Association between exercise training and açai on calcium homeostasis and inflammation in the heart of rats submitted to a high-fat diet

Authors

  • Victor Neiva Lavorato Department of Physical Education, Governador Ozanam Coelho University Center (UNIFAGOC), Ubá, Minas Gerais, Brazil. https://orcid.org/0000-0001-9914-4722
  • Denise Coutinho de Miranda Department of Physical Education, Governador Ozanam Coelho University Center (UNIFAGOC), Ubá, Minas Gerais, Brazil. https://orcid.org/0000-0001-8714-6309
  • Luciano Bernardes Leite Department of Physical Education, Laboratory of Exercise Biology Federal University of Viçosa, Viçosa, Brazil
  • Marcelo Eustáquio Silva School of Nutrition, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil
  • Antônio José Natali Department of Physical Education, Laboratory of Exercise Biology Federal University of Viçosa, Viçosa, Brazil https://orcid.org/0000-0002-4927-4024

DOI:

https://doi.org/10.47197/retos.v55.103103

Keywords:

Exercise training; Açai; Contractility; Inflammation; Heart.

Abstract

The aim of the present study was to investigate the effects of the association of treatments with aerobic exercise training (AET) and açai supplementation on calcium homeostasis (Ca2+) and inflammatory markers of the heart of rats submitted to a high-fat diet. Fisher rats were used, divided into five experimental groups: Control (C), High-fat Diet (H); High-fat Diet + Açai (HA); High-fat Diet + AET (HT); High-fat Diet + Açai + AET (HAT). The groups fed a high-fat diet received 21.8% lard and 1% cholesterol. The groups supplemented with lyophilized açai received 1% of açai in the diet. The animals in the trained groups were submitted to a progressive treadmill running program for 8 weeks. At the end, the hearts were dissected, and the left ventricles separated for real-time PCR analysis. The HT group had higher gene expression of ryanodine receptor type 2 (RyR2) compared to group H. Regarding the sodium/calcium exchanger (NCX), group H had lower gene expression compared to the other groups. Interleukin 10 (IL-10) was high in group HT when compared to group H. The treatments changed parameters of Ca2+ homeostasis and inflammation, but the association of interventions did not provide additional effects.

Keywords: Exercise training; Açai; Contractility; Inflammation; Heart.

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Published

2024-04-02

How to Cite

Neiva Lavorato, V. ., Coutinho de Miranda, D. ., Bernardes Leite , L., Eustáquio Silva, M. ., & José Natali, A. (2024). Association between exercise training and açai on calcium homeostasis and inflammation in the heart of rats submitted to a high-fat diet. Retos, 55, 302–306. https://doi.org/10.47197/retos.v55.103103

Issue

Vol. 55 (2024)

Section

Original Research Article

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