Autologous hematopoietic stem cell transplantation in a patient with refractory Crohn's disease

Authors

  • Ana Gordo Ortega Servicio Navarro de Salud-Osasunbidea. Hospital Universitario de Navarra. Servicio de Aparato Digestivo. Pamplona. España. https://orcid.org/0009-0000-9836-941X
  • Maren Eizaguirre Ubegun Servicio Navarro de Salud-Osasunbidea. Hospital Universitario de Navarra. Servicio de Aparato Digestivo. Pamplona. España. https://orcid.org/0009-0009-0714-5994
  • Martín Balerdi Trébol Servicio Navarro de Salud-Osasunbidea. Hospital Universitario de Navarra. Servicio de Aparato Digestivo. Pamplona. España. https://orcid.org/0009-0007-2096-8886
  • Saioa Rubio Iturria Servicio Navarro de Salud-Osasunbidea. Hospital Universitario de Navarra. Servicio de Aparato Digestivo. Pamplona. España. https://orcid.org/0000-0002-3489-3623
  • Cristina Rodríguez Gutiérrez Servicio Navarro de Salud-Osasunbidea. Hospital Universitario de Navarra. Servicio de Aparato Digestivo. Pamplona. España.

DOI:

https://doi.org/10.23938/ASSN.1054

Keywords:

Crohn disease, Transplantation, autologous, Hematopoietic stem cell, Bone marrow

Abstract

Crohn's disease is a chronic condition for which sometimes there is no effective medical or surgical treatment. Autologous hematopoietic stem cell transplantation may be a therapeutic option for these patients to restore immune tolerance. Consequently, this may lead to remission of the disease or decrease its activity, making drugs that have previously failed be effective. Due to the safety profile of the procedure and the fact that it is a non-curative treatment, patient selection must be rigorous.

We report our experience with the first patient selected in our centre for autologous hematopoietic stem cell transplantation: 27 years old male with Crohn's disease (A1L3B1p) refractory to multiple lines of medical treatment and not a candidate for surgical treatment. Two years after the transplantation, the patient remains asymptomatic.

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References

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Published

2023-11-15

How to Cite

Gordo Ortega, A., Eizaguirre Ubegun, M., Balerdi Trébol, M., Rubio Iturria, S., & Rodríguez Gutiérrez, C. (2023). Autologous hematopoietic stem cell transplantation in a patient with refractory Crohn’s disease. Anales Del Sistema Sanitario De Navarra, 46(3), e1054. https://doi.org/10.23938/ASSN.1054

Issue

Vol. 46 No. 3 (2023): September - December 2023

Section

Clinical notes

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