Long-term high-intensity interval training reduces blood glucose in type 2 diabetes mellitus patients
DOI:
https://doi.org/10.47197/retos.v60.109024Keywords:
Blood glucose, HIIT, insulin sensitivity, insulin resistance, type 2 diabetes patientsAbstract
This study aimed to demonstrate the long-term effects of high-intensity interval training (HIIT) on reducing blood glucose levels in patients with type 2 diabetes mellitus. The research employs a preexperimental design with a one-group pretest‒posttest design. A total of 20 patients with type 2 diabetes mellitus, aged 40–60 years, participated in the study and received the HIIT intervention three times per week for eight weeks. Data collection involved measuring fasting blood glucose levels before and after the HIIT intervention via the ONE TOUCH™ BASIC™ Plus Meter. Data analysis was conducted via paired sample t tests with a significance level of 5%, and the effect size was evaluated via Cohen's d. Paired sample t test analysis between pre-HIIT and post-HIIT blood glucose levels (181.50±17.85 mg/dL to 99.50±8.26 mg/dL, p ≤ 0.001) revealed a significant reduction, with a large effect size (Cohen's d = 5.896). This study confirms that long-term high-intensity interval training is effective in lowering fasting blood glucose levels to normal ranges in patients with type 2 diabetes mellitus.
Keywords: Blood glucose, HIIT, insulin sensitivity, insulin resistance, type 2 diabetes patients
References
Aispuru-Lanche, G. R., Gallego-Muñoz, M., Jayo-Montoya, J. A., Villar-Zabala, B., & Maldonado-Martín, S. (2023). Low-Volume and High-Intensity Aerobic Interval Training May Attenuate Dysfunctional Ventricular Remodeling after Myocardial Infarction: Data from the INTERFARCT Study. Reviews in cardiovascular medicine, 24(1), 20. https://doi.org/10.31083/j.rcm2401020.
Al-Rawaf, H. A., Gabr, S. A., Iqbal, A., & Alghadir, A. H. (2023). High-Intensity Interval Training Improves Glycemic Control, Cellular Apoptosis, and Oxidative Stress of Type 2 Diabetic Patients. Medicina (Kaunas, Lithuania), 59(7), 1320. https://doi.org/10.3390/medicina59071320.
Al-Sowayan, N. S., & Zakaria, R. (2022). High-Intensity Interval Training and Diabetes Mellitus. Journal of Biomedical Science and Engineering, 15(12), 281–286. https://doi.org/10.4236/jbise.2022.1512025.
Arroyave, F., Montaño, D., & Lizcano, F. (2020). Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells. International journal of molecular sciences, 21(22), 8685. https://doi.org/10.3390/ijms21228685.
Atakan, M. M., Li, Y., Koşar, Ş. N., Turnagöl, H. H., & Yan, X. (2021). Evidence-Based Effects of High-Intensity Interval Training on Exercise Capacity and Health: A Review with Historical Perspective. International Journal of Environmental Research and Public Health, 18(13). https://doi.org/10.3390/ijerph18137201.
Banday, M. Z., Sameer, A. S., & Nissar, S. (2020). Pathophysiology of diabetes: An overview. Avicenna journal of medicine, 10(4), 174–188. https://doi.org/10.4103/ajm.ajm_53_20.
Cai, Y., Long, Z., & Guo, Z. (2023). Effect of high-intensity interval training on body composition and glucose control in type 2 diabetes: A systematic review and meta-analysis. https://doi.org/10.1101/2023.01.27.23285090.
Callahan, M. J., Parr, E. B., Hawley, J. A., & Camera, D. M. (2021). Can High-Intensity Interval Training Promote Skeletal Muscle Anabolism?. Sports medicine (Auckland, N.Z.), 51(3), 405–421. https://doi.org/10.1007/s40279-020-01397-3.
Damaskos, C., Garmpis, N., Kollia, P., Mitsiopoulos, G., Barlampa, D., Drosos, A., Patsouras, A., Gravvanis, N., Antoniou, V., Litos, A., & Diamantis, E. (2020). Assessing Cardiovascular Risk in Patients with Diabetes: An Update. Current cardiology reviews, 16(4), 266–274. https://doi.org/10.2174/1573403X15666191111123622.
da Silva, D. E., Grande, A. J., Roever, L., Tse, G., Liu, T., Biondi-Zoccai, G., & de Farias, J. M. (2019). High-Intensity Interval Training in Patients with Type 2 Diabetes Mellitus: a Systematic Review. Current atherosclerosis reports, 21(2), 8. https://doi.org/10.1007/s11883-019-0767-9.
de Oliveira Teles, G., da Silva, C. S., Rezende, V. R., & Rebelo, A. C. S. (2022). Acute Effects of High-Intensity Interval Training on Diabetes Mellitus: A Systematic Review. International journal of environmental research and public health, 19(12), 7049. https://doi.org/10.3390/ijerph19127049.
Feng, J., Zhang, Q., Chen, B., Chen, J., Wang, W., Hu, Y., Yu, J., & Huang, H. (2024). Effects of high-intensity intermittent exercise on glucose and lipid metabolism in type 2 diabetes patients: A systematic review and meta-analysis. Frontiers in Endocrinology, 15, 1360998. https://doi.org/10.3389/fendo.2024.1360998.
Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K. B., Ostolaza, H., & Martín, C. (2020). Pathophysiology of Type 2 Diabetes Mellitus. International Journal of Molecular Sciences, 21(17), 6275. https://doi.org/10.3390/ijms21176275.
