Genetic and soccer: association of ACTN3 and ACE-I/D genetic polymorphisms in soccer players: Literary review
DOI:
https://doi.org/10.47197/retos.v0i39.79347Keywords:
ACE I/D, ACTN3 R577X, sports genetics, performance, polymorphismAbstract
Abstract. It has been verified and established that around 66% of the components of the athlete's performance and state are explained by hereditary factors. Two of the most studied genetic polymorphisms in relation to sports performance in the last decade are ACTN3 R577X and ACE I/D. The aim of this study was to summarize the possible associations of both polymorphisms and the performance in soccer players, determining the allelic and genotypic combination that stands out the most in this population and, also, to observe their relationships at the physical and physiological level. In order to complete this study, two phases were carried out, the first one of literature review and, the second one which covered the information classification and analysis. The studies show a greater influence of the ACE-D and ACTN-R alleles, and higher presence of the ACE-ID and ACTN-RR genotypes. Subjects with these combinations were found to perform better on speed and strength tests. On the other hand, the ACTN3 polymorphism is directly related to muscle injuries. In conclusion, a relationship between genetic polymorphisms and performance in soccer players could be observed. Genetic components can be integrated as a new component within the characterization of sport and as a tool within a model of identification and detection of talents in youth soccer. In addition, genetic biomarkers could be responsible, in the future, for the study of the risk of injury so that performance in professional soccer is much more optimized.
References
Ahmetov, I., & Fedotovskaya, O. (2015). Current Progress in Sports Genomics. Advances in Clinical Chemistry, 70, 247-314. doi:10.1016/bs.acc.2015.03.003.
Alvarez, R., Terrado, N., Ortolano, R., Iglesia-Cubero, G., Reguero, J., Batalla, A., . . . Coto, E. (2000). Genetic variation in the renin-angiotensin system and athletic performance. European Journal of Applied Physiology, 82(1-2), 117–120. doi:10.1007/s004210050660
Arroyo-Moya, W., Rodríguez-Buitrago, A., & Escarria-Moreno, A. (2020). La nueva frontera de la preparación deportiva, la genética y el polimorfismo ACE I/D en atletas de resistencia. Revista Digital: Actividad Física y Deporte, 6(2), 100-117. doi:10.31910/rdafd.v6.n2.2020.1571
Bangsbo, J. (1994). Energy demands in competitive soccer. Journal of Sports Sciences, 12, S5- S12. doi:https://doi.org/10.1080/02640414.1994.12059272
Bouchard, C., Rankinen, T., & Timmons, J. (2011). Genomics and Genetics in the Biology of Adaptation to Exercise. Comprehensive Physiology, 1(3), 1603-1648. doi:10.1002/cphy.c100059
Canali, E., & Kruel, L. (2001). Respostas hormonais ao exercício. Rev. paul. Educ. Fís., São Paulo 15 (2), 141-153.
Caratachea, M. (2007). Polimorfismos genéticos: Importancia y aplicaciones. Revista del Instituto Nacional de Enfermedades Respiratorias, 20(3), 213-221.
Cięszczyk, P., Leońska-Duniec, A., Maciejewska-Skrendo, A., Sawczuk, M., Leźnicka, K., Contrò, V., . . . Lulińska-Kuklik. (2016). Variation in the ACE gene in elite Polish football players. Human Movement, 17(4), 237-241. doi:https://doi.org/10.1515/humo-2016-0032
Clos, E., Pruna, R., Lundblad, M., Artells, R., & Esquirol-Caussa, J. (2019). ACTN3 single nucleotide polymorphism is associated with non-contact musculoskeletal soft-tissue injury incidence in elite professional football players. Knee Surg Sports Traumatol Arthrosc, 27(12), 4055-4061. doi:10.1007/s00167-019-05381-x
Coelho, D., Pimenta, E., Cruz, I., Veneroso, C., Pussieldi, G., Becker, L., . . . Silami-Garcia, E. (2016 a). Angiotensin-converting enzyme (ACE-I/D) polymorphism frequency in Brazilian soccer players. Applied Physiology, Nutrition and Metabolism, 41(6), 692- 694. doi:10.1139/apnm-2015-0514
Coelho, D., Pimenta, E., Rosse, I., de Castro, B., Becker, L., de Oliveira, E., . . . Garcia, E. (2018 ). Evidence for a Role of ACTN3 R577X Polymorphism in Football Player's Career Progression. International Journal of Sports Medicine, 39(14), 1088-1093. doi:10.1055/a-0753-4973
Coelho, D., Pimenta, E., Rosse, I., Veneroso, C., Pussieldi, G., Becker, L., . . . Silami-Garcia, E. (2019). Alpha-Actinin-3 R577X Polymorphism Influences Muscle Damage and Hormonal Responses After a Soccer Game. Journal of Strength & Conditioning Research, 33(10), 2655-2664. doi:10.1519/JSC.0000000000002575
Coelho, D., Pimienta, E., Rosse, I., Veneroso, C., Becker, L., Carvalho, M., . . . Silami-Garcia, E. (2016 b). The alpha-actinin-3 R577X polymorphism and physical performance in soccer players. Journal of Sports Medicine and Physical Fitness, 56(3), 241-248. Obtenido de https://pubmed.ncbi.nlm.nih.gov/25650734/
Copelli, S. (2010). Genética : desde la herencia a la manipulación de los genes. Buenos Aires: Fundación de Historia Natural Félix de Azara.
