Descifrando el papel del entrenamiento interválico de alta intensidad en el cáncer de mama: revisión sistemática (Deciphering the role of high-intensity interval training in breast cancer: systematic review)

Autores/as

  • Cristian González García Universidad de Murcia

DOI:

https://doi.org/10.47197/retos.v44i0.90566

Palabras clave:

cáncer, entrenamiento interválico de alta intensidad, mama., (cancer, high intensity interval training, breast)

Resumen

El cáncer de mama es uno de los más extendidos y proliferativo a nivel mundial. Esto provoca un gran impacto en el gasto sanitario. Aunque se sabe que el ejercicio físico mejora diferentes aspectos relacionados con el cáncer, hoy en día se desconoce qué tipo de entrenamiento o intensidad es mejor para esto. El propósito de esta revisión sistemática fue conocer los efectos fisiológicos, cognitivos y económicos que aporta el HIIT a este tipo de pacientes. La búsqueda se realizó en las bases de datos PubMed, Web of Science, MEDLINE y Scopus, a partir de los descriptores “cancer, high intensity interval training y breast”. De los 78 obtenidos inicialmente, 32 cumplieron todos los criterios de inclusión. Los estudios analizados se centran principalmente en añadir un programa HIIT al tratamiento de personas que padece, han padecido o tiene algo riesgo de padecerlo viendo efectos positivos a nivel de capacidades físicas, cognitivo y financiero. Este método es seguro y factible, y conlleva un aumento de la calidad de vida de estos pacientes. Además, puede mejorar las capacidades físicas, su calidad de vida, se reducen las tasas de finalización del tratamiento, hospitalización y gasto sanitario. Estos efectos beneficiosos deben ser tenidos en cuenta por los profesionales del ámbito médico, fisioterapeutas y profesionales en el deporte en cuanto a su implementación en estos pacientes.

Summary. Breast cancer is one of the most widespread and proliferative cancers worldwide. This has a great impact on healthcare spending. Although it is known that physical exercise improves different aspects related to cancer, it is currently unknown what type of training or intensity is best for this. The prupose of this systematic review was to find out the physiological, cognitive and economic effects of HIIT for this type of patient. The search was carried out in the databases PubMed, Web of Science, MEDLINE and Scopus, using the descriptors "cancer, high intensity interval training and breast". Of the 78 initially obtained, 32 met all the inclusion criteria. The studies analysed focus mainly on adding a HIIT programme to the treatment of people who suffer, have suffered or are at risk of suffering from cancer, seeing the positive effects on physical, cognitive and financial capacities. This method is safe and feasible, and leads to an increase in the quality of life of these patients. In addition, it can improve physical abilities and quality of life, reduce treatment completion rates, hospitalization and healthcare costs. Its implementation in cancer patients should be taken into account by professionals in the medical field, as well as physiotherapists and sports professionals, given its benefits.

Citas

Adamsen, L., Quist, M., Andersen, C., Moller, T., Herrstedt, J., Kronborg, D., Baadsgaard, M. T., Vistisen, K., Midtgaard, J., Christiansen, B., Stage, M., Kronborg, M. T., & Rorth, M. (2009). Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: Randomised controlled trial. Bmj-British Medical Journal, 339, b3410. https://doi.org/10.1136/bmj.b3410

Alizadeh, A. M., Isanejad, A., Sadighi, S., Mardani, M., kalaghchi, B., & Hassan, Z. M. (2019). High-intensity interval training can modulate the systemic inflammation and HSP70 in the breast cancer: A randomized control trial. Journal of Cancer Research and Clinical Oncology, 145(10), 2583-2593. https://doi.org/10.1007/s00432-019-02996-y

Alizadeh, S., Isanejad, A., Sadighi, S., Khalighfard, S., & Alizadeh, A. M. (2019). Effect of a high-intensity interval training on serum microRNA levels in women with breast cancer undergoing hormone therapy. A single-blind randomized trial. Annals of Physical and Rehabilitation Medicine, 62(5), 329-335. https://doi.org/10.1016/j.rehab.2019.07.001

