El eosinófilo: ¿"sigue siendo el rey"?

1. GLEICH GJ. Mechanisms of eosinophil-associated inflammation. J Allergy Clin Immunol 2000; 105:651-663.

https://doi.org/10.1067/mai.2000.105712

2. FOSTER PS. Allergic networks regulating eosinophilia. Am J Respir Cell Mol Biol 1999; 21: 451-454.

https://doi.org/10.1165/ajrcmb.21.4.f167

3. SHI HZ, XIAO CQ, ZHONG D, QIN SM, LIU Y, LIANG GR et al. Effect of inhaled interleukin-5 on airway hyperreactivity and eosinophilia in asthmatics. Am J Respir Crit Care Med 1998; 157: 204-209.

https://doi.org/10.1164/ajrccm.157.1.9703027

4. HUMBERT M, CORRIGAN CJ, KIMMITT P, TILL SJ, KAY AB, DURHAM SR. Relationship between IL-4 and IL-5 mRNA expression and disease severity in atopic asthma. Am J Respir Crit Care Med 1997; 156:704-708.

https://doi.org/10.1164/ajrccm.156.3.9610033

5. BUSSE WW, LEMANSKE RF, JR. Asthma. N Engl J Med 2001; 344: 350-362.

https://doi.org/10.1056/NEJM200102013440507

6. HOLGATE ST. The inflammation-repair cycle in asthma: the pivotal role of the airway epithelium. Clin Exp Allergy 1998; 28 Suppl 5: 97-103.

https://doi.org/10.1046/j.1365-2222.1998.028s5097.x

7. WALSH GM, SEXTON DW, BLAYLOCK MG, CONVERY CM. Resting and cytokine-stimulated human small airway epithelial cells recognize and engulf apoptotic eosinophils. Blood 1999; 94: 2827-2835.

https://doi.org/10.1182/blood.V94.8.2827.420a04_2827_2835

8. WALSH GM. Eosinophil-epithelial cell interactions: a special relationship? Clin Exp Allergy 2001; 31: 351-354.

https://doi.org/10.1046/j.1365-2222.2001.01032.x

9. FORRESTER DL, KNOX AJ. Airway smooth muscle: telling the eosinophil how to behave. Clin Exp Allergy 2009; 39: 938-939.

https://doi.org/10.1111/j.1365-2222.2009.03282.x

10. LECKIE MJ, TEN BRINKE A, KHAN J, DIAMANT Z, O'CONNOR BJ, WALLS CM et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000; 356: 2144-2148.

https://doi.org/10.1016/S0140-6736(00)03496-6

11. FLOOD-PAGE P, SWENSON C, FAIFERMAN I, MATTHEWS J, WILLIAMS M, BRANNICK L et al. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med 2007; 176: 1062-1071.

https://doi.org/10.1164/rccm.200701-085OC

12. O'BYRNE PM, INMAN MD, PARAMESWARAN K. The trials and tribulations of IL-5, eosinophils, and allergic asthma. J Allergy Clin Immunol 2001; 108: 503-508.

https://doi.org/10.1067/mai.2001.119149

13. WENZEL SE, SCHWARTZ LB, LANGMACK EL, HALLIDAY JL, TRUDEAU JB, GIBBS RL et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999; 160: 1001-1008.

https://doi.org/10.1164/ajrccm.160.3.9812110

14. HALDAR P, PAVORD ID, SHAW DE, BERRY MA, THOMAS M, BRIGHTLING CE et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008; 178: 218-224.

https://doi.org/10.1164/rccm.200711-1754OC

15. MIRANDA C, BUSACKER A, BALZAR S, TRUDEAU J, WENZEL SE. Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation. J Allergy Clin Immunol 2004; 113: 101-108.

https://doi.org/10.1016/j.jaci.2003.10.041

16. GREEN RH, BRIGHTLING CE, MCKENNA S, HARGADON B, PARKER D, BRADDING P et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 2002; 360: 1715-1721.

https://doi.org/10.1016/S0140-6736(02)11679-5

17. HALDAR P, BRIGHTLING CE, HARGADON B, GUPTA S, MONTEIRO W, SOUSA A et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009; 360: 973-984.

https://doi.org/10.1056/NEJMoa0808991

18. NAIR P, PIZZICHINI MM, KJARSGAARD M, INMAN MD, EFTHIMIADIS A, PIZZICHINI E et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009; 360: 985-993.

https://doi.org/10.1056/NEJMoa0805435

19. ROTHENBERG ME. Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol 2004; 113: 11-28; quiz 9.

https://doi.org/10.1016/j.jaci.2003.10.047

20. GARRETT JK, JAMESON SC, THOMSON B, COLLINS MH, WAGONER LE, FREESE DK et al. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol 2004; 113: 115-119.

https://doi.org/10.1016/j.jaci.2003.10.049

21. ARORA AS, YAMAZAKI K. Eosinophilic esophagitis: asthma of the esophagus? Clin Gastroenterol Hepatol 2004; 2: 523-530.

https://doi.org/10.1016/S1542-3565(04)00236-8