÉS V, OJEDA R, GÓRRIZ JL, PORTOLÉS JM. Anemia en la enfermedad renal crónica: protocolo de estudio, manejo y derivación a Nefrología. Nefrología 2018; 3: 8-12. https://doi.org/10.1016/j.nefro.2017.09.004
GOROSTIDI M, SANTAMARÍA R, ALCÁZAR R, FERNÁNDEZ-FRESNEDO G, GALCERÁN JM, GOICOECHEA M et al. Documento de la Sociedad Española de Nefrología sobre las guías KDIGO para la evaluación y el tratamiento de la enfermedad renal crónica. Nefrología 2014; 34: 302-316. https://doi.org/10.3265/Nefrologia.pre2014.Feb.12464
LÓPEZ GÓMEZ JM. Manejo de la anemia en la enfermedad renal crónica. Nefrología 2008; 28: 63-66.
Ficha técnica de Aranesp®. Breda: Amgen Europe 2006. https://cima.aemps.es/cima/dochtml/ft/01185083/FT_01185083.html
Ficha técnica de Neorecormon®. Grenzach-Wyhlen: Roche Registration GmbH 2007. https://cima.aemps.es/cima/dochtml/ft/97031032/FT_97031032.html
JOHNSON DW, POLLOCK CA, MACDOUGALL IC. Erythropoiesis-stimulating agent hyporesponsiveness. Nephrology 2007; 12: 321-330. https://doi.org/10.1111/j.1440-1797.2007.00810.x
CHAN K, MORAN J, HLATKY M, LAFAYETTE R. Protocol adherence and the ability to achieve target haemoglobin levels in haemodialysis patients. Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc - Eur Ren Assoc. 2009 Jun;24(6):1956-1962. https://doi.org/10.1093/ndt/gfn780
LO WK. Latest strategy in renal anemia management in peritoneal dialysis patients. Perit Dial Int 2008; 28: S76-80.
RODRÍGUEZ-CHAMORRO MA, GARCÍA-JIMÉNEZ E, AMARILES P, RODRÍGUEZ-CHAMORRO A, FAUS MJ. Revisión de test de medición del cumplimiento terapéutico utilizados en la práctica clínica. Aten Primaria 2017; 49: 459-64. https://doi.org/10.1157/13125407
PAGÈS-PUIGDEMONT N, VALVERDE-MERINO MI. Métodos para medir la adherencia terapéutica. Ars Pharm 2018; 59: 163-172. http://doi.org/10.30827/ars.v59i3.7387.
Kidney Disease: Improving Global Outcomes (KDIGO) Anemia Work Group. KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Kidney Inter Suppl 2012; 2: 279-335. https://doi.org/10.1016/j.kisu.2017.10.001
YEAW J, BENNER JS, WALT JG, SIAN S, SMITH DB. Comparing adherence and persistence across 6 chronic medication classes. J Manag Care Pharm 2009; 15: 728-740. https://doi.org/10.18553/jmcp.2009.15.9.728
WAZNY LD, STOJIMIROVIC BB, HEIDENHEIM P, BLAKE PG. Factors influencing erythropoietin compliance in peritoneal dialysis patients. Am J Kidney Dis 2002; 40: 623-628. https://doi.org/10.1053/ajkd.2002.34925
ALBERO MOLINA MD, LÓPEZ-MENCHERO MARTÍNEZ R, DEL POZO FERNÁNDEZ C, ÁLVAREZ FERNÁNDEZ L, SÁNCHEZ RODRÍGUEZ L. Eficiencia de la administración mensual subcutánea de metoxi-polietilenglicol epoetina β (Mircera®) en pacientes estables en hemodiálisis previamente tratados con eritropoyetina semanal. Dial Traspl 2013; 34: 93-100. https://doi.org/10.1016/j.dialis.2012.08.005
ROSSERT J, LEVIN A, ROGER SD, HORL WH, ROUQUERAY B, GASSMANN-MAYER C, FREI D et al. Effect of early conrrection of anemia on the progression of CKD. Am J Kidney Dis 2006; 47: 738-750. https://doi.org/10.1053/j.ajkd.2006.02.170
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Anales del Sistema Sanitario de Navarra
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
La revista Anales del Sistema Sanitario de Navarra es publicada por el Departamento de Salud del Gobierno de Navarra (España), quien conserva los derechos patrimoniales (copyright ) sobre el artículo publicado y favorece y permite la difusión del mismo bajo licencia Creative Commons Reconocimiento-CompartirIgual 4.0 Internacional (CC BY-SA 4.0). Esta licencia permite copiar, usar, difundir, transmitir y exponer públicamente el artículo, siempre que siempre que se cite la autoría y la publicación inicial en Anales del Sistema Sanitario de Navarra, y se distinga la existencia de esta licencia de uso.
