Niveles de Vascular Endothelial Growth Factor: ejercicio moderado versus baja intensidad con restricción flujo

Autores/as

  • Nanda Aulya Ramadhan Faculty of Medicine / Universitas Airlangga Hospital, Universitas Airlangga https://orcid.org/0000-0001-6968-1455
  • Damayanti Tinduh Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
  • Nuniek Nugraheni Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
  • Imam Subadi Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
  • Inggar Narasinta Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia https://orcid.org/0009-0007-6855-413X
  • Soenarnatalina Melaniani Department of Epidemiology, Biostatistics, Population Studies, and Health Promotion, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia

DOI:

https://doi.org/10.47197/retos.v64.110307

Palabras clave:

Mujeres mayores, VEGF, BFR, ejercicio de fortalecimiento, masa muscular

Resumen

Introducción y Objetivo: Los cambios moleculares afectan la regeneración y degeneración de las proteínas musculares, lo que causa la reducción de la masa muscular en los individuos mayores. El Factor de Crecimiento Endotelial Vascular promueve la angiogénesis y aumenta la masa muscular al mejorar las células satélite. Las personas mayores a menudo tenían preocupaciones sobre la seguridad y la tolerancia al realizar ejercicios de fortalecimiento de alta intensidad debido a limitaciones. Los ejercicios de baja intensidad con restricción del flujo sanguíneo son una alternativa viable para mejorar la fuerza muscular, con resultados similares a los de alta intensidad. Se efectuó una comparación de los niveles de factor de crecimiento endotelial vascular en mujeres de edad avanzada que ejecutaron ejercicios de fortalecimiento de intensidad media y baja, con restricción del flujo de sangre.

Metodología: Veintidós participantes participaron en un programa de entrenamiento de seis semanas, y se realizaron evaluaciones al inicio, inmediatamente después del ejercicio y al término del período de entrenamiento. Un grupo realizó ejercicios de fortalecimiento de intensidad moderada y otro grupo realizó ejercicios de baja intensidad con restricción del flujo sanguíneo.

Resultados y Conclusiones: A pesar de los incrementos notables en los niveles de factor de crecimiento endotelial vascular, el grupo de baja intensidad no registró efectos crónicos. Las actividades de fortalecimiento de intensidad reducida con restricción del flujo sanguíneo pueden fomentar un incremento inmediato en los niveles de factor de crecimiento endotelial vascular en mujeres de edad avanzada.

Citas

Amalia, F., Sari, GM, Lukitasari L., Othman, Z., Herawati, L., Riyono, A. 2024. Moderate intensity continuous and interval training increased VEGF and decreased cholesterol levels in female rats high calorie diet. Retos, 59, 130-137

Egner IM, Bruusgaard JC, and Gundersen K. 2016. Satellite cell depletion prevents fiber hypertrophy in skeletal muscle. Development 143(16): 2898-906. doi: 10.1242/dev.134411. PubMed PMID: 27531949.

Farhan Nurdiansyah, Rwahita Satyawati Dharmanta, Hadiq Firdausi, & Nuniek Nugraheni Sulistiawati. (2024). Profile of Sarcopenia in Elderly Patients at The Medical Rehabilitation Outpatient Department Dr. Soetomo General Academic Hospital. Surabaya Physical Medicine and Rehabilitation Journal, 6(2), 148–158. https://doi.org/10.20473/spmrj.v6i2.55119

Ferrara, N., Komici, K., Corbi, G., Pagano, G., Furgi, G., and Rengo, C., et al. 2014. β-adrenergic receptor responsiveness in aging heart and clinical implications. Front Physiol 4: 396. doi: 10.3389/fphys.2013.00396

Freitas, E. D., Karabulut, M., and Bemben, M. G. 2021. The Evolution of Blood Flow Restricted Exercise. Frontiers in Physiology 12:747759. doi: 10.3389/fphys.2021.747759

Fry CS, Lee JD, Jackson JR, Kirby TJ, Stasko SA, and Liu H, et al. 2014. Regulation of the muscle fiber microenvironment by activated satellite cells during hypertrophy. FASEB J;28(4):1654-65. doi: 10.1096/fj.13-239426.

Fujimaki S, Machida M, Wakabayashi T, Asashima M, Takemasa T, and Kuwabara T. 2016. Functional Overload Enhances Satellite Cell Properties in Skeletal Muscle. Stem Cells Int. doi: 10.1155/2016/7619418.

Gavin TP, Drew JL, Kubik CJ, Pofahl WE, and Hickner RC. 2007. Acute resistance exercise increases skeletal muscle angiogenic growth factor expression. Acta physiol. 191(2):139-46. doi: 10.1111/j.1748-1716.2007.01723.x.

Huey K. A. 2018. Potential Roles of Vascular Endothelial Growth Factor During Skeletal Muscle Hypertrophy. Exerc Sport Sci Rev., 46(3), 195–202. https://doi.org/10.1249/JES.0000000000000152

Kristiana, T., Widajanti, N., & Satyawati, R. (2020). Association between Muscle Mass and Muscle Strength with Physical Performance in Elderly in Surabaya. Surabaya Physical Medicine and Rehabilitation Journal, 2(1), 24–34. https://doi.org/10.20473/spmrj.v2i1.16313

Laswati H, Sugiarto D, Poerwandari D, Pangkahila JA, Kimura H. Low-Intensity Exercise with Blood Flow Restriction Increases Muscle Strength without Altering hsCRP and Fibrinogen Levels in Healthy Subjects. Chin J Physiol. 2018 Jun;61(3):188-195. doi: 10.4077/CJP.2018.BAG567. PMID: 29962179.

