Safety considerations during prescription of non-steroidal anti-inflammatory drugs (NSAIDs), through a review of systematic reviews
DOI:
https://doi.org/10.23938/ASSN.0965Keywords:
NSAIDs, Cardiovascular disease, Hypertension, Umbrella review.Abstract
Los medicamentos antiinflamatorios no esteroideos (AINEs) se encuentran entre los medicamentos más consumidos mundialmente. Esto hace necesario realizar una síntesis amplia de la evidencia disponible sobre la prescripción segura y adecuada de AINEs en pacientes con enfermedad cardiovascular, enfermedad renal crónica, hipertensión, insuficiencia cardíaca o cirrosis hepática y en población general. Para ello se ha realizado una revisión de revisiones sistemáticas. El uso de AINEs se asoció a una probabilidad significativamente mayor de hepatotoxicidad y daño renal y un mayor riesgo de exacerbación de la insuficiencia cardíaca. Teniendo en cuenta el aumento del riesgo cardiovascular, hepático y renal, la prescripción de AINEs debe realizarse con cautela, considerando la duración del tratamiento y la situación del paciente. Por ello, se debe informar a los pacientes sobre sus posibles consecuencias para la salud así como garantizar un seguimiento adecuado de los mismos.
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