Costa, A., Silva, A., Garrido, N., Louro, H., De Oliveira, R., & Breitenfeld, L. (2009). Association between ACE D allele and elite short distance swimming. European Journal of Applied Physiology , 106(6), 785-790. doi:10.1007/s00421-009-1080-z
De Moor, M., Spector, T., Cherkas, L., Falchi, M., Hottenga, J., Boomsma, I., & De Geus, E. (2007). Genome–wide linkage scan for athlete status in 700 British female DZ twin pairs. Twin Research and Human Genetics, 10(6), 812–820. doi:10.1375/twin.10.6.812
Derbré, Vincent, Maitel, Jacob, Delamarche, Delamarche, & Zouhal. (2010). Androgen responses to sprint exercise in young men. International Journal of Sports Medicine, 31(5), 291-297. doi:10.1055/s-0030-1248243
Dionísio, T., Thiengo, C., Brozoski, D., Dionísio, E, Talamoni, G., . . . Amaral, S. (2017). The influence of genetic polymorphisms on performance, cardiac and hemodynamic parameters among Brazilian soccer players. Applied Physiology, Nutrition and Metabolism, 42(6), 596-604. doi:https://doi.org/10.1139/apnm-2016-0608
Egorova, E., Borisova, A., Mustafina, L., Arkhipova, A., Gabbasov, R., Druzhevskaya, A., . . . Ahmetov, I. (2014). The polygenic profile of Russian football players. Journal of Sports Sciences, 32(13), 1286–1293. doi:10.1080/02640414.2014.898853
Ehlert, T., Simon, P., & Moser, D. (2013). Epigenetics in Sports. Sports Medicine, 43, 93-110. doi:10.1007/s40279-012-0012-y
Eider, J., Cieszczyk, P., Ficek, K., Leonska-Duniec, A., Sawczuk, M., Maciejewska-Karlowska, A., & Zarebska, A. (2013). The association between D allele of the ACE gene and power performance in Polish elite athletes. Science & Sports, 28(6), 325-330. doi:10.1016/j.scispo.2012.11.005
Fischer, C. (2006). Interleukin-6 in acute exercise and training:What is the biological relevance? Exercise Immunology Review, 12, 6–33. Obtenido de https://www.ncbi.nlm.nih.gov/pubmed/17201070
Galeandro, V., Notarnicola, A., Bianco, A., Tafuri, S., Russo, L., Pesce, V., . . . Petruzzella, V. (2017). ACTN3/ACE genotypes and mitochondrial genome in professional soccer players performance. J Biol Regul Homeost Agents, 31(1), 207-213. Obtenido de https://europepmc.org/article/med/28337894
García-Robles, R., Ayala-Ramírez, P., & Perdomo-Velásquez, S. (2012). Epigenética: definición, bases moleculares e implicaciones en la salud y en la evolución humana. Revista Ciencia y Salud, 10(1), 59-71.
