Predictive value of hyperglycosylated human chorionic gonadotropin for pregnancy outcomes in threatened abortion in first-trimester viable pregnancies

Authors

  • A. Salas Departamento de Obstetricia y Ginecología. Clínica Universidad de Navarra. Pamplona. España
  • B. Gastón Departamento de Obstetricia y Ginecología. Complejo Hospitalario de Navarra. Pamplona. España.
  • J. Barrenetxea Departamento de Obstetricia y Ginecología. Complejo Hospitalario de Navarra. Pamplona. España.
  • T. Sendino Laboratorio de Bioquímica. Clínica Universidad de Navarra. Pamplona. España.
  • M. Jurado Departamento de Obstetricia y Ginecología. Clínica Universidad de Navarra. Pamplona. España
  • J.L. Alcázar Departamento de Obstetricia y Ginecología. Clínica Universidad de Navarra. Pamplona. España

DOI:

https://doi.org/10.23938/ASSN.0933

Keywords:

hCG, Early pregnancy, First trimester bleeding, Threatened abortion, Miscarriage

Abstract

Background. To investigate the value of a single determination of hyperglycosylated hCG (hCG-H) for predicting the clinical outcome of patients with threatened abortion in the first trimester of pregnancy.

Methods. Prospective study performed on 86 consecutively selected women with a diagnosis of threatened abortion and viable intrauterine pregnancy in the first trimester of pregnancy, conducted in two tertiary care hospitals. All patients underwent a single blood sample to determine hCG-H and total hCG serum levels and a transvaginal ultrasound 12-24 hours after diagnosis. Patients were monitored to determine whether the outcome was a miscarriage before the 20th week of pregnancy.

Results. Forty-three women (50%) had a miscarriage during the follow-up. We observed a very high correlation between hCG-H and total hCG (r = 0.91, p < 0.001). Median hCG-H and total hCG from pregnancies with normal outcome was significantly higher than those ending in abortion. hCG-H and total hCG were very similar predictors of pregnancy outcomes (AUC: 0.90 and 0.89, respectively). The ratio hCG-H / total hCG was a poor predictor (AUC: 0.64).

Conclusion. A single hCG-H assay is helpful for predicting pregnancy outcomes in women with first trimester threatened abortion and viable or potentially viable pregnancy at the time of presentation. However, hCG-H is not a better predictor than total hCG.

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Published

2021-04-28

How to Cite

Salas, A., Gastón, B., Barrenetxea, J., Sendino, T., Jurado, M., & Alcázar, J. (2021). Predictive value of hyperglycosylated human chorionic gonadotropin for pregnancy outcomes in threatened abortion in first-trimester viable pregnancies. Anales Del Sistema Sanitario De Navarra, 44(1), 23–31. https://doi.org/10.23938/ASSN.0933

Issue

Vol. 44 No. 1 (2021): January - April 2021

Section

Research articles

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