Ansund, J., Mijwel, S., Bolam, K. A., Altena, R., Wengström, Y., Rullman, E., & Rundqvist, H. (2021). High intensity exercise during breast cancer chemotherapy—Effects on long-term myocardial damage and physical capacity—Data from the OptiTrain RCT. Cardio-Oncology, 7(1), 7. https://doi.org/10.1186/s40959-021-00091-1

Baldelli, G., De Santi, M., Gervasi, M., Annibalini, G., Sisti, D., Højman, P., Sestili, P., Stocchi, V., Barbieri, E., & Brandi, G. (2021). The effects of human sera conditioned by high-intensity exercise sessions and training on the tumorigenic potential of cancer cells. Clinical and Translational Oncology, 23(1), 22-34. https://doi.org/10.1007/s12094-020-02388-6

Bell, R. A., Baldi, J. C., & Jones, L. M. (2021). Additional cardiovascular fitness when progressing from moderate- to high-intensity exercise training in previously trained breast cancer survivors. Supportive Care in Cancer. https://doi.org/10.1007/s00520-021-06259-w

Bizjak, D. A., Schulz, S. V. W., Schumann, U., Otto, S., Kirsten, J., Ebner, F., Leinert, E., Huober, J., Janni, W., & Steinacker, J. M. (2020a). Beneficial Molecular Adaptations in BRCA-Mutation Carriers by Combined HIT/HIRT Intervention: Results from a Pilot Study. Cancers, 12(6), 1526. https://doi.org/10.3390/cancers12061526

Bizjak, D. A., Schulz, S. V. W., Schumann, U., Otto, S., Kirsten, J., Ebner, F., Leinert, E., Huober, J., Janni, W., & Steinacker, J. M. (2020b). Beneficial Molecular Adaptations In BRCA-Mutation Carriers By Combined HIT/HIRT Intervention: Results From A Pilot Study. Cancers, 12(6). https://doi.org/10.3390/cancers12061526

Blackwell, J. E. M., Doleman, B., Boereboom, C. L., Morton, A., Williams, S., Atherton, P., Smith, K., Williams, J. P., Phillips, B. E., & Lund, J. N. (2020). High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: A randomised control trial. Prostate Cancer and Prostatic Diseases. https://doi.org/10.1038/s41391-020-0219-1

Bolam, K. A., Mijwel, S., Rundqvist, H., & Wengström, Y. (2019). Two-year follow-up of the OptiTrain randomised controlled exercise trial. Breast Cancer Research and Treatment, 175(3), 637-648. https://doi.org/10.1007/s10549-019-05204-0

Chung, W.-P., Yang, H.-L., Hsu, Y.-T., Hung, C.-H., Liu, P.-Y., Liu, Y.-W., Chan, S.-H., & Tsai, K.-L. (2021). Real-time exercise reduces impaired cardiac function in breast cancer patients undergoing chemotherapy: A randomized controlled trial. Annals of Physical and Rehabilitation Medicine, 3, 101485. https://doi.org/10.1016/j.rehab.2021.101485

Coletta, A. M., Agha, N. H., Baker, F. L., Niemiro, G. M., Mylabathula, P. L., Brewster, A. M., Bevers, T. B., Fuentes-Mattei, E., Basen-Engquist, K., Gilchrist, S. C., & Simpson, R. J. (2021). The impact of high-intensity interval exercise training on NK-cell function and circulating myokines for breast cancer prevention among women at high risk for breast cancer. Breast Cancer Research and Treatment, 187(2), 407-416. https://doi.org/10.1007/s10549-021-06111-z

Coletta, A. M., Brewster, A. M., Chen, M., Li, Y., Bevers, T. B., Basen-Engquist, K., & Gilchrist, S. C. (2019). High-Intensity Interval Training Is Feasible in Women at High Risk for Breast Cancer: Medicine & Science in Sports & Exercise, 51(11), 2193-2200. https://doi.org/10.1249/MSS.0000000000002048

