PRECLINICAL TESTING OF THE DOUBLE IRON OXIDE-BASED HEALTH SUPPLEMENT

Resumen

The development and use of food and dietary nano-supplements in food technologies with a wide range of functional and technological properties is a promising scientific and practical direction of modern healthy nutrition.
The double iron oxide-based health supplement Fe3O4 has the form of ultrathin powder with a particle size of (70–80) nm. For the use of this health supplement in the field of healthy nutrition, nutrition during recovery and sports nutrition a testing was conducted. This article presents the results of the testing of the safety data of a new health supplement in preclinical laboratory animal studies and in vitro.
The results of the cytotoxic testing indicate that the health supplement exhibits a cytotoxic effect only at concentrations (20 mg / ml; 10 mg / ml; 5 mg / ml). At concentrations equivalent to the daily human intake of the product, no toxic effect on the red bone marrow cell culture of rats was revealed, as evidenced by the absence of a statistically significant decrease in the number of viable bone marrow cells. In addition, at concentrations of 0.00002 mg / ml at 90 minutes of incubation, the health supplement produced a cytoprotective effect, statistically significantly increasing the viability of rat bone marrow cells.
Thus, the testing conducted proves that the double iron oxide-based health supplement is sufficiently safe, which entails the prospect for its widespread use in healthy food production technologies and allows recommending the health supplement for further studies with regard to its safety parameters.