New pharmaceutical dosage forms for allergy treatment
Keywords:
Inmunoterapia. Alergia. Nanopartículas. Micropartículas.Abstract
Specific immunotherapy involves certain drawbacks which could be minimized by the use of appropriate adjuvants, capable of amplifying the right immune response with minimal side effects. In this context, we review different types of immunotherapy vehicles and coadyuvants. We describe previous studies by our group in which we demonstrated the adjuvant capacity of Gantrez® AN nanoparticles, which can effectively enhance the immune response. We employed two types of nanoparticles (with and without LPS of Brucella ovis as immunomodulator) within capsulated ovoalbumin and Lollium perenne extract, tested on a model of mice sensitized to this allergenic mixture. In the challenge experiment involving the sensitized mice, differences in the mortality rate and in the MCP-1 levels were found between the treated groups and the control. Under the experimental conditions of this model of mice pre-sensitized to L. perenne, Gantrez®AN nanoparticles appeared to be a good strategy for immunotherapy. We finally tested these carriers administered by the oral route and found that they were able to protect a model of mice sensitized to ovalbumin from anaphylactic shock.Downloads
References
1. KUSCHNER WG. The asthma epidemic. N Engl J Med 2007; 356: 1073.
https://doi.org/10.1056/NEJMc063596
2. ASHER MI, MONTEFORT S, BJORKSTEN B, LAI CK, STRACHAN DP, WEILAND SK et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006; 368: 733-743.
https://doi.org/10.1016/S0140-6736(06)69283-0
3. FERNANDEZ RIVAS M. Food allergy in Alergologica-2005. J Investig Allergol Clin Immunol 2009; 19 (Suppl. 2): 37-44.
4. NAVARRO A, COLAS C, ANTON E, CONDE J, DAVILA I, DORDAL MT et al. Epidemiology of allergic rhinitis in allergy consultations in Spain: Alergologica-2005. J Investig Allergol Clin Immunol 2009; 19 (Suppl. 2): 7-13.
5. RADULOVIC SCM, WILSON D, DURHAM S. Sublingual immunotherapy for allergic rhinitis. Cochrane Database Syst Rev 2010; CD002893.
https://doi.org/10.1002/14651858.CD002893.pub2
6. CALDERON MA AB, JACOBSON M, HURWITZ B, SHEIKH A, DURHAM S. Allergen injection immunotherapy for seasonal allergic rhinitis. Cochrane Database Syst Rev 2007; CD001936.
https://doi.org/10.1002/14651858.CD007163
7. TSITOURA DC, TASSIOS Y. Immunomodulation: the future cure for allergic diseases. Ann N Y Acad Sci 2006; 1088: 100-115.
https://doi.org/10.1196/annals.1366.026
8. FONSECA DE KJ. Use of CpG oligonucleotides in treatment of asthma and allergic disease. Adv Drug Deliv Rev. 2009; 61: 256-262.
https://doi.org/10.1016/j.addr.2008.12.007
9. SHEIKH NA, AL-SHAMISI M, MORROW WJ. Delivery systems for molecular vaccination. Curr Opin Mol Ther 2000; 2: 37-54.
10. CLEMENTS CJ, GRIFFITHS E. The global impact of vaccines containing aluminium adjuvants. Vaccine 2002; 20 (Suppl. 3): S24-S33.
https://doi.org/10.1016/S0264-410X(02)00168-8
11. FRANCIS MJ, FRY CM, ROWLANDS DJ, BITTLE JL, HOUGHTEN RA, LERNER RA et al. Immune response to uncoupled peptides of foot-and-mouth disease virus. Immunology 1987; 61: 1-6.
12. KWISSA M, LINDBLAD EB, SCHIRMBECK R, REIMANN J. Codelivery of a DNA vaccine and a protein vaccine with aluminum phosphate stimulates a potent and multivalent immune response. J Mol Med (Berl) 2003; 81: 502-510.
https://doi.org/10.1007/s00109-003-0452-9
13. SCHIJNS V E. Immunological concepts of vaccine adjuvant activity. Curr Opin Immunol 2000; 12: 456-63.
https://doi.org/10.1016/S0952-7915(00)00120-5
14. O'HAGAN DT, VALIANTE NM. Recent advances in the discovery and delivery of vaccine adjuvants. Nat Rev Drug Discov 2003; 2: 727-735.