D’Ascenzi, F., Anselmi, F., Fiorentini, C., Mannucci, R., Bonifazi, M., & Mondillo, S. (2019). The benefits of exercise in cancer patients and the criteria for exercise prescription in cardio-oncology. European Journal of Preventive Cardiology, 204748731987490. https://doi.org/10.1177/2047487319874900

Dennett, A. M., Peiris, C. L., Shields, N., Prendergast, L. A., & Taylor, N. F. (2016). Moderate-intensity exercise reduces fatigue and improves mobility in cancer survivors: A systematic review and meta-regression. Journal of Physiotherapy, 62(2), 68-82. https://doi.org/10.1016/j.jphys.2016.02.012

Emberts, T., Porcari, J., Dobers-tein, S., Steffen, J., & Foster, C. (2013). Exercise Intensity and Energy Expenditure of a Tabata Workout. Journal of Sports Science & Medicine, 12(3), 612-613.

Foerster, B., Pozo, C., Abufaraj, M., Mari, A., Kimura, S., D’Andrea, D., John, H., & Shariat, S. F. (2018). Association of Smoking Status With Recurrence, Metastasis, and Mortality Among Patients With Localized Prostate Cancer Undergoing Prostatectomy or Radiotherapy: A Systematic Review and Meta-analysis. JAMA Oncology, 4(7), 953-961. https://doi.org/10.1001/jamaoncol.2018.1071

Forouzanfar, M. H., Afshin, A., Alexander, L. T., Anderson, H. R., Bhutta, Z. A., Biryukov, S., Brauer, M., Burnett, R., Cercy, K., Charlson, F. J., Cohen, A. J., Dandona, L., Estep, K., Ferrari, A. J., Frostad, J. J., Fullman, N., Gething, P. W., Godwin, W. W., Griswold, M., … Murray, C. J. L. (2016). Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: A systematic analysis for the Global Burden of Disease Study 2015. The Lancet, 388(10053), 1659-1724. https://doi.org/10.1016/S0140-6736(16)31679-8

Fuller, J. T., Hartland, M. C., Maloney, L. T., & Davison, K. (2018). Therapeutic effects of aerobic and resistance exercises for cancer survivors: A systematic review of meta-analyses of clinical trials. British Journal of Sports Medicine, 52(20), 1311-1311. https://doi.org/10.1136/bjsports-2017-098285

García, A. M. de O., Manzanedo, J. G., & González, J. G. P. (2019). Entrenamiento Interválico de Alta Intensidad (HIIT) como herramienta terapéutica en pacientes con Diabetes Mellitus Tipo 2: Una revisión narrativa. Retos, 36, 633-639. https://doi.org/10.47197/retos.v36i36.69762

Gibala, M. J., & McGee, S. L. (2008). Metabolic Adaptations to Short-term High-Intensity Interval Training: A Little Pain for a Lot of Gain? Exercise and Sport Sciences Reviews, 36(2), 58-63. https://doi.org/10.1097/JES.0b013e318168ec1f

Gomez Piqueras, P., & Sanchez Gonzalez, M. (2019). High Intensity Interval Training (hiit) in Older Adults: A Systematic Review. Pensar En Movimiento-Revista De Ciencias Del Ejercicio Y La Salud, 17(1), UNSP e35494. https://doi.org/10.15517/pensarmov.v17i1.35494

Grisalez, A. A. D., Quiceno, C. A. M., Herrera, A. L. C., & Corrales, J. L. H. (2021). Efecto de un programa de entrenamiento interválico aeróbico de alta intensidad en población escolar femenina con sobrepeso u obesidad (Effect of a high intensity aerobic interval training program on an overweight or obese female school population). Retos, 39, 453-458. https://doi.org/10.47197/retos.v0i39.78200

