Effect of a strength training program on IGF-1 in older adults with obesity and controlled hypertension
DOI:
https://doi.org/10.47197/retos.v0i39.74723Keywords:
IGF-1, Seniors, Sarcopenia, TrainingAbstract
Abstract. Introduction: As people age, muscles decrease in size and strength. Loss of muscle mass can cause a general decrease of metabolic function associated with low anabolic hormone production and risk of injury. The decrease in serum levels of GH and IGF-1 due to aging can provoke fragility by contributing to the loss of muscle mass and strength. Purpose: To determine the effect of a strength training program on IGF-1 in older adults with obesity and controlled hypertension. Method: a sample of 8 older adults with obesity and controlled hypertension performed 6 weeks of strength training with intensities of 70% 1RM and 10RM, with a frequency of 4 times per week. Prior to the protocol of Training, triglycerides, cholesterol, blood glucose IGF-1, and anthropometric measures (size, weight, % fat and muscle mass) were determined. The test of one maximum repetition (1rm) was performed to evaluate maximum force in upper and lower limbs before and after the training program. Results: A significant increase (p <0.05) was observed in serum IGF-1 levels after the completion of training program. Conclusion: Strength training with intensities of 70% of 1RM and frequency of 4 days/week, carried out for 6 weeks, produced increases in serum IGF-1 concentration and increased muscle strength in older adults with obesity and controlled hypertension.
References
Berg, U., Salitin, B. y Hall, K, (1997). Net fluxes of IGF-1, IGFBP-1, insulin, GH and energy substrates over contracting muscle during prolonged exercise in healthy men. Endocrinoogy and Metabolism. 4, 313–320.
Berg, U. y Bang, P. (2014). Exercise and circulating insulin-like growth factor I. Hormone Researchs in Pediatrics. 62 (Suppl 1) 50–58.
Brown-Borg, H. M., Borg, K.E., Melsika, C.J., & Bartke. A. (1996). Dwarf mice and the ageing process. Nature, 384: 33.
Cadena Ortiz, L. M., Cornejo Martínez, S. J., Pinto, Q., Fabián, M., & Rueda Ochoa, O. L. (1998). Factor de crecimiento similar a la insulina: nuevos avances y perspectivas terapéuticas. MedUNAB, 1(3), 204-208.
Castro, L.E., Gálvez, A.Y., Guzmán, G.A., Garcia, A. (2019) Fuerza explosiva en adultas mayores, efectos del entrenamiento en fuerza máxima. RETOS, 36, 64-68.
Chen, H.-T., Chung, Y.-C., Chen, Y.-J., Ho, S.-Y., & Wu, H.-J. (2017). Effects of Different Types of Exercise on Body Composition, Muscle Strength, and IGF-1 in the Elderly with Sarcopenic Obesity. Journal of the American Geriatrics Society, 65(4), 827–832. doi:10.1111/jgs.14722.
Chicharro, J. L. & Mojares, L. M. L. (2008). Fisiología clínica del ejercicio. Ed. Médica Panamericana.
Da Costa, J. P., Vitorino, R., Silva, G. M., Vogel, C., Duarte, A. C., & Rocha-Santos, T. (2016). A synopsis on aging—Theories, mechanisms and future prospects. Ageing Research Reviews, 29, 90-112.
Drummond, M. J., Miyazaki, M., Dreyer, H. C., Pennings, B., Dhanani, S., Volpi, E., ... & Rasmussen, B. B. (2009). Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis. Journal of Applied Physiology, 106(4), 1403-1411.
Henwood, T.R., Riek, S., & Taaffe, D.R. (2008). Strength versus muscle power-specific resistance training in community-dwelling older adults. Journal of Gerontology. A Biol. Sci. Med. Sci. 63, 83–91.
Izquierdo, M., Hakkinen, K., Ibanez, J., Garrues, M., Anton, A., Zuniga, A., Larrion, J.L. y Gorostiaga, E.M. (2001). Effects of strength training on muscle power and serum hormones in middle-aged and older men. Journal of Applied Physiology. 90, 1497–1507.
Kraemer R.R. y Castracane, V.D. (2015). Endocrine alterations from concentric vs. eccentric muscle actions: a brief review. Metabolism, 64, 190–201.
Martinelli, C. Jr., Custodio, R.J. & Aguiar-Oliveira, M.E. (2008). Physiology of the GH-IGF axis. Arquivos Brasileiros de Endocrinologia & Metabologia, 52, 717–725.