Islam, H., & Gillen, J. B. (2023). Skeletal muscle mechanisms contributing to improved glycemic control following intense interval exercise and training. Sports medicine and health science, 5(1), 20–28. https://doi.org/10.1016/j.smhs.2023.01.002.
Kanaley, J. A., Colberg, S. R., Corcoran, M. H., Malin, S. K., Rodriguez, N. R., Crespo, C. J., Kirwan, J. P., & Zierath, J. R. (2022). Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine. Medicine and Science in Sports and Exercise, 54(2), 353. https://doi.org/10.1249/MSS.0000000000002800.
Lazić, A., Stanković, D., Trajković, N., & Cadenas-Sanchez, C. (2024). Effects of HIIT Interventions on Cardiorespiratory Fitness and Glycemic Parameters in Adults with Type 1 Diabetes: A Systematic Review and Meta-Analysis. Sports medicine (Auckland, N.Z.), 10.1007/s40279-024-02059-4. Advance online publication. https://doi.org/10.1007/s40279-024-02059-4.
Liu, Y., Ye, W., Chen, Q., Zhang, Y., Kuo, C.-H., & Korivi, M. (2019). Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health, 16(1), 140. https://doi.org/10.3390/ijerph16010140.
Mateo-Gallego, R., Madinaveitia-Nisarre, L., Giné-Gonzalez, J., María Bea, A., Guerra-Torrecilla, L., Baila-Rueda, L., Perez-Calahorra, S., Civeira, F., & Lamiquiz-Moneo, I. (2022). The effects of high-intensity interval training on glucose metabolism, cardiorespiratory fitness and weight control in subjects with diabetes: Systematic review a meta-analysis. Diabetes research and clinical practice, 190, 109979. https://doi.org/10.1016/j.diabres.2022.109979.
Merz, K. E., & Thurmond, D. C. (2020). Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake. In R. Terjung (Ed.), Comprehensive Physiology (1st ed., pp. 785–809). Wiley. https://doi.org/10.1002/cphy.c190029.
Metcalfe, R., & Vollaard, N. (2024). Reduced-exertion high-intensity interval training (REHIT): a feasible approach for improving health and fitness?. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 49(7), 984–992. https://doi.org/10.1139/apnm-2024-0024.
Myers, J., Kokkinos, P., & Nyelin, E. (2019). Physical Activity, Cardiorespiratory Fitness, and the Metabolic Syndrome. Nutrients, 11(7), 1652. https://doi.org/10.3390/nu11071652.
Philis-Tsimikas, A., Chang, A., & Miller, L. (2011). Precision, accuracy, and user acceptance of the OneTouch SelectSimple blood glucose monitoring system. Journal of diabetes science and technology, 5(6), 1602–1609. https://doi.org/10.1177/193229681100500638.
Pranoto, A., Cahyono, M. B. A., Yakobus, R., Izzatunnisa, N., Ramadhan, R. N., Rejeki, P. S., Miftahussurur, M., Effendi, W. I., Wungu, C. D. K., & Yamaoka, Y. (2023). Long-Term Resistance-Endurance Combined Training Reduces Pro-Inflammatory Cytokines in Young Adult Females with Obesity. Sports (Basel, Switzerland), 11(3), 54. https://doi.org/10.3390/sports11030054.
Putera, S. H. P., Setijono, H., Wiriawan, O., Nurhasan, Muhammad, H. N., Hariyanto, A., Sholikhah, A. M., & Pranoto, A. (2023). Positive Effects of Plyometric Training on Increasing Speed, Strength and Limb Muscles Power in Adolescent Males. Physical Education Theory and Methodology, 23(1), 42–48. https://doi.org/10.17309/tmfv.2023.1.06.
Raharjo, S., Pranoto, A., Rejeki, P. S., Harisman, A. S. M., Pamungkas, Y. P., & Andiana, O. (2021). Negative Correlation between Serum Brain-derived Neurotrophic Factor Levels and Obesity Predictor Markers and Inflammation Levels in Females with Obesity. Open Access Macedonian Journal of Medical Sciences, 9(B), 1021–1026. https://doi.org/10.3889/oamjms.2021.6840.
Rejeki, P. S., Pranoto, A., Widiatmaja, D. M., Utami, D. M., Izzatunnisa, N., Sugiharto, Lesmana, R., & Halim, S. (2024). Combined Aerobic Exercise with Intermittent Fasting Is Effective for Reducing mTOR and Bcl-2 Levels in Obese Females. Sports (Basel, Switzerland), 12(5), 116. https://doi.org/10.3390/sports12050116.
Silva, L. R. B., Gentil, P., Seguro, C. S., De Oliveira, J. C. M., Silva, M. S., Marques, V. A., Beltrame, T., & Rebelo, A. C. S. (2022). High-Intensity Interval Training Improves Cardiac Autonomic Function in Patients with Type 2 Diabetes: A Randomized Controlled Trial. Biology, 11(1), 66. https://doi.org/10.3390/biology11010066.
Sullivan, G. M., & Feinn, R. (2012). Using Effect Size-or Why the P Value Is Not Enough. Journal of graduate medical education, 4(3), 279–282. https://doi.org/10.4300/JGME-D-12-00156.1.
Vertyshev, A. Yu., Akberdin, I. R., & Kolpakov, F. A. (2023). Numerous Trigger-like Interactions of Kinases/Protein Phosphatases in Human Skeletal Muscles Can Underlie Transient Processes in Activation of Signaling Pathways during Exercise. International Journal of Molecular Sciences, 24(13), 11223. https://doi.org/10.3390/ijms241311223.
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