Revisión sobre el uso del metilfenidato para el tratamiento de la astenia en pacientes paliativos.

Autores/as

  • A. Saralegui
  • P. Palacio
  • P. Royo

Palabras clave:

"metilfenidato". "fatiga". "astenia relacionada con cancer". "pacientes paliativos". "cancer".

Resumen

La astenia o fatiga, es uno de los síntomas mas frecuentes en el paciente paliativo. Uno de los tratamientos mas empleados para combatir la misma es el metilfenidato. Se realizó una revisión de la bibliografía publicada hasta la fecha sobre su manejo, hallándose, que, el metilfenidato es un fármaco seguro que, globalmente, puede reducir la fatiga en el paciente paliativo, con un perfil de efectos secundarios tolerable.

Descargas

Los datos de descargas todavía no están disponibles.

Citas

1. RADBRUCH L, STRASSER F, ELSNER F, GONÇALVES JF, LØGE J, KAASA S, NAUCK F, STONE P. Research steering committee of the European Association for Palliative Care (EAPC). Fatigue in palliative care patients -- an EAPC approach. Palliat Med 2008; 22: 13-32.

https://doi.org/10.1177/0269216307085183

2. MINTON O, RICHARDSON A, SHARPE M, HOTOPF M, STONE P.A systematic review and meta-analysis of the pharmacological treatment of cancer-related fatigue. J Natl Cancer Inst 2008 20; 100: 1155-1166.

https://doi.org/10.1093/jnci/djn250

3. PEUCKMANN V, ELSNER F, KRUMM N, TROTTENBERG P, RADBRUCH L. Pharmacological treatments for fatigue associated with palliative care. Cochrane Database Syst Rev 2010; (11): CD006788.

4. PORTELA MA, RUBIALES AS, CENTENO C. The use of psychostimulants in cancer patients. Curr Opin Support Palliat Care 2011; 5: 164-168.

https://doi.org/10.1097/SPC.0b013e3283462ff3

5. SOOD A, BARTON DL, LOPRINZI CL. Use of methylphenidate in patients with cancer. Am J Hosp Palliat Care 2006; 23: 35-40.

https://doi.org/10.1177/104990910602300106

6. HARRIS JD. Fatigue in chronically ill patients. Curr Opin Support Palliat Care 2008; 2: 180-186.

https://doi.org/10.1097/SPC.0b013e32830baed0

7. BREITBART W, ALICI Y. Pharmacologic treatment options for cancer-related fatigue: current state of clinical research. Clin J Oncol Nurs 2008; 12 (5 Suppl): 27-36.

https://doi.org/10.1188/08.CJON.S2.27-36

8. HARDY SE. Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults. Am J Geriatr Pharmacother 2009; 7: 34-59.

https://doi.org/10.1016/j.amjopharm.2009.02.006

9. ROTH AJ, NELSON C, ROSENFELD B, SCHER H, SLOVIN S, MORRIS M et al. Methylphenidate for fatigue in ambulatory men with prostate cancer. Cancer 2010; 116: 5102-5110.

https://doi.org/10.1002/cncr.25424

10. WAGNER GJ, RABKIN JG, RABKIN R. Dextroamphetamine as a treatment for depression and low energy in AIDS patients: a pilot study. J Psychosom Res 1997; 42: 407-411.

https://doi.org/10.1016/S0022-3999(96)00366-2

11. BRUERA E, VALERO V, DRIVER L, SHEN L, WILLEY J, ZHANG T et al. Patient-controlled methylphenidate for cancer fatigue: a double-blind, randomized, placebo-controlled trial. J Clin Oncol 2006; 24: 2073-2078.

https://doi.org/10.1200/JCO.2005.02.8506

12. BUTLER JM JR, CASE LD, ATKINS J, FRIZZELL B, SANDERS G, GRIFFIN P et al. A phase III, double-blind, placebo-controlled prospective randomized clinical trial of d-threo-methylphenidate HCl in brain tumor patients receiving radiation therapy. Int J Radiat Oncol Biol Phys 2007; 69: 1496-1501.

https://doi.org/10.1016/j.ijrobp.2007.05.076

13. AURET KA, SCHUG SA, BREMNER AP, BULSARA M. A randomized, double-blind, placebo-controlled trial assessing the impact of dexamphetamine on fatigue in patients with advanced cancer. J Pain Symptom Manage 2009; 37: 613-621.

https://doi.org/10.1016/j.jpainsymman.2008.03.016

14. MINTON O, RICHARDSON A, SHARPE M, HOTOPF M, STONE PC. Psychostimulants for the management of cancer-related fatigue: a systematic review and meta-analysis. J Pain Symptom Manage 2011; 41: 761-767.

https://doi.org/10.1016/j.jpainsymman.2010.06.020

15. LOWER EE, FLEISHMAN S, COOPER A, ZELDIS J, FALECK H, YU Z et al. Efficacy of dexmethylphenidate for the treatment of fatigue after cancer chemotherapy: a randomized clinical trial. J Pain Symptom Manage. 2009; 38: 650-662.

https://doi.org/10.1016/j.jpainsymman.2009.03.011

16. MORASKA AR, SOOD A, DAKHIL SR, SLOAN JA, BARTON D, ATHERTON PJ et al. Phase III, randomized, double-blind, placebo-controlled study of long-acting methylphenidate for cancer-related fatigue: North Central Cancer Treatment Group NCCTG-N05C7 trial. J Clin Oncol 2010; 28: 3673-3679.

https://doi.org/10.1200/JCO.2010.28.1444

17. LAVAL G, PARIS A. [Methylphenidate in palliative care in cancer patient: a double-blind randomised trial versus placebo]. Bull Cancer 2008; 95: 241-246.

18. LASHEEN W, WALSH D, MAHMOUD F, DAVIS MP, RIVERA N, KHOSHKNABI DS. Methylphenidate side effects in advanced cancer: a retrospective analysis. Am J Hosp Palliat Care 2010; 27: 16-23.

https://doi.org/10.1177/1049909109345145

19. CUEVA JF, CALVO M, ANIDO U, LEÓN L, GALLARDO E, ARESES C et al. Methylphenidate in the management of asthenia in breast cancer patients treated with docetaxel: results of a pilot study. Invest New Drugs 2012; 30: 688-694.

https://doi.org/10.1007/s10637-010-9539-7

20. YENNURAJALINGAM S, PALMER JL, CHACKO R, BRUERA E. Factors associated with response to methylphenidate in advanced cancer patients. Oncologist 2011; 16: 246-253.

https://doi.org/10.1634/theoncologist.2010-0214

21. JOHNSON RL, BLOCK I, GOLD MA, MARKWELL S, ZUPANCIC M. Effect of methylphenidate on fatigue in women with recurrent gynecologic cancer. Psychooncology 2010; 19: 955-958.

https://doi.org/10.1002/pon.1646

22. KERR CW, DRAKE J, MILCH RA, BRAZEAU DA, SKRETNY JA, BRAZEAU GA et al. Effects of methylphenidate on fatigue and depression: a randomized, double-blind, placebo-controlled trial. J Pain Symptom Manage 2012; 43: 68-77.

https://doi.org/10.1016/j.jpainsymman.2011.03.026

23. PORTELA MA, SANZ A, MARTÍNEZ M, CENTENO C. Astenia en cáncer avanzado y uso de psicoestimulantes. An Sist Sanit Navar 2011; 34: 471-479.

https://doi.org/10.4321/S1137-66272011000300013

Descargas

Publicado

06-09-2013

Cómo citar

1.
Saralegui A, Palacio P, Royo P. Revisión sobre el uso del metilfenidato para el tratamiento de la astenia en pacientes paliativos. An Sist Sanit Navar [Internet]. 6 de septiembre de 2013 [citado 6 de diciembre de 2025];36(2):287-93. Disponible en: https://recyt.fecyt.es/index.php/ASSN/article/view/24008532

Número

Sección

Revisiones

Artículos similares

<< < 1 2 3 4 5 6 7 8 9 10 > >> 

También puede Iniciar una búsqueda de similitud avanzada para este artículo.