Heinrich, K. M., Patel, P. M., O’Neal, J. L., & Heinrich, B. S. (2014). High-intensity compared to moderate-intensity training for exercise initiation, enjoyment, adherence, and intentions: An intervention study. Bmc Public Health, 14, 789. https://doi.org/10.1186/1471-2458-14-789

Hiensch, A. E., Mijwel, S., Bargiela, D., Wengström, Y., May, A. M., & Rundqvist, H. (2021). Inflammation Mediates Exercise Effects on Fatigue in Patients with Breast Cancer. Medicine & Science in Sports & Exercise, 53(3), 496-504. https://doi.org/10.1249/MSS.0000000000002490

Karlsen, T., Aamot, I.-L., Haykowsky, M., & Rognmo, Ø. (2017). High Intensity Interval Training for Maximizing Health Outcomes. Progress in Cardiovascular Diseases, 60(1), 67-77. https://doi.org/10.1016/j.pcad.2017.03.006

Lee, K., Kang, I., Mack, W. J., Mortimer, J., Sattler, F., Salem, G., & Dieli-Conwright, C. M. (2019). Feasibility of high intensity interval training in patients with breast Cancer undergoing anthracycline chemotherapy: A randomized pilot trial. BMC Cancer, 19(1), 653. https://doi.org/10.1186/s12885-019-5887-7

Lee, K., Kang, I., Mack, W. J., Mortimer, J., Sattler, F., Salem, G., Lu, J., & Dieli-Conwright, C. M. (2019). Effects of high-intensity interval training on vascular endothelial function and vascular wall thickness in breast cancer patients receiving anthracycline-based chemotherapy: A randomized pilot study. Breast Cancer Research and Treatment, 177(2), 477-485. https://doi.org/10.1007/s10549-019-05332-7

Lee, K., Norris, M. K., Wang, E., & Dieli-Conwright, C. M. (2021). Effect of high-intensity interval training on patient-reported outcomes and physical function in women with breast cancer receiving anthracycline-based chemotherapy. Supportive Care in Cancer. https://doi.org/10.1007/s00520-021-06294-7

Lee, K., Ortiz, K., Goytizolo, J., Serrano, T., & Dieli-Conwright, C. M. (2020). Abstract D033: High-intensity interval training is feasible in Hispanic patients with breast cancer undergoing anthracycline chemotherapy. Cancer Epidemiology and Prevention Biomarkers, 29(6 Supplement 2), D033.

Midtgaard, J., Christensen, J. F., Tolver, A., Jones, L. W., Uth, J., Rasmussen, B., Tang, L., Adamsen, L., & Rorth, M. (2013). Efficacy of multimodal exercise-based rehabilitation on physical activity, cardiorespiratory fitness, and patient-reported outcomes in cancer survivors: A randomized, controlled trial. Annals of Oncology, 24(9), 2267-2273. https://doi.org/10.1093/annonc/mdt185

Mijwel, S., Backman, M., Bolam, K. A., Jervaeus, A., Sundberg, C. J., Margolin, S., Browall, M., Rundqvist, H., & Wengström, Y. (2018). Adding high-intensity interval training to conventional training modalities: Optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial. Breast Cancer Research and Treatment, 168(1), 79-93. https://doi.org/10.1007/s10549-017-4571-3

Mijwel, S., Backman, M., Bolam, K. A., Olofsson, E., Norrbom, J., Bergh, J., Sundberg, C. J., Wengström, Y., & Rundqvist, H. (2018). Highly favorable physiological responses to concurrent resistance and high-intensity interval training during chemotherapy: The OptiTrain breast cancer trial. Breast Cancer Research and Treatment, 169(1), 93-103. https://doi.org/10.1007/s10549-018-4663-8

Mijwel, S., Bolam, K. A., Gerrevall, J., Foukakis, T., Wengström, Y., & Rundqvist, H. (2020). Effects of Exercise on Chemotherapy Completion and Hospitalization Rates: The OptiTrain Breast Cancer Trial. The Oncologist, 25(1), 23-32. https://doi.org/10.1634/theoncologist.2019-0262

