Ophthalmic drugs during pregnancy

Authors

  • N. V. Arruti Vázquez
  • A. Rebollo Aguayo
  • G. Mezquita Gómez
  • A. Alcaine Soler
  • J. Andonegui Navarro

Keywords:

Ophthalmic drugs. Pregnancy. Fetal risk.

Abstract

The information available on the safety of medicines in pregnant women is limited and must be suitably channeled. Medication that is applied topically or as eye drops can present relevant systemic absorption and cross the placenta barrier or enter maternal milk.

We have reviewed ophthalmic medicines according to the fetal risk categories proposed by the classification of the Food and Drug Administration (FDA). We evaluate the medicines of choice in the most frequent ophthalmic pathologies, as well as the medicines that must be avoided.

Downloads

Download data is not yet available.

References

1. ABAD FJ, PONS J, MICÓ M, CASTERÁ DE, BELLÉS MD, SÁNCHEZ A. Categorías de riesgo de los medicamentos utilizados durante el embarazo: Guía rápida de consulta. FAP 2005; 3: 49-61.

2. YANG T, WALKER MC, KREWSKI D, YANG Q, NIMROD C, GARNER P et al. Maternal characteristics associated with pregnancy exposure to FDA category C, D and X drugs in a Canadian population. Pharmacoepidemiol Drug Saf 2008; 17: 270-277.

https://doi.org/10.1002/pds.1538

3. BARBERÁ E, VÁZQUEZ F. Tratamientos tópicos oculares: revisión. Inf Ter Sist Nac Salud 2009; 33: 80-87.

4. GIL MR, ORTEGA J, GIL MT, CORTÉS C. Farmacología ocular durante la gestación y la lactancia (I). Studium ophthalmologicum 2010; 28: 59-66.

5. DENIS D, TOUVRON G. Conduite à tenir chez une patiente présentant un glaucome pendant la grossesse. J Fr Ophtalmol 2010; 33: 346-349.

https://doi.org/10.1016/j.jfo.2010.03.007

6. RAZEGHINEJAD MR, TANIA TAI TY, FUDEMBERG SJ, KATZ LJ. Pregnancy and glaucoma. Surv Ophthalmol 2011; 56: 324-35.

https://doi.org/10.1016/j.survophthal.2010.11.008

7. WAGENVOORT A.M, VAN VUGT J.M.G, SOBOTKA M, VAN GEIJN H.P. Topical timolol therapy in pregnancy: is it safe for the fetus ? Teratology 1998; 58: 258-262.

https://doi.org/10.1002/(SICI)1096-9926(199812)58:6<258::AID-TERA7>3.0.CO;2-B

8. MADADI P, KOREN G, FREEMAN DJ, OERTEL R, CAMPBELL RJ, TROPE GE. Timolol concentrations in breast milk of a woman treated for glaucoma. Calculation of neonatal exposure. J Glaucoma 2008; 17: 329-331.

https://doi.org/10.1097/IJG.0b013e31815c3a5b

9. COPPENS G, STALMANS I, ZEYEN T. Glaucoma medication during pregnancy and nursing. Bull Soc Belge Ophtalmol 2010; 314: 33-36.

10. DING C, LU M, HUANG J. Changes of the ocular surface and aquaporins in the lacrimal glands of rabbits during pregnancy. Mol Vis 2011; 17: 2847-2855.

11. ESTEBAN E. Fármacos anti-VEGF (vascular endothelial growth factor). En: Arias L. Actualización de terapia anti-VEGF en enfermedades de la retina y coroides. Barcelona: Elsevier España, 2010: 1-5.

https://doi.org/10.1016/B978-84-8086-706-1.50001-8

12. GIL MR, ORTEGA J, GIL MT, CORTÉS C. Farmacología ocular durante la gestación y la lactancia (II). Studium ophthalmologicum 2010; 28: 121-128.

13. LÓPEZ MJ, SÁNCHEZ JI, SÁNCHEZ MC, CALDERAY M. Suplementos en embarazadas: controversias, evidencias y recomendaciones. Inf Ter Sist Nac Salud 2010; 34: 117-128.

14. LABETOULLE M, GENDRON G, OFFRET H. Les collyres chez l'enfant et la femme enceinte ou allaitante: quelles difficultés et pourquoi? J Fr Ophtalmol 2009; 32: 135-150.

https://doi.org/10.1016/j.jfo.2008.12.003

15. MILLODOT M. The influence of pregnancy on the sensitivity of the cornea. Br J Ophtalmol 1977; 61: 646-649.

https://doi.org/10.1136/bjo.61.10.646

16. WEINREB RN, LU A, BEESON C. Maternal corneal thickness during pregnancy. Am J Ophtalmol 1988; 105: 258-260.

https://doi.org/10.1016/0002-9394(88)90006-2

17. CHUNG CY, KWOK AKH, CHUNG KL. Use of ophthalmic medications during pregnancy. Hong Kong Med J 2004; 10: 191-195.

18. SHINOMIYA K, KAJIMA M, TAJIKA H, SHIOTA H, NAKAGAWA R, SAIJYOU T. Renal failure caused by eyedrops containing phenylephrine in a case of retinopathy of prematurity. J Med Invest 2003; 50: 203-206.

19. GASSET AR, AKABOSHI T. Embryopathic effect of ophthalmic EDTA. Invest Ophtalmol Vis Sci 1977; 16: 652-654.

Published

2014-01-09

How to Cite

1.
Arruti Vázquez NV, Rebollo Aguayo A, Mezquita Gómez G, Alcaine Soler A, Andonegui Navarro J. Ophthalmic drugs during pregnancy. An Sist Sanit Navar [Internet]. 2014 Jan. 9 [cited 2026 Feb. 10];36(3):479-87. Available from: https://recyt.fecyt.es/index.php/ASSN/article/view/20482

Issue

Section

Review article

Similar Articles

<< < 58 59 60 61 62 63 64 65 66 67 > >> 

You may also start an advanced similarity search for this article.