Honarpour, A., Mohseni, M., Hajiagha, S., Irani, S., & Najmabadi. (2017). Investigation of the Relationship Between a Genetic Polymorphism in ACTN3 and Elite Sport Performance Among Iranian Soccer Players. Iranian Rehabilitation Journal, 15(2), 149-154. doi:10.18869/nrip.irj.15.2.149
Jones, A., Montgomery, H., & Woods, D. (2002). Human Performance: A Role for the ACE Genotype? Exercise and Sport Sciences Reviews, 30(4), 184-190. Obtenido de https://journals.lww.comx
Kikuchi, N., & Nakazato, K. (2015). Effective utilization of genetic information for athletes and coaches: focus on ACTN3 R577X polymorphism. Journal of Exercise Nutrition & Biochemistry, 19(3), 157–164. doi:10.5717/jenb.2015.15093001
Lee, F., Houweling, P., North, K., & Quinlan, K. (2016). How does α-actinin-3 deficiency alter muscle function? Mechanistic insights into ACTN3, the ‘gene for speed’. Biochimica et Biophysica Acta , 1863(4), 686–693. doi:10.1016/j.bbamcr.2016.01.013
Massidda, M., Voisin, S., Culigioni, C., Piras, F., Cugia, P., Yan, X., . . . Calò, C. (2019). ACTN3 R577X Polymorphism Is Associated With the Incidence and Severity of Injuries in Professional Football Players. Clinical Journal of Sport Medicine, 29(1), 57–61. doi:10.1097/JSM.0000000000000487
Mills, M., Yang, N., Weinberger, R., Vander-Woude, D., Beggs, A., Easteal, S., & North, K. (2001). Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy. Human Molecular Genetics, 10(13), 1335-1346. doi:10.1093/hmg/10.13.1335
Moya, D., Madrigal, J., & Zalasar, L. (2012). Angiotensin Converting Enzyme Insertion/Deletion Polymorphism and its Association with Complications in Patients with type 2 Diabetes Mellitus. Acta Médica Costarricense, 54(2), 102-108.
Muniesa, C., Santiago, C., Gómez-Gallego, F., & Lucía, A. (2011). Genética y Deporte. Madrid: Consejo Superior de Deportes. Obtenido de https://sede.educacion.gob.es/publiventa/genetica-y-deporte/ciencias-del-deporte/14554
NHGRI. (s.f). https://www.genome.gov. Obtenido de https://www.genome.gov/es/genetics-glossary
Ozveren, Y., Ozcaldiran, B., Durmaz, B., & Oral, O. (2014). Talent selection and genetics in sport. Turkish Journal of Sport and Exercise, 16(2), 1-8. doi:10.15314/TJSE.201428098
Padullés i Riu, J. M., Terrados, N., Rodas, G., & Campos, N. (2004). Genética y deporte. FORO J. M. CAGIGAL. Apunts. Educación física y deportes, 77, 85-87.
Papadimitriou, I., Papadopoulos, C., Kouvatsi, A., & Triantaphyllidis, C. (2008). The ACTN3 gene in elite greek track and field athletes. International Journal of Sports Medicine, 29(4), 352-355. doi:10.1055/s-2007-965339
Pimenta, Coelho, Cruz, Morandi, Veneroso, Pussieldi, d. A., . . . Fernández, D. P. (2012). The ACTN3 genotype in soccer players in response to acute eccentric training. European Journal of Applied Physiology, 112(4), 1495-1503. doi:10.1007/s00421-011-2109-7
Pimenta, E., Coelho, D., Veneroso, C., Barros Coelho, E., Cruz, I., Morandi, R., . . . De Paz Fernández, J. (2013). Effect of ACTN3 Gene on Strength and Endurance in Soccer Players. Journal of Strength and Conditioning Research, 27(12), 3286-3292. doi:10.1519/JSC.0b013e3182915e66
Puthucheary, Z., Skipworth, J., Rawal, J., Loosemore, M., Van Someren, K., & Montgomery, H. (2011). The ACE Gene and Human Performance 12 Years On. Sports Medicine, 41(6), 433-448. doi:10.2165/11588720-000000000-00000
Rattigan, S., Dora, K., Tong, A., & Clark, M. (1996). Perfused skeletal muscle contraction and metabolism improved by angiotensin II-mediated vasoconstriction. American Journal of Physiology, 271(1), 96-103. doi:10.1152/ajpendo.1996.271.1.E96
Reilly, T., Bangsbo, J., & Franks, A. (2000). Anthropometric and physiological predispositions for elite soccer. Journal of Sports Sciences, 18(9), 669-683. doi:10.1080/02640410050120050
Sánchez, J., Campuzano, Ó., Iglesias, A., & Brugada, R. (2009). Genética y Deporte. Apunts Sports Medicine, 44(162), 86-97.