Mijwel, S., Bolam, K. A., Wengstrom, Y., & Rundqvist, H. (2019). Effects Of Exercise During Chemotherapy On Hospitalization And Chemotherapy Completion: The OptiTrain Breast Cancer Trial. Medicine and Science in Sports and Exercise, 51(6), 881-881. https://doi.org/10.1249/01.mss.0000563131.82247.a8

Mijwel, S., Cardinale, D. A., Norrbom, J., Chapman, M., Ivarsson, N., Wengström, Y., Sundberg, C. J., & Rundqvist, H. (2018). Exercise training during chemotherapy preserves skeletal muscle fiber area, capillarization, and mitochondrial content in patients with breast cancer. The FASEB Journal, 32(10), 5495-5505. https://doi.org/10.1096/fj.201700968R

Mijwel, S., Jervaeus, A., Bolam, K. A., Norrbom, J., Bergh, J., Rundqvist, H., & Wengström, Y. (2019). High-intensity exercise during chemotherapy induces beneficial effects 12 months into breast cancer survivorship. Journal of Cancer Survivorship, 13(2), 244-256. https://doi.org/10.1007/s11764-019-00747-z

Neto, V. G. C., Rosário, J. A. do, Bodell, N., Araujo, G. da S., Telles, L. G. da S., Freitas, J. P. de, Colonna, M. J. C. M., Triani, F. da S., Silva, R. S. da, & Monteiro, E. R. (2022). Blood pressure, heart rate, and rate pressure product behavior during interval and continuous aerobic exercise (Comportamiento de la presión arterial, frecuencia cardíaca y doble producto durante el ejercicio aeróbico a intervalos y continuo). Retos, 43, 579-585. https://doi.org/10.47197/retos.v43i0.88363

Northey, J. M., Pumpa, K. L., Quinlan, C., Ikin, A., Toohey, K., Smee, D. J., & Rattray, B. (2019). Cognition in breast cancer survivors: A pilot study of interval and continuous exercise. Journal of Science and Medicine in Sport, 22(5), 580-585. https://doi.org/10.1016/j.jsams.2018.11.026

Pagola, I., Morales, J. S., Alejo, L. B., Barcelo, O., Montil, M., Olivan, J., Alvarez-Bustos, A., Cantos, B., Maximiano, C., Hidalgo, F., Valenzuela, P. L., Fiuza-Luces, C., Lucia, A., & Ruiz-Casado, A. (2020). Concurrent Exercise Interventions in Breast Cancer Survivors with Cancer-related Fatigue. International Journal of Sports Medicine, 41(11), 790-797. https://doi.org/10.1055/a-1147-1513

Pérez, F. J. S., & Chaves, G. A. C. (2015). Efectos del entrenamiento Tabata en la composición corporal del futbolista. Kronos: revista universitaria de la actividad física y el deporte, 14(1), 7.

Plummer, M., de Martel, C., Vignat, J., Ferlay, J., Bray, F., & Franceschi, S. (2016). Global burden of cancers attributable to infections in 2012: A synthetic analysis. The Lancet. Global Health, 4(9), e609-616. https://doi.org/10.1016/S2214-109X(16)30143-7

Reljic, D., Lampe, D., Wolf, F., Zopf, Y., Herrmann, H. J., & Fischer, J. (2019). Prevalence and predictors of dropout from high-intensity interval training in sedentary individuals: A meta-analysis. Scandinavian Journal of Medicine & Science in Sports, 29(9), 1288-1304. https://doi.org/10.1111/sms.13452

Schlüter, K., Schneider, J., Sprave, T., Wiskemann, J., & Rosenberger, F. (2019). Feasibility of Two High-Intensity Interval Training Protocols in Cancer Survivors. Medicine and Science in Sports and Exercise, 51(12), 2443-2450. https://doi.org/10.1249/MSS.0000000000002081