Lee, D. C., Sui, X., Artero, E. G., Lee, I. M., Church, T. S., and McAuley, P. A., et al., 2011. Long-term effects of changes in cardiorespiratory fitness and body mass index on all-cause and cardiovascular disease mortality in men: the Aerobics Center Longitudinal Study. Circ. 124(23): p. 2483-90. doi: 10.1161/ circulationaha.111.038422

Li Shuoqi, Li Shiming, Wang Lifeng, Quan Helong, Yu Wenbing, and Li Ting, et al. 2022. The Effect of Blood Flow Restriction Exercise on Angiogenesis-Related Factors in Skeletal Muscle Among Healthy Adults: A Systematic Review and Meta-Analysis. Front. Physiol. 13, 814965. https://doi.org/10.3389/fphys.2022.814965

Maga, M., Schönborn, M., Wachsmann-Maga, A., ´Sliwka, A., Kre˛z˙ el, J., and Włodarczyk, A, et al. 2022. Stimulation of the Vascular Endothelium and Angiogenesis by Blood-Flow-Restricted Exercise. Int. J. Environ. Res. Public Health, 19, 15859. https://doi.org/10.3390/ijerph192315859

McCarthy JJ, Mula J, Miyazaki M, Erfani R, Garrison K, and Farooqui AB, et al. 2011. Effective fiber hypertrophy in satellite cell-depleted skeletal muscle. Development ;138(17):3657-66. doi: 10.1242/dev.068858.

Nascimento, W., Ferrari, G., Martins, C.B., Rey-Lopez JP, Izquierdo M., and Lee DH, et al. 2021. Muscle-strengthening activities and cancer incidence and mortality: a systematic review and meta-analysis of observational studies. Int J Behav Nutr Phys Act. 18(1): 69. doi: 10.1186/s12966-021-01142-7

Rudrappa SS, Wilkinson DJ, Greenhaff PL, Smith K, Idris I, and Atherton PJ. 2016. Human skeletal muscle disuse atrophy: Effects on muscle protein synthesis, breakdown, and insulin resistance: A qualitative review. Front Physiol 7: 1-10

Seynnes OR, Erskine RM, Maganaris CN, Longo S, Simoneau EM, Grosset JF, Narici MV. 2009. Training-induced changes in structural and mechanical properties of the patellar tendon are related to muscle hyper-trophy but not to strength gains. J Appl Physiol 107: 523–530. First published May 28, 2009; doi:10.1152/japplphysiol.00213.2009

Summer BC, Dain PL, Michelle RV, Hannah B, and Todd MM. 2017. Blood flow restricted resistance training in older adults at risk of mobility limitations. Exp. Gerontol 99 (2017) 138–145. http://dx.doi.org/10.1016/j.exger.2017.10.004

Valenzuela, PL., Castillo-García, A., Morales, JS., Izquierdo, M., Serra-Rexach, JA., and Santos-Lozano, A. et al. 2019. Physical Exercise in the Oldest Old. American Physiological Society Compr Physiol 9:1281-1304. DOI:10.1002/cphy.c190002

WHO. 2024. Ageing with Dignity: The Importance of Strengthening Care and Support Systems for Older Persons Worldwide. https://www.un.org/en/observances/older-persons-day Accessed 26th September 2024

Ye, G., Xiao, Z., Luo, Z., Huang, X., Abdelrahim, E. A., and Huang, W. 2020. Resistance training effect on serum insulin-like growth factor 1 in the serum: a meta-analysis. The Aging Male, 1–9. doi:10.1080/13685538.2020.1801622.

Yeung, S. S. Y., Reijnierse, E. M., Deen, P. J. J. F., Trappenburg, M. C., Meskers, C. G. M., and Maier, A. B. 2021. Nutrient Intake and Muscle Measures in Geriatric Outpatients. J Am Coll Nutr., 40(7), 589–597. https://doi.org/10.1080/07315724.2020.1800533

Yuki A, Ando F, Otsuka R, and Shimokata H. 2015. Low free testosterone is associated with loss of appendicular muscle mass in Japanese community dwelling women. Geriatr Gerontol Int 15: 326-333.

Zhao Y, Lin A, and Jiaoc L. 2020. Eight weeks of resistance training with blood flow restriction improve cardiac function and vascular endothelial function in healthy young Asian males. Int. Health; 13: 471–479. doi:10.1093/inthealth/ihaa089

Mujica-Johnson, F. N., Concha López, R., Peralta Ferroni, M., & Burgos Henríquez, S. (2024). Gender Perspective in Physical Education Teacher and School Training. Critical analysis in terms of the Chilean context (Gender perspective in Physical Education, teacher training and schooling. Critical analysis based on the chilean context). Challenges, 55, 339–345. https://doi.org/10.47197/retos.v55.103535

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Publicado

2025-03-01

Cómo citar

Ramadhan, N. A., Tinduh, D., Nugraheni, N., Subadi, I., Narasinta, I., & Melaniani, S. (2025). Niveles de Vascular Endothelial Growth Factor: ejercicio moderado versus baja intensidad con restricción flujo. Retos, 64, 254–262. https://doi.org/10.47197/retos.v64.110307

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Artículos de carácter científico: investigaciones básicas y/o aplicadas