Effect of antidiabetes treatment adjustment at discharge on 30-day outcomes of patients with diabetes mellitus presenting to an emergency department with hypoglycemia

Authors

  • R. Cuervo Pinto Hospital Clínico San Carlos de Madrid http://orcid.org/0000-0002-3522-486X
  • E. Rodríguez Adrada Hospital Clínico San Carlos
  • C. Domínguez Bernal Hospital Clínico San Carlos
  • D. Chaparro Pardo Hospital Clínico San Carlos
  • F. J. Martín Sánchez Hospital Clínico San Carlos
  • J. M. González del Castillo Hospital Clínico San Carlos

DOI:

https://doi.org/10.23938/S1137-6627/2016000100011

Keywords:

Hipoglucemia, Diabetes Mellitus, Antidiabéticos, Insulina, Urgencias

Abstract

Background. To determine if antidiabetes treatment adjustment at discharge from an Emergency Department (ED) is associated with 30-day outcomes in patients with diabetes mellitus presenting to the ED with hypoglycemia.

Methods. Retrospective cohort observational study. Patients with diabetes mellitus presenting to the ED with hypoglycemia directly discharged from the ED between 2012-2014 were included. Primary outcome was a 30-day composite adverse event (mortality or revisiting).

Results. A total of 203 patients were included with a mean age of 69.7 (SD18.9), mainly type 2 diabetics. Hypoglycemia was the primary diagnosis in 162 (79%) of patients and antidiabetes treatment was adjusted at discharge in 98 (48%) of cases. Non-adjustment of antidiabetes treatment at ED discharge was an independent factor associated with a 30-day adverse event (OR=2.8; CI 95%=1.34-5.93; p=0.006).

Conclusions. Non-adjustment of antidiabetes treatment at discharge in patients with diabetes mellitus presenting to the ED with hypoglycemia could be an independent factor of suffering a 30-day adverse event.

Keywords. Hypoglycemia. Emergency department. Diabetes mellitus. Antidiabetes treatment. Insulin.

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Author Biographies

R. Cuervo Pinto, Hospital Clínico San Carlos de Madrid

Medico especialista en Medicina Interna

Servicio de Urgencias. Hospital Clínico San Carlos de Madrid.

E. Rodríguez Adrada, Hospital Clínico San Carlos

.

C. Domínguez Bernal, Hospital Clínico San Carlos

.

D. Chaparro Pardo, Hospital Clínico San Carlos

.

F. J. Martín Sánchez, Hospital Clínico San Carlos

.

J. M. González del Castillo, Hospital Clínico San Carlos

.

References

. BANARER S, CRYER PE. Hypoglycemia in type 2 diabetes. Med Clin North Am 2004; 88: 1107-1116.

https://doi.org/10.1016/j.mcna.2004.04.003

2. LEESE GP, WANG J, BROOMHALL J, KELLY P, MARSDEN A, MORRISON W et al. Frequency of severe hypoglycemia requiring emergency treatment in type 1 and 2 diabetes. Diabetes Care 2003; 26: 1176-1180.

https://doi.org/10.2337/diacare.26.4.1176

3. MOISAN J, BRETON MC, VILLENEUVE J, GRÉGOIRE JP. Hypoglycemia -related emergency department visits an hypoglycemia-related hospitalization among new users of antidiabetic treatments. Can J Diabetes 2013; 37: 143-149.

https://doi.org/10.1016/j.jcjd.2013.02.039

4. KIM Y, RAJAN KB, SIMS SA, WROBLEWSKI KE, REUTRAKUL S. Impact of glycemic variability and hypoglycemia on adverse hospital outcomes in non-critically ill patients. Diab Res Clin Pract 2014; 103: 437-443.

https://doi.org/10.1016/j.diabres.2013.11.026

5. ROWE BH, SINGH M, VILLA-ROEL C, LEITER LA, HRAMIAK I, EDMONDS ML et al. Acute management and outcomes of patients with diabetes mellitus presenting to Canadian emergency departments with hypoglycemia. Can J Diabetes 2015; 39: 55-64.

https://doi.org/10.1016/j.jcjd.2014.04.001

6. RAJEDRAN R, HODGKINSON D, RAYMAN G. Patients with diabetes requiring emergency department care for hypoglycaemia: characteristics and long-term outcomes determined from multiple data sources. Postgrad Med 2015; 91: 65-71.

https://doi.org/10.1136/postgradmedj-2014-132926

7. AGUDO VILLA T, ÁLVAREZ-RODRÍGUEZ E, CAUREL SASTRE Z, MARTÍN MARTÍNEZ A, MERINERO PALOMARES R, ÁLVAREZ RODRÍGUEZ V et al. Prevención de las complicaciones cardiovasculares asociadas a la diabetes mellitus en los servicios de urgencias. Emergencias 2015; 27: 150-154.

8. NAVARRO-DÍAZ FJ, AMILLO M, ROSALES M, PANADERO A, ENA J. Oportunidades de mejora en la asistencia a los pacientes con cetoacidosis diabética atendidos en los servicios de urgencias. Emergencias 2015; 27: 39-42.

9. ZAMMIT NN, FRIER BM. Hypoglycemia in type 2 Diabetes. Pathophysiology, frequency, and effects of different treatment modalities. Diabetes Care 2005; 28: 2948-2961.

https://doi.org/10.2337/diacare.28.12.2948

10. CLEMENT S, BRAITHWAITE SS, MAGEE MF, AHMANN A, SMITH EP, SCHAFER RG et al. Management of diabetes and hyperglycemia in hospitals. Diab Care 2004; 27: 553-591.

https://doi.org/10.2337/diacare.27.2.553

11. ZOUNGAS S, PATEL A, CHALMERS J, DE GALAN BE, LI Q, BILLOT L et al. Severe hypoglycemia and risks of vascular events and death. N Engl J Med 2010; 363: 1410-1418.

https://doi.org/10.1056/NEJMoa1003795

Published

2016-04-29

How to Cite

1.
Cuervo Pinto R, Rodríguez Adrada E, Domínguez Bernal C, Chaparro Pardo D, Martín Sánchez FJ, González del Castillo JM. Effect of antidiabetes treatment adjustment at discharge on 30-day outcomes of patients with diabetes mellitus presenting to an emergency department with hypoglycemia. An Sist Sanit Navar [Internet]. 2016 Apr. 29 [cited 2025 Dec. 5];39(1):99-104. Available from: https://recyt.fecyt.es/index.php/ASSN/article/view/39595

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Short articles

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