Santiago, C., Rodríguez‐Romo, Gómez‐Gallego, F., González‐Freire, M., Yvert, T., Verde, F., . . . Lucia, A. (2010). Is there an association between ACTN3 R577X polymorphism and muscle power phenotypes in young, non‐athletic adults? Scandinavian Journal of Medicine & Science in Sports, 20(5), 771-778. doi:10.1111/j.1600-0838.2009.01017.x
Serra-Olivares, J., Prieto-Ayuso, A., Pastor-Vicedo, J., & González-Víllora, S. (2020). Propuesta de evaluación multidisciplinar del talento de jóvenes futbolistas. Retos: Nuevas Tendencias en Educación Física, Deporte y Recreación, 38, 782-789.
Seto, J., Monkol, L., Quinlan, K., Houweling, P., Zheng, X., Garton, F., . . . North, K. (2011). Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling. Human Molecular Genetics, 20(15), 2914–2927. doi:10.1093/hmg/ddr196
Sgourou, S., Fotopoulos, V., Kontos, V., Patrinos, G., & Papachatzopoulou, A. (2012). Association of genome variations in the reninangiotensin system with physical performance. Human Genomics, 6(1), 6-24. doi:10.1186/1479-7364-6-24
Stølen, T., Chamari, K., Castagna, C., & Wisløff, U. (2005). Physiology of Soccer. An Update. Sports Medicine, 35(6), 501-536. doi:10.2165/00007256-200535060-00004
Suraci, B., Quigley, C., Thelwell, R., & Milligan, G. (2019). A Comparison of Training Modality and Total Genotype Scores to Enhance Sport-Specific Biomotor Abilities in Under 19 Male Soccer Players. The Journal of Strength & Conditioning Research, [published online ahead of print, 2019 Nov 27]. doi:10.1519/JSC.0000000000003299
Ulucan, K., Sercan, K., & Biyikli, T. (2015). Distribution of Angiotensin-1 Converting Enzyme Insertion/Deletion and α-Actinin-3 Codon 577 Polymorphisms in Turkish Male Soccer Players. Genetics & Epigenetics, 7, 1- 4. doi:10.4137/GEG.S31479
Unnithan, V., White, J., Georgiou, A., Iga, J., & Drust, B. (2012). Talent identification in youth soccer. Journal of Sports Sciences, 30(15), 1719–1726. doi:10.1080/02640414.2012.731515
Williams, A., & Reilly, T. (2000). Talent identification and development in soccer. Journal of Sports Sciences, 18(9), 657–667. doi:10.1080/02640410050120041
Woods, D., Hickmann, M., Jamshidi, Y., Brull, D., Vassiliou, V., Jones, A., . . . Montgomery, H. (2001). Elite swimmers and the D allele of the ACE I/D polymorphism. Human Genetics , 108(3), 230–232. doi:10.1007/s004390100466
Yang, N., MacArthur, D., Gulbin, J., Hahn, A., Beggs, A., Easteal, S., & North, K. (2003). ACTN3 Genotype Is Associated with Human Elite Athletic Performance. American journal of human genetics, 73(3), 627–631. doi:10.1086/377590
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Wilson Arroyo Moya
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and ensure the magazine the right to be the first publication of the work as licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of authorship of the work and the initial publication in this magazine.
- Authors can establish separate additional agreements for non-exclusive distribution of the version of the work published in the journal (eg, to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Is allowed and authors are encouraged to disseminate their work electronically (eg, in institutional repositories or on their own website) prior to and during the submission process, as it can lead to productive exchanges, as well as to a subpoena more Early and more of published work (See The Effect of Open Access) (in English).
This journal provides immediate open access to its content (BOAI, http://legacy.earlham.edu/~peters/fos/boaifaq.htm#openaccess) on the principle that making research freely available to the public supports a greater global exchange of knowledge. The authors may download the papers from the journal website, or will be provided with the PDF version of the article via e-mail.