https://doi.org/10.1038/nrd1176
15. KERSTEN G, HIRSCHBERG H. Antigen delivery systems. Expert Rev Vaccines 2004; 3: 453-462.
https://doi.org/10.1586/14760584.3.4.453
16. ULMER JB. Enhancement of vaccine potency through improved delivery. Expert Opin Biol Ther 2004; 4: 1045-1051.
https://doi.org/10.1517/14712598.4.7.1045
17. CALDERON MA, PENAGOS M, SHEIKH A, CANONICA GW, DURHAM S. Sublingual immunotherapy for treating allergic conjunctivitis. Cochrane Database Syst Rev 2011; CD007685.
https://doi.org/10.1002/14651858.CD007685.pub2
18. RADULOVIC S, WILSON D, CALDERON M, DURHAM S. Systematic reviews of sublingual immunotherapy (SLIT). Allergy 2011; 66: 740-752.
https://doi.org/10.1111/j.1398-9995.2011.02583.x
19. ENRIQUE E, PINEDA F, MALEK T, BARTRA J, BASAGANA M, TELLA R et al. Sublingual immunotherapy for hazelnut food allergy: a randomized, double-blind, placebo-controlled study with a standardized hazelnut extract. J Allergy Clin Immunol 2005; 116: 1073-1079.
https://doi.org/10.1016/j.jaci.2005.08.027
20. FERNÁNDEZ-RIVAS M, GARRIDO FERNANDEZ S, NADAL JA, DIAZ DE DURANA MD, GARCÍA BE, GONZALEZ-MANCEBO E et al. Randomized double-blind, placebo-controlled trial of sublingual immunotherapy with a Pru p 3 quantified peach extract. Allergy 2009; 64: 876-883.
https://doi.org/10.1111/j.1398-9995.2008.01921.x
21. GÓMEZ S, GAMAZO C, SAN ROMÁN B, VAUTHIER C, FERRER M, IRACHE JM. Developement of a novel vaccine delivery system based on Gantrez nanoparticles. J Nanosci Nanotechnol 2006; 6: 3283-3289.
https://doi.org/10.1166/jnn.2006.471
22. RICE-FICHT AC, ARENAS-GAMBOA AM, KAHL-MCDONAGH MM, FICHT TA. Polymeric particles in vaccine delivery. Curr Opin Microbiol 2010; 13: 106-112.
https://doi.org/10.1016/j.mib.2009.12.001
23. CHADWICK S, KRIEGEL C, AMIJI M. Nanotechnology solutions for mucosal immunization. Adv Drug Deliv Rev 2010; 62: 394-407.
https://doi.org/10.1016/j.addr.2009.11.012
24. ZOLNIK BS, GONZALEZ-FERNANDEZ A, SADRIEH N, DOBROVOLSKAIA MA. Nanoparticles and the immune system. Endocrinology 2010; 151: 458-465.
https://doi.org/10.1210/en.2009-1082
25. WILSON KD, DE JONG SD, TAM YK. Lipid-based delivery of CpG oligonucleotides enhances immunotherapeutic efficacy. Adv Drug Deliv Rev 2009; 61: 233-242.
https://doi.org/10.1016/j.addr.2008.12.014
26. ALTIN JG, PARISH CR. Liposomal vaccines--targeting the delivery of antigen. Methods 2006; 40: 39-52.
https://doi.org/10.1016/j.ymeth.2006.05.027
27. DOW S. Liposome-nucleic acid immunotherapeutics. Expert Opin Drug Deliv 2008; 5: 11-24.
https://doi.org/10.1517/17425247.5.1.11
28. TOVEY MG, LALLEMAND C. Adjuvant activity of cytokines. Methods Mol Biol 2010; 626: 287-309.
https://doi.org/10.1007/978-1-60761-585-9_19
29. GAMVRELLIS A, LEONG D, HANLEY JC, XIANG SD, MOTTRAM P, PLEBANSKI M. Vaccines that facilitate antigen entry into dendritic cells. Immunol Cell Biol 2004; 82: 506-516.
https://doi.org/10.1111/j.0818-9641.2004.01271.x
30. SINGH M, CHAKRAPANI A, O'HAGAN D. Nanoparticles and microparticles as vaccine-delivery systems. Expert Rev Vaccines 2007; 6: 797-808.
https://doi.org/10.1586/14760584.6.5.797
31. SCHOLL I, WEISSENBOCK A, FORSTER-WALDL E, UNTERSMAYR E, WALTER F, WILLHEIM M et al. Allergen-loaded biodegradable poly (D,L-lactic-co-glycolic) acid nanoparticles down-regulate an ongoing Th2 response in the BALB/c mouse model. Clin Exp Allergy 2004; 34: 315-321.
https://doi.org/10.1111/j.1365-2222.2004.01884.x
32. BATANERO E, BARRAL P, VILLALBA M, RODRÍGUEZ R. Encapsulation of Ole e 1 in biodegradable microparticles induces Th1 response in mice: a potential vaccine for allergy. J Control Release 2003; 92: 395-398.
