Mecanismos patogénicos de infección por SARS-CoV-2 y enfermedad renal: una perspectiva clínico-molecular

Una Perspectiva Clínico-Molecular

Autores/as

  • W. Torres Centro de Investigaciones Endocrino-Metabólicas “Dr. Félix Gómez”. Escuela de Medicina. Universidad del Zulia. Maracaibo https://orcid.org/0000-0002-7068-0190
  • V. Morillo Centro de Investigaciones Endocrino-Metabólicas “Dr. Félix Gómez”. Escuela de Medicina. Universidad del Zulia. Maracaibo https://orcid.org/0000-0001-7190-9586
  • A. Manzano Centro de Investigaciones Endocrino-Metabólicas “Dr. Félix Gómez”. Escuela de Medicina. Universidad del Zulia. Maracaibo. https://orcid.org/0000-0001-6652-8834
  • M.K. Suarez Centro de Investigaciones Endocrino-Metabólicas “Dr. Félix Gómez”. Escuela de Medicina. Universidad del Zulia. Maracaibo. https://orcid.org/0000-0003-0478-8950
  • H. Parra Centro de Investigaciones Endocrino-Metabólicas “Dr. Félix Gómez”. Escuela de Medicina. Universidad del Zulia. Maracaibo. https://orcid.org/0000-0002-6604-4212
  • V. Lameda Centro de Investigaciones Endocrino-Metabólicas “Dr. Félix Gómez”. Escuela de Medicina. Universidad del Zulia. Maracaibo. https://orcid.org/0000-0003-4769-1497
  • M. Nava Centro de Investigaciones Endocrino-Metabólicas “Dr. Félix Gómez”. Escuela de Medicina. Universidad del Zulia. Maracaibo. https://orcid.org/0000-0001-9769-1693
  • L. D’Marco Departamento de Nefrología. Hospital Clínico Universitario. INCLIVA. Valencia. https://orcid.org/0000-0003-0148-891X
  • M.J. Puchades Departamento de Nefrología. Hospital Clínico Universitario. INCLIVA. Valencia.
  • O. Medina Facultad de Ciencias Sociales y Jurídicas. Universidad Simón Bolívar. Cúcuta. https://orcid.org/0000-0002-2472-1238
  • X.E. Guerra-Torres Sección de Nefrología. Hospital Universitario Príncipe de Asturias. Alcalá de Henares. Madrid. https://orcid.org/0000-0001-5999-225X
  • V. Bermúdez Facultad de Ciencias de la Salud. Universidad Simón Bolívar. Barranquilla. http://orcid.org/0000-0003-1880-8887

DOI:

https://doi.org/10.23938/ASSN.0973

Palabras clave:

SARS-CoV-2, COVID-19, enzima convertidora de angiotensina 2, enfermedad renal crónica, lesión renal aguda

Resumen

La infección por SARS-CoV-2 se ha convertido en un problema mundial de salud pública. Su presentación clínica es variada, desde benigna hasta un síndrome de distrés respiratorio agudo, afectación sistémica y fallo multiorgánico. La severidad del cuadro clínico depende de factores biológicos del virus y del huésped y de comorbilidades como la enfermedad renal. Además, la interacción entre el virus, la enzima convertidora de angiotensina 2 y la respuesta inmunológica exacerbada podría conducir al desarrollo de lesión renal aguda. Sin embargo, las implicaciones de la infección por SARS-CoV-2 sobre las células renales, las repercusiones pronósticas en los pacientes con enfermedad renal crónica y su efecto a largo plazo sobre la función renal no están del todo claras. El objetivo es revisar el papel del SARS-CoV-2 en la enfermedad renal aguda y crónica, y sus posibles mecanismos patogénicos en la afectación renal.

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Publicado

2021-12-27

Cómo citar

Torres, W., Morillo, V., Manzano, A., Suarez, M., Parra, H., Lameda, V., Nava, M., D’Marco, L., Puchades, M., Medina, O., Guerra-Torres, X., & Bermúdez, V. (2021). Mecanismos patogénicos de infección por SARS-CoV-2 y enfermedad renal: una perspectiva clínico-molecular: Una Perspectiva Clínico-Molecular. Anales Del Sistema Sanitario De Navarra, 44(3), 445–456. https://doi.org/10.23938/ASSN.0973