Milman, S., Atzmon, G., Huffman, D.M., Wan, J., Crandall, J.P., Cohen, P. & Barzilai, N. (2014). Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity, Aging Cell, 13: 769-71. International Journal of Sports Medicine, 16: 445-450.
Nindl, B.C., Alemany, J.A., Kellogg, M.D., Rood, J., Allison, S.A., Young, A.J. & Montain S.J. (2007). Utility of circulating IGF-I as a biomarker for assessing body composition changes in men during periods of high physical activity superimposed upon energy and sleep restriction. Journal of Applied Physiology,103(1): 340–6.
Nindl, B.C. (2010). Insulin-like growth factor-I, physical activity, and control of cellular anabolism, Medicine & Science in Sports & Exercise, 42, 35–38.
Pereira, A., Izquierdo, M., Silva, A.J., Costa, A.M., Bastos, E., Gonzalez-Badillo, J.J., Marques, M.C. (2012a). Effects of high-speed power training on functional capacity and muscle performance in older women. Experimental Gerontology. 47, 250–255.
Pereira, A., Izquierdo, M., Silva, A.J., Costa, A.M., Gonzalez-Badillo, J.J., Marques, M.C., (2012b). Muscle performance and functional capacity retention in older women after high-speed power training cessation. Experimental Gerontology. 47, 620–624.
Roubenoff, R., Parise, H., Payette, H. A., Abad, L. W., D'Agostino, R., Jacques, P. F., ... & Harris, T. B. (2003). Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. The American Journal of Medicine, 115(6), 429-435.
Roberts, M. D., Dalbo, V. J., Sunderland, K. L., Poole, C. N., Hassell, S. E., Bemben, D., ... & Kerksick, C. M. (2010). IGF-1 splice variant and IGF-1 peptide expression patterns in young and old human skeletal muscle prior to and following sequential exercise bouts. European Journal of Applied Physiology, 110(5), 961-969.
Ramírez-Campillo, R., Castillo, A., de la Fuente, C.I., Campos-Jara, C., Andrade, D.C., Álvarez, C., … & Izquierdo, M. (2014). High-speed resistance training is more effective than low-speed resistance training to increase functional capacity and muscle performance in older women. Experimental Gerontology, 58, 51-57.
Sarsan, A., Ardiç, F., Özgen, M., Topuz, O., & Sermez, Y. (2006). The effects of aerobic and resistance exercises in obese women. Clinical Rehabilitation, 20(9), 773–782. doi:10.1177/0269215506070795
Seynnes, O., Fiatarone Singh, M. A., Hue, O., Pras, P., Legros, P., & Bernard, P. L. (2004). Physiological and functional responses to low-moderate versus high-intensity progressive resistance training in frail elders. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 59(5), M503-M509.
Stand, P. (2009). Progression models in resistance training for healthy adults. Medicine and Science in Sports and Exercise, 41(3), 687-708.
Schoenfeld, B. J., Ogborn, D., & Krieger, J. W. (2016). Effects of resistance training frequency on measures of muscle hypertrophy: a systematic review and meta-analysis. Sports Medicine, 46(11), 1689-1697.
Sung, J., Moon, J., Hyo, M. & Jin, S. (2017). Effect of low-intensity resistance training with heat stress on the HSP72, anabolic hormones, muscle size, and strength in elderly women. Aging Clinical and Experimental Research,29(5):977-984.
Trejo, M., Cisneros, F. J. D., Araujo, C. K., Cervantes, M. H. M., Garcidueñas, M. M. N., Guridi, R. C. A., & Espejel, H. A. P. (2018). Efecto del ejercicio máximo y submáximo sobre excreción de albúmina en adultos mayores. Retos: nuevas tendencias en educación física, deporte y recreación, (33), 238-240.
Van der Spoel, E., Rozing, M.P., Houwing-Duistermaat, J.J., Slagboom, P.E., Beekman, M., de Craen, A.J.M., … & van Heemst, D. (2015). Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study, Aging, 7, 956-63.
Weltman, A., Weltman, J.Y., Womack, C.J., Davis, S.E., Blumer, J.L., Gaesser, G.A. & Hartman, M.L. (1997). Exercise training decreases the growth hormone (GH) response to acute constant-load exercise. Medicine & Science in Sports & Exercise, 29, 669-676.
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