https://doi.org/10.1016/S0168-3659(03)00337-7
33. ROPERT C, MALVY C, COUVREUR P. Inhibition of the Friend retrovirus by antisense oligonucleotides encapsulated in liposomes: mechanism of action. Pharm Res 1993; 10: 1427-1433.
https://doi.org/10.1023/A:1018910922633
34. O'HAGAN DT, RAPPUOLI R. Novel approaches to vaccine delivery. Pharm Res 2004; 21: 1519-1530.
https://doi.org/10.1023/B:PHAM.0000041443.17935.33
35. SINGH M, O'HAGAN D T. Recent advances in vaccine adjuvants. Pharm Res 2002; 19: 715-728.
https://doi.org/10.1023/A:1016104910582
36. ALVAREZ MJ, ECHECHIPIA S, GARCIA B, TABAR AI, MARTIN S, RICO P et al. Liposome-entrapped D. pteronyssinus vaccination in mild asthma patients: effect of 1-year double-blind, placebo-controlled trial on inflammation, bronchial hyperresponsiveness and immediate and late bronchial responses to the allergen. Clin Exp Allergy 2002; 32: 1574-1582.
https://doi.org/10.1046/j.1365-2222.2002.01514.x
37. BASOMBA A, TABAR AI, DE ROJAS DH, GARCIA BE, ALAMAR R, OLAGUIBEL J M et al. Allergen vaccination with a liposome-encapsulated extract of Dermatophagoides pteronyssinus: a randomized, double-blind, placebo-controlled trial in asthmatic patients. J Allergy Clin Immunol 2002; 109: 943-948.
https://doi.org/10.1067/mai.2002.124465
38. SPENLEHAUER G, SPENLEHAUER-BONTHONNEAU F, THIES C. Biodegradable microparticles for delivery of polypeptides and proteins. Prog Clin Biol Res 1989; 292: 283-291.
39. ARBOS P, WIRTH M, ARANGOA M A, GABOR F, IRACHE J M. Gantrez AN as a new polymer for the preparation of ligand-nanoparticle conjugates. J Control Release 2002; 83: 321-330.
https://doi.org/10.1016/S0168-3659(02)00015-9
40. SAN ROMAN B, IRACHE JM, GOMEZ S, GAMAZO C, ESPUELAS S. Co-Delivery of Ovalbumin and CpG motifs into microparticles protected sensitized mice from anaphylaxis. Int Arch Allergy Immuno 2009; 149: 111-118.
https://doi.org/10.1159/000189193
41. SAN ROMAN B, IRACHE JM, GOMEZ S, TSAPIS N, GAMAZO C, ESPUELAS MS. Co-encapsulation of an antigen and CpG oligonucleotides into PLGA microparticles by TROMS technology. Eur J Pharm Biopharm 2008; 70: 98-108.
https://doi.org/10.1016/j.ejpb.2008.03.015
42. GÓMEZ S, GAMAZO C, ROMAN BS, FERRER M, SANZ ML, IRACHE JM. Gantrez AN nanoparticles as an adjuvant for oral immunotherapy with allergens. Vaccine 2007; 25: 5263-5271.
https://doi.org/10.1016/j.vaccine.2007.05.020
43. GÓMEZ S, GAMAZO C, SAN ROMAN B, GRAU A, ESPUELAS S, FERRER M ET AL. A novel nanoparticulate adjuvant for immunotherapy with Lolium perenne. J Immunol Methods 2009; 348: 1-8.
https://doi.org/10.1016/j.jim.2009.06.005
44. LACK G. Clinical practice. Food allergy. N Engl J Med 2008; 359: 1252-1260.
https://doi.org/10.1056/NEJMcp0800871
45. DE SILVA IL, MEHR SS, TEY D, TANG ML. Paediatric anaphylaxis: a 5 year retrospective review. Allergy 2008; 63: 1071-1076.
https://doi.org/10.1111/j.1398-9995.2008.01719.x
46. CLARK AT, ISLAM S, KING Y, DEIGHTON J, ANAGNOSTOU K, EWAN PW. Successful oral tolerance induction in severe peanut allergy. Allergy 2009; 64: 1218-1220.
https://doi.org/10.1111/j.1398-9995.2009.01982.x
47. SHEIKH A, NURMATOV U, VENDERBOSCH I, BISCHOFF E. Oral immunotherapy for the treatment of peanut allergy: systematic review of six case series studies. Prim Care Respir J 2011; doi:10.4104/pcrj.2011.00071. [Epub ahead of print]
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