Inmunogenic Action of the Vaccine Against the Hepatitis B Virus in School Children in Madrid

Abstract

We carried out a vaccine program against Hepatitis B in scholar population aged 5 to 17 educated in 3 institutions of Madrid cyti/ region. Those cildren who followed the vaccination criteria (negative HBsAg and Anti HBc markers) were vaccinated. The vaccination regimen (Engerix B recombinant DNA vaccine) was O-l-6 months and dose was 10 and 20 ug i.m. for those aged 6 to 13 and 13 to 17 respectively. The postvaccine serologic results (anti-HBs titer) was evaluated one month after tha last dose, at 7th month fron the beginning. The variables of study were age and sex for each individual. Corresponding to these variables both seroconversion rate (percentaje of patiens- with 10 Ul/l ofanti-HBs) and thegeometric mean titer of antibodis (GMT anti-HBs titer) were determinated. The overall seroconversion rate at 7th month was 99 %. Tbere is not significant association neither regarding the sex nor mean age betwenn ?responder? and ?no responders?. The titer of anti-HBs antibodies, expresed using the G.M.T., which was reached at 7th month was 9.283,2 UI/I. Finally, there is not correlation between age and anti- HBs antibody titer.