Schmitt, J., Lindner, N., Reuss-Borst, M., Holmberg, H.-C., & Sperlich, B. (2016a). A 3-week multimodal intervention involving high-intensity interval training in female cancer survivors: A randomized controlled trial. Physiological Reports, 4(3), e12693. https://doi.org/10.14814/phy2.12693

Schmitt, J., Lindner, N., Reuss-Borst, M., Holmberg, H.-C., & Sperlich, B. (2016b). A 3-week multimodal intervention involving high-intensity interval training in female cancer survivors: A randomized controlled trial. Physiological Reports, 4(3), e12693. https://doi.org/10.14814/phy2.12693

Schulz, S. V. W., Laszlo, R., Otto, S., Prokopchuk, D., Schumann, U., Ebner, F., Huober, J., & Steinacker, J. M. (2018). Feasibility and effects of a combined adjuvant high-intensity interval/strength training in breast cancer patients: A single-center pilot study. Disability and Rehabilitation, 40(13), 1501-1508. https://doi.org/10.1080/09638288.2017.1300688

Schulz, S. V. W., Schumann, U., Otto, S., Kirsten, J., Treff, G., Janni, W., Huober, J., Leinert, E., Steinacker, J. M., & Bizjak, D. A. (2021). Two-year follow-up after a six-week high-intensity training intervention study with breast cancer patients: Physiological, psychological and immunological differences. Disability and Rehabilitation, 0(0), 1-8. https://doi.org/10.1080/09638288.2021.1921861

Segovia, Y., & Gutiérrez, D. (2020). Esfuerzo, Implicación y Condición Física percibida en un Programa HIIT en Educación Física. Modelo Educación Deportiva vs Metodología Tradicional (Perception of Exertion, involvement and physical fitness in a HIIT Program in Physical Education. Sport Edu. Retos, 38, 151-158. https://doi.org/10.47197/retos.v38i38.73686

Toohey, K., Pumpa, K., McKune, A., Cooke, J., Welvaert, M., Northey, J., Quinlan, C., & Semple, S. (2020). The impact of high-intensity interval training exercise on breast cancer survivors: A pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems. BMC cancer, 20(1), 787. https://doi.org/10.1186/s12885-020-07295-1

Wang, E., Lee, K., & Dieli-Conwright, C. M. (2019). Effects of High-Intensity Interval Training on Body Composition in Breast Cancer Patients Undergoing Anthracycline Chemotherapy. Medicine and Science in Sports and Exercise, 51(6), 879-879. https://doi.org/10.1249/01.mss.0000563126.07797.6d

Wiggenraad, F., Bolam, K. A., Mijwel, S., van der Wall, E., Wengström, Y., & Altena, R. (2020). Long-Term Favorable Effects of Physical Exercise on Burdensome Symptoms in the OptiTrain Breast Cancer Randomized Controlled Trial. Integrative Cancer Therapies, 19, 1534735420905003. https://doi.org/10.1177/1534735420905003

Wilke, J., Kaiser, S., Niederer, D., Kalo, K., Engeroff, T., Morath, C., Vogt, L., & Banzer, W. (2019). Effects of high-intensity functional circuit training on motor function and sport motivation in healthy, inactive adults. Scandinavian Journal of Medicine & Science in Sports, 29(1), 144-153. https://doi.org/10.1111/sms.13313

Zhang, X., Li, Y., & Liu, D. (2019). Effects of exercise on the quality of life in breast cancer patients: A systematic review of randomized controlled trials. Supportive Care in Cancer, 27(1), 9-21. https://doi.org/10.1007/s00520-018-4363-2

Descargas

Publicado

2022-04-01

Cómo citar

García, C. G. (2022). Descifrando el papel del entrenamiento interválico de alta intensidad en el cáncer de mama: revisión sistemática (Deciphering the role of high-intensity interval training in breast cancer: systematic review). Retos, 44, 136–145. https://doi.org/10.47197/retos.v44i0.90566

Número

Sección

Revisiones teóricas, sistemáticas y/o metaanálisis