Modulation of biomarkers expression (OR, PR and C-erbB2) in breast cancer following neoadjuvant treatment
Keywords:
Receptores de estrógeno. Receptores de progesterona. C-erbB2. Neoadyuvancia.Abstract
Introduction. Pre and post-operative oncological therapy in patients with breast cancer is determined, amongst other factors, by hormone receptor status and by c-erbB2 expression. The aim of this study is to determine the influence of neoadjuvant therapy on the expression of oestrogen receptor (OR), progesterone receptor (PR) and c-erbB2. Methods. Fifty-three patients with breast cancer diagnosed by tru-cut biopsy were studied. Patients with locally advanced carcinoma (20) had preoperative treatment. All patients underwent surgical resection. Expression of OR, PR and c-erbB2 in both the tru-cut biopsy and the gross specimen was compared. Results: We found significant differences in OR, PR expression in both biopsy and gross specimen, between the group of patients who underwent neoadjuvant treatment and the group without pre-surgical treatment. Changes in PR, OR and c-erbB2 status were found between the tru-cut biopsy and the gross specimen, in about 10 to 40% of the cases who received neoadjuvant therapy. These changes had no statistical significance.Downloads
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Published
2008-11-03
How to Cite
Córdoba Iturriagagoitia, A., Ederra, M., Arrechea, M., De Llano, P., & Martínez-Peñuela, J. (2008). Modulation of biomarkers expression (OR, PR and C-erbB2) in breast cancer following neoadjuvant treatment. Anales Del Sistema Sanitario De Navarra, 29(3), 349–356. Retrieved from https://recyt.fecyt.es/index.php/ASSN/article/view/2